Vitamin levels in Behçet's disease

Kandı, Başak; Çiçek, Demet; İlhan, Nevin

doi:10.1080/09546630601156355

Cited by 12 publications

(10 citation statements)

References 37 publications

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“…Kandi et al detected lower levels of vitamin D in BD patients in comparison with controls group. However this difference was not significant [37]. On the contrary our study unraveled a significantly higher level of vitamin D in BD patients in comparison with controls.…”

Section: Discussioncontrasting

confidence: 65%

Vitamin D deficiency in patients with Behcet’s disease

Faezi

Ansari

Paragomi

et al. 2014

J Diabetes Metab Disord

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BackgroundBehcet’s disease is an autoimmune, recurrent and multisystem disease. Vitamin D has immunomodulator role in immune system. So that vitamin D deficiency was reported in some autoimmune diseases. Behcet’s disease as a Silk Road disease is common in Iran. The aim of this study was to detect the serum level of 25(OH) vitamin D in Behcet’s patients and control group.MethodsIn this case–control study, 112 Behcet’s patients as cases group and 112 healthy individuals as controls group were enrolled. Any subject on vitamin D supplement, steroid, and immunosuppressors during the last 6 months were excluded. The serum level of 25(OH) vitamin D was measured in the two groups by ELISA method. The findings were compared via SPSS software.ResultsAbout 57% and 17% of Behcet’s patients had vitamin D deficiency and insufficiency respectively. Vitamin D deficiency was significantly more common in controls than cases group (P < 0.001). Vitamin D levels were significantly lower in controls (P < 0.001). Age and sex did not have any confounding effect on the results. There was no significant relationship between disease duration, disease activity, Pathergy test, HLA-B5, and HLA-B51 with vitamin D level in Behcet’s patients.ConclusionsVitamin D deficiency is common among Behcet’s patients. However, our results revealed vitamin D deficiency was significantly more common in healthy controls in comparison with Behcet’s cases.

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Section: Discussioncontrasting

confidence: 65%

Vitamin D deficiency in patients with Behcet’s disease

Faezi

Ansari

Paragomi

et al. 2014

J Diabetes Metab Disord

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“…[27128] Duygulu et al . reported an increase of synovial NO levels in active patients that probably reflected a nonspecific inflammatory process of the synovium and, therefore, a resultant arthralgia and arthritis as a common finding of BD.…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

2010

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Background:Some prominent features of Behçet’s disease (BD) are arterial and venous thromboses as a result of endothelial dysfunction. Hyperhomocysteinemia is responsible for vascular endothelial injury due to an increased frequency of thrombogenesis. Endothelin-1 (ET-1) is a vasoconstrictor whereas nitric oxide (NO) is an endothelial vasorelaxing peptide that is responsible for the inhibition of platelet adhesion.Aim:To evaluate serum levels of homocysteine (Hcy) and determine whether hyperhomocysteinemia is considered as a contributing risk factor for venous and arterial thromboses of BD, and to correlate serum levels of ET-1 and NO with disease activity.Materials and Methods:We measured serum levels of Hcy, ET-1, and nitrite (NO2−) in 25 patients who fulfilled the criteria of the International Study Group for BD, and compared them to those of 15 healthy control subjects. Levels of Hcy and ET-1 were measured by using enzyme-linked immunosorbent assay (ELISA), whereas serum nitrite (NO2−) levels were measured by using Griess reaction as an indicator for NO production. All the patients were screened for a history of venous thrombosis and subdivided into thrombotic and nonthrombotic subgroups according to their thrombotic history. Patients with BD were divided into two subgroups, active and inactive, according to their clinical and laboratory findings.Results:There were significant increases in serum levels of Hcy, ET-1, and nitrite in BD patients compared to those in controls. There was a significant increase in serum Hcy levels in thrombotic compared to nonthrombotic subgroups. Positive correlations were detected between the serum ET-1 and nitrite levels with disease activity in BD patients.Conclusion:Hyperhomocysteinemia may play some role in the development of venous and arterial thromboses in BD. Increased NO production might ave critical biological activities that are relevant to pathological events in the active period of the disease.

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“…Similarly, antioxidant vitamin A might counterbalance the deleterious effects of oxidant stress by not only scavenging free radicals but also regulating ROS generation and antioxidant enzyme activities that metabolize ROS [10,11].…”

Section: Introductionmentioning

confidence: 99%

DNA damage and its relationship with other oxidative stress parameters in Behcet’s disease

et al. 2010

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Behçet's disease (BD) is a multisystemic, chronic inflammatory, relapsing disorder that is characterized by oral/genital ulcerations, ocular, arthritic, vascular, and neurologic involvements. Recent findings suggest the role of increased oxidative stress and insufficient antioxidant defence system in BD pathogenesis. It has been proposed that the increase in phagocytic cell activity by triggering oxidative reactions in various targets such as lipids, proteins, and DNA leads to severe inflammatory and degenerative pathologies seen in BD In this study, oxidant/antioxidant status of patients with BD was evaluated in comparison with controls and in respect to disease activity by measuring serum nitrite/nitrate, vitamin A, malondialdehyde (MDA), 8-hydroxy deoxyguanosine (8-OHdG), and total sulfhydryl levels (T-SH). The increase in serum MDA and 8-OHdG levels (respectively 30.04 vs. 17.93 nmol/ml, P = 0.0004 and 1.60 vs. 1.03 ng/ml, P = 0.0019) and the decrease in T-SH levels of patients with BD in comparison with controls (0.69 vs. 0.76 mmol/l, P = 0.0085) all indicate the impaired oxidant/antioxidant status in BD. The positive correlation found between MDA/8-OHdG levels (P = 0.02), and the negative correlations both between T-SH/8-OHdG levels (P = 0.031) and T-SH/MDA levels (P = 0.009) show the concordance between the parameters evaluating oxidant-antioxidant status. Among the parameters used for evaluating oxidant/antioxidant status, serum 8-OHdG was the only one showing significantly higher levels in patients with clinically active disease in comparison (P = 0.004) to patients in inactive period. Therefore, 8-OHdG that is assessed for the fist time in BD with this study can be proposed as a more reliable indicator of oxidant stress in evaluating disease activity.

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Vitamin levels in Behçet's disease

Abstract: It is contemplated that measurement of such oxidative stress factors as MDA and NO and an accompanying evaluation of the antioxidant defense system can be significant in the diagnosis and treatment follow-up of Behçet's disease.

Cited by 12 publications

References 37 publications

Vitamin D deficiency in patients with Behcet’s disease

Vitamin D deficiency in patients with Behcet’s disease

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

DNA damage and its relationship with other oxidative stress parameters in Behcet’s disease

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