Vitamin K in Medical Practice: Adults

Deutsch, Erwin

doi:10.1016/s0083-6729(08)60229-0

Cited by 12 publications

(2 citation statements)

References 45 publications

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“…The various physiological and dietary factors which may be involved in the induction of vitamin-K deficiency have been discussed by Doisy &Matschiner (1965) andScott (1966). The use of vitamin K in the treatment of different deficiency states has been reviewed in relation to newborn infants by Vest (1966) and in adults by Deutsch (1966). Little is known about the precise way in which vitamin K is concerned with the material was mixed with 0.5 ml Konakion containing I mg vitamin Ki as carrier, dispersed in about 100 ml milk, and swallowed half-way through a small meal consisting oftwo buttered rolls with cheese.…”

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confidence: 99%

Absorption and Excretion of an Oral Dose of Tritiated Vitamin K₁ in Man

1970

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The radioactivity in the plasma, urine and faeces has been determined in three studies carried out in two normal men after an oral dose of tritiated vitamin K, (50-100 pCi). Radioactivity in the plasma was detected by 30 min, reached a peak at 2-4 hr and then declined relatively rapidly. A low level of radioactivity persisted in the plasma for at least 96 hr. Most of the radioactivity in the 297 298 M. J. Shearer, P. Barkhan and G. R. Webster synthesis of prothrombin and related clotting factors. It has been suggested (Van der Meer et al, 1968) that the vitamin-K dependent coagulation factors are synthesized in two steps: first, a polypeptide precursor of the factor is formed and then this precursor is changed into the functionally active form in a vitamin-K dependent step.Much remains to be known about the metabolism of vitamin K, in man and the work reported in this paper was aimed at obtaining information on the absorption of vitamin

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confidence: 99%

Absorption and Excretion of an Oral Dose of Tritiated Vitamin K₁ in Man

1970

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“…This has been used to amplify the therapeutic effectiveness of X rays (99). Another observa tion supports the view that vitamin K increases the analgesic effect of opiates and salicylates.…”

Section: Vitamin Kmentioning

confidence: 65%

Vitamin Toxicity

DiPalma¹,

Ritchie²

1977

Annu. Rev. Pharmacol. Toxicol.

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Role of Feeding and Vitamin K in Hypoprothrombinemia of the Newborn

Keenan¹,

Jewett²,

Glueck³

1971

Arch Pediatr Adolesc Med

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Whole blood prothrombin times were determined serially in five groups of randomly selected well newborn "term" infants, none of whom had clinical evidence of bleeding. Prothrombin values in infants given menadione sodium bisulfite (vitamin K) parenterally shortly after birth were stable. The remainder of the infants who were not given vitamin K were divided into subgroups. Twenty-four hours after the first feeding, prothrombin activity of infants fed cow's milk did not differ significantly from that of infants given vitamin K at birth. In contrast, prothrombin times 24 hours after the first feeding of breast fed infants, of infants given bottled human milk, or of infants receiving only sterile water, were all significantly longer than that of infants given vitamin K parenterally. The responses of these newly born infants to the various feeding regimens appear to represent an in vivo assay for dietary vitamin K. The data document hypoprothrombinemia in the majority of infants who do not receive vitamin K parenterally and emphasize the importance of the administration of a small prophylactic dose of the vitamin to all newly born infants.

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Vitamin K in Medical Practice: Adults

Cited by 12 publications

References 45 publications

Absorption and Excretion of an Oral Dose of Tritiated Vitamin K₁ in Man

Absorption and Excretion of an Oral Dose of Tritiated Vitamin K₁ in Man

Vitamin Toxicity

Role of Feeding and Vitamin K in Hypoprothrombinemia of the Newborn

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Vitamin K in Medical Practice: Adults

Cited by 12 publications

References 45 publications

Absorption and Excretion of an Oral Dose of Tritiated Vitamin K1 in Man

Absorption and Excretion of an Oral Dose of Tritiated Vitamin K1 in Man

Vitamin Toxicity

Role of Feeding and Vitamin K in Hypoprothrombinemia of the Newborn

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Absorption and Excretion of an Oral Dose of Tritiated Vitamin K₁ in Man

Absorption and Excretion of an Oral Dose of Tritiated Vitamin K₁ in Man