1999
DOI: 10.1159/000057473
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Vitamin Replacement Therapy in Renal Failure Patients

Abstract: Renal failure patients require vitamin replacement therapy that addresses the specialized needs of renal failure. Four factors including restricted diet, uremic toxins, drug-nutrient interactions, and in ESRD, the dialysis process, affect the normal absorption, retention and activity of necessary micronutrients which support all aspects of carbohydrate, protein, lipid and nucleic acid metabolism. Studies have shown that the typical renal failure diet is low in B vitamins, that uremic factors affect folate and … Show more

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Cited by 28 publications
(17 citation statements)
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“…The first dose was selected in agreement with recommendations of vitamin C replacement therapy in hemodialysis patients [19] and the second dose was chosen in the context of vitamin C use as adjuvant to erythropoietin [12,13,14]. …”
Section: Introductionmentioning
confidence: 99%
“…The first dose was selected in agreement with recommendations of vitamin C replacement therapy in hemodialysis patients [19] and the second dose was chosen in the context of vitamin C use as adjuvant to erythropoietin [12,13,14]. …”
Section: Introductionmentioning
confidence: 99%
“…Vitamins are not usually synthesized by the body so must be supplied in the diet 1 . Concern has existed for some time over the possibility that chronic hemodialysis patients are at high risk for the development of vitamin deficiencies because diets prescribed for kidney disease patients tend to be low in certain vitamins 2 , the dialysis procedure may result in clearance of vitamins from blood 2,3 , metabolites that accumulate in the uremic milieu may impair the proper utilization of vitamins 2,3 , spontaneous reductions in food intake due to uremia may lead to inadequate vitamin consumption 3 , and medications and/or illnesses common to hemodialysis patients may interfere with the absorption and/or activity of vitamins [2][3][4] .…”
Section: Introductionmentioning
confidence: 99%
“…Altered micronutrient status in hemodialysis patients is due to chronic kidney disease (CKD) itself, common comorbidities and iatrogenic factors including dialysis, restricted diets, drug-nutrient interactions and uremic toxins 13. Altered micronutrient status is reflected by abnormal metabolism, body stores, and serum and plasma levels of many vitamins and minerals 1, 2, 4.…”
Section: Introductionmentioning
confidence: 99%
“…Altered micronutrient status is reflected by abnormal metabolism, body stores, and serum and plasma levels of many vitamins and minerals 1, 2, 4. CKD patients are at high risk for cardiovascular, cerebrovascular, dietary deficiency and other chronic diseases owing to changes in intakes of vitamins and minerals, altered metabolism and the disease itself 2.…”
Section: Introductionmentioning
confidence: 99%
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