Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women

Abstract

Background: An increase in serum undercarboxylated osteocalcin concentrations suggests vitamin K deficiency. Clinical intervention studies suggested that the vitamin K supplementation might contribute to preventing bone loss in postmenopausal women. Evidence on the relationship between serum undercarboxylated osteocalcin (ucOC) levels and bone parameters of quantitative ultrasound (QUS) is limited. We examined the correlation between serum ucOC concentrations and bone status as measured by QUS among middle-aged and older Japanese men and women. Methods: The subjects were community-dwelling men (n = 358) and women (n = 503) aged ≥ 40 years in Japan. Heel QUS parameters, including the stiffness index, speed of sound, and broadband ultrasound attenuation, were measured. Serum ucOC concentrations were measured by electrochemiluminescence immunoassay. Grip strength was measured in the dominant hand. Information on alcohol drinking, current smoking, exercise, and menopause in women was collected. Results: Serum ucOC concentrations were significantly associated with age in both sexes. Serum ucOC concentrations in men were higher at ≥ 80 years than those in the age groups of 40-49, 50-59, and 60-69 years. Serum ucOC concentrations in women were higher in the age groups of 50-59 and 60-69 years than those at 40-49 years. Partial correlation analysis adjusting for covariates (age, body mass index, grip strength, alcohol drinking, current smoking, and exercise in men; age, body mass index, grip strength, alcohol drinking, current smoking, exercise, and menopause in women) showed that serum ucOC concentrations were negatively significantly correlated with all QUS parameters in women. Serum ucOC concentrations were not correlated with them in men. Conclusions: Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women.

Association between fat mass by bioelectrical impedance analysis and bone mass by quantitative ultrasound in relation to grip strength and serum 25-hydroxyvitamin D in postmenopausal Japanese women: the Unzen study

“…We applied Pearson's product-moment correlations to assess for correlation among SI, fat mass, muscle mass, log (25(OH)D), log (TRACP-5b), log (PTH), and grip strength. Multiple linear regression analysis was used to explore the effects of fat mass and muscle mass on SI, with adjustment for age, height, comorbidity, current smoking, alcohol consumption, and exercise (Model 1) [11,28,29]. We added log (25(OH)D), log (TRACP-5b), log (PTH), and grip strength to model 1 (model 2) [30][31][32].…”

Undercarboxylated Osteocalcin and Its Associations With Bone Mineral Density, Bone Turnover Markers, and Prevalence of Osteopenia and Osteoporosis in Chinese Population: A Cross-Sectional Study

“…Natsumi et al. ( 21 ) revealed that vitamin K deficiency and high serum ucOC were correlated with poor bone status in women. Furthermore, some studies have demonstrated that higher serum ucOC levels were associated with lower BMD in women ( 22 – 24 ).…”

“…Vergnaud et al (20) found that serum ucOC predicted the risk of hip fracture independent of femoral neck BMD in older women. Natsumi et al (21) revealed that vitamin K deficiency and high serum ucOC were correlated with poor bone status in women. Furthermore, some studies have demonstrated that higher serum ucOC levels were associated with lower BMD in women (22)(23)(24).…”

Direct‑acting antiviral treatment decreases serum undercarboxylated osteocalcin in male patients with chronic hepatitis C

“…Cholestasis induces VK deficiency and osteoporosis (19). Consequently, VK deficiency elevates the levels of undercarboxylated osteocalcin (ucOC) (20), a marker of bone metabolism. Measurements of BMD and bone metabolic markers are useful for the diagnosis and management of osteoporosis (21,22).…”