Vitamin K2 Facilitating Inter-Organ Cross-Talk

Gordeladze, Jan O.; Haugen, Håvard Jostein; Johnsen, Gaute Floer; Møller, Mona

doi:10.5772/67153

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Low vitamin D levels are likely to contribute to muscle weakness and increased risk of falls in addition to increased bone fragility [61,62]. Finally, vitamin K is essential for the effective function of proteins including those involved for bone remodeling and it has been shown that in vitro vitamin K improves the proliferation and migration of primary bovine skeletal satellite cells, with potential in maintaining normal muscle function, as well as facilitating several pathways in muscle-bone crosstalk [63,64].…”

Section: Risk Factors and Pathophysiologymentioning

confidence: 99%

A pas de deux of osteoporosis and sarcopenia: osteosarcopenia

et al. 2021

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The musculoskeletal conditions osteoporosis and sarcopenia are highly prevalent in older adults. Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone, whereas sarcopenia is identified by the loss of muscle strength, function and mass. Osteoporosis represents a major health problem contributing to millions of fractures worldwide on an annual basis, whereas sarcopenia is associated with a range of adverse physical and metabolic outcomes. They both affect physical and social function, confidence and quality of life as well as contributing to high health-care costs worldwide. Osteosarcopenia is the term given when both conditions occur concomitantly and it has been suggested that interactions between these two conditions may accelerate individual disease progression as co-existence of osteoporosis and sarcopenia is associated with higher morbidity from falls, fracture, disability as well as mortality. In this review, we will outline the epidemiology, pathogenesis and clinical consequences of osteosarcopenia and discuss available management strategies.

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Section: Risk Factors and Pathophysiologymentioning

confidence: 99%

A pas de deux of osteoporosis and sarcopenia: osteosarcopenia

et al. 2021

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The Interplay of Muscle and Bone in Later Life

Laskou

Dennison

Patel

2021

Osteoporosis Treatment

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Interactions between gut microbiota and skeletal muscle

Gizard

Fernandez

Vadder

2020

Nutr Metab Insights

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The gut microbiota is now recognized as a major contributor to the host’s nutrition, metabolism, immunity, and neurological functions. Imbalanced microbiota (ie, dysbiosis) is linked to undernutrition-induced stunting, inflammatory and metabolic diseases, and cancers. Skeletal muscle also takes part in the interorgan crosstalk regulating substrate metabolism, immunity, and health. Here, we review the reciprocal influence of gut microbiota and skeletal muscle in relation to juvenile growth, performance, aging, and chronic diseases. Several routes involving the vascular system and organs such as the liver and adipose tissue connect the gut microbiota and skeletal muscle, with effects on fitness and health. Therapeutic perspectives arise from the health benefits observed with changes in gut microbiota and muscle activity, further encouraging multimodal therapeutic strategies.

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Vitamin K2 Facilitating Inter-Organ Cross-Talk

Cited by 3 publications

References 8 publications

A pas de deux of osteoporosis and sarcopenia: osteosarcopenia

A pas de deux of osteoporosis and sarcopenia: osteosarcopenia

The Interplay of Muscle and Bone in Later Life

Interactions between gut microbiota and skeletal muscle

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