1990
DOI: 10.1159/000216099
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Vitamin K<sub>1</sub> Levels and Coagulation Factors in Healthy Term Newborns till 4 Weeks after Birth

Abstract: Vitamin K1 serum levels were assessed by means of an off-line multidimensional liquid chromatography in 18 mothers, shortly after delivery, and in their healthy term infants. Umbilical cord and venous blood samples were assayed up to 4 weeks of life. Concurrently, levels of coagulation factors II and X, antithrombin III and platelets were established. Although the detection limit of the assay was as low as 22 pg/ml, vitamin K1 concentration appeared to be still beyond that level in cord b… Show more

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Cited by 20 publications
(23 citation statements)
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“…Newborn infants have low plasma concentrations of vitamin K and are at risk of haemorrhagic disease if not given supplemental vitamin K 1. n 1992 an association between intramuscular vitamin K and childhood cancer was reported 2.…”
mentioning
confidence: 99%
“…Newborn infants have low plasma concentrations of vitamin K and are at risk of haemorrhagic disease if not given supplemental vitamin K 1. n 1992 an association between intramuscular vitamin K and childhood cancer was reported 2.…”
mentioning
confidence: 99%
“…Follow-up studies (7,9) have shown that in completely breast-fed infants, vitamin K1 plasma levels continue to decrease with increasing age. At one month of age, values reached 0.4-0.6 pg/l, irrespective of the route of administration of vitamin K at birth and approached those of infants without vitamin K prophylaxis (6,8). Cornelissen et al (9) have shown that infants given 1 mg of vitamin K1 im continue to have significantly higher values (329 pg/l) than those given the same amount orally (268 pg/l), even up to the age of three months (p=O.O3).…”
Section: Discussionmentioning
confidence: 82%
“…There are a number of studies reporting plasma vitamin K levels (3)(4)(5)(6)(7)(8)(9) in newborn infants. Results are difficult to compare because the time of sampling, dosage, time o f administration and route of administration of vitamin K vary from report to report.…”
Section: Discussionmentioning
confidence: 99%
“…These relatively low values are not due to vitamin K defi ciency as raising cord blood levels of phylloquinone to the endogenous maternal range by maternal oral supplementation does not improve coagulation in the fetus or neonate (Mandelbrot et al, 1988). Also, there is no detectable difference in coagulation between breast-fed and formula-fed infants in the fi rst month of life, despite the marked differences in serum phylloquinone concentrations (Pietersma-de Bruyn et al, 1990). The likely explanation for the low neonatal concentrations of vitamin K-dependent clotting factors is reduced synthesis of their precursor proteins.…”
Section: Defi Ciency In Infantsmentioning
confidence: 98%