Vitamin requirements and induced nutritional imbalances as criteria in speciating psychrophobic yeasts

Travassos, L. R.; Mendonça, Lúcia Carla Vasconcelos de

doi:10.1007/bf02328109

Antonie van Leeuwenhoek

1972

DOI: 10.1007/bf02328109

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Vitamin requirements and induced nutritional imbalances as criteria in speciating psychrophobic yeasts

L. R. Travassos

Lúcia Carla Vasconcelos de Mendonça

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1975

2023

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Cited by 3 publications

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“…Species differentiation is based mainly on minimal temperature of growth and ability to form ascospores or pseudomycelia. In addition, some differences have been reported in nutritional requirements (22,23) and in cell size. Very few carbon sources are utilized for growth, and the fermentative and assimilatory reactions are nearly identical.…”

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Deoxyribonucleic Acid Base Composition and Deoxyribonucleic Acid/Deoxyribonucleic Acid Hybrid Formation in Psychrophobic and Related Yeasts

Mendonça-Hagler¹,

Phaff²

1975

International Journal of Systematic Bacteriology

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The deoxyribonucleic acid (DNA) base composition of several strains of the psyc hrop ho bic species Sacc haromy ces t el luris, Torulopsis pinto lopesii, T. bou inu, and Candida slooffii was found to be similar, DNA/DNA hybridization experiments by means of the nitrocellulose filter technique revealed high degrees of homology between the nuclear DNAs of all four species. On the basis of these findings, T. bovina is considered to be a synonym of T. pintolopesii; C. slooffii, which has certain distinct and reproducible properties, was reclassified as T . pintolopesii var. slooffii. Saccharornycopsis guttulata has been retained as a separate species because its guanine plus cytosine value is higher than that of the four species mentioned above and it has other distinct properties. The nonpsychrophobic species Torulopsis glabrata was included for comparison. The guanosine plus cytosine content of its DNA was approximately 7% higher than that of T. pintolopesii.Psychrophobic enteric yeasts occur in the alimentary canal of certain domestic and wild animals (22). Such yeasts have minimum temperatures for growth ranging from approximately 20 to 30 C, whereas their maximum limits are somewhere between 40 and 46 C, depending on species and strain differences. Since a significant number of yeast species are known with similar maxima but with much lower minimal growth temperatures, the principal characteristic of psychrophobic yeasts is their rather high minimal temperature of growth. The species normally included in this group are Saccharomyces telluris (17) and its imperfect form Torulopsis bouina (21), T . pintolopesii (18, -21), Candida slooffii (19), and Saccharomycopsis guttulata (13). Species differentiation is based mainly on minimal temperature of growth and ability to form ascospores or pseudomycelia. In addition, some differences have been reported in nutritional requirements (22, 23) and in cell size. Very few carbon sources are utilized for growth, and the fermentative and assimilatory reactions are nearly identical. The salient properties of these species are shown in Table 1. Also included is Torulopsis glabrata, not a psychrophobic but a thermophilic species, which is sometimes associated with urinary tract infections in humans. This species superficially resembles the other organisms. It was included in this study for that reason and it also served as a control.sidade Federal do Rio de Janeiro, G. B., Brazil.Present address: Instituto de Microbiologia da UniverBecause of the many apparent similarities among these species, it was decided to study their deoxyribonucleic acid (DNA) base compositions on a comparative basis and to perform DNA/DNA reassociation experiments so that genetic relatedness could be evaluated between strains with similar base compositions. Several strains of each species were included in the survey. MATERIALS AND METHODSOrganisms and growth conditions. The yeast strains designated IGC or CBS were obtained from the Instituto de Microbiologia of the Universidade Federal do Rio de Janeiro,...

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confidence: 99%

Deoxyribonucleic Acid Base Composition and Deoxyribonucleic Acid/Deoxyribonucleic Acid Hybrid Formation in Psychrophobic and Related Yeasts

Mendonça-Hagler¹,

Phaff²

1975

International Journal of Systematic Bacteriology

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Chemically defined media for growing anaerobic bacteria of the genus Veillonella

Lopes

Cruz

1976

Antonie van Leeuwenhoek

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A chemically defined medium for Veillonella parvula and V. alcalescens is described. Some nutritional aspects of the two strains used were examined: the optimum concentration of reducing agents, the requirements for amino acids, diamines, vitamins and other growth factors, and the conditions needed for well balanced nutrition. No specific requirements for single amino acids were observed. A combination of L-cysteine, DL-aspartic acid, L-glutamic acid, L-serine and L-tyrosine, promoted growth. In V. alcalescens, serine could substitute both arginine and tryptophan (or histidine). No growth was obtained with ammonium salts as the sole N source. Decarboxylation of L-ornithine, L-lysine and L-arginine was not demonstrated in the Veillonella parvula strain, which required putrescine or cadaverine for growth. Spermine, spermidine, L-lysine, L-ornithine and L-arginine, could not substitute putrescine in Veillonella parvula. Veillonella alcalescens, which does not require putrescine in the medium, was able to decarboxylate L-ornithine while forming putrescine.

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From antimicrobial to anticancer: the pioneering works of Prof. Luiz Rodolpho Travassos on bioactive peptides

Koskela,

Figueiredo

2023

Braz J Microbiol

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Prof. Luiz Rodolpho Travassos, a distinguished Brazilian scientist, was instrumental in fostering an interdisciplinary research approach that seamlessly combined microbiology and oncology. This work has opened new pathways into the understanding of tumorigenesis and aided in the development of innovative therapeutic tools. One significant area of his work has been the exploration of bioactive peptides, many of which were first identified for their antimicrobial properties. These peptides demonstrate promise as potential cancer therapeutics due to their selectivity, cost-effectiveness, ease of synthesis, low antigenicity, and excellent tissue penetration. Prof. Travassos’ pioneering work uncovered on the potential of peptides derived from microbiological sources, such as those obtained using phage display techniques. More importantly, in international cooperation, peptides derived from complementarity-determining regions (CDRs) that showed antimicrobial activity against Candida albicans further showed to be promising tools with cytotoxic properties against cancer cells. Similarly, peptides derived from natural sources, such as the gomesin peptide, not only had shown antimicrobial properties but could treat cutaneous melanoma in experimental models. These therapeutic tools allowed Prof. Travassos and his group to navigate the intricate landscape of factors and pathways that drive cancer development, including persistent proliferative signaling, evasion of tumor suppressor genes, inhibition of programmed cell death, and cellular immortality. This review examines the mechanisms of action of these peptides, aligning them with the universally recognized hallmarks of cancer, and evaluates their potential as drug candidates. It highlights the crucial need for more selective, microbiology-inspired anti-cancer strategies that spare healthy cells, a challenge that current therapies often struggle to address. By offering a comprehensive assessment of Prof. Travassos’ innovative contributions and a detailed discussion on the increasing importance of microbiology-derived peptides, this review presents an informed and robust perspective on the possible future direction of cancer therapy.

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Vitamin requirements and induced nutritional imbalances as criteria in speciating psychrophobic yeasts

Cited by 3 publications

References 5 publications

Deoxyribonucleic Acid Base Composition and Deoxyribonucleic Acid/Deoxyribonucleic Acid Hybrid Formation in Psychrophobic and Related Yeasts

Deoxyribonucleic Acid Base Composition and Deoxyribonucleic Acid/Deoxyribonucleic Acid Hybrid Formation in Psychrophobic and Related Yeasts

Chemically defined media for growing anaerobic bacteria of the genus Veillonella

From antimicrobial to anticancer: the pioneering works of Prof. Luiz Rodolpho Travassos on bioactive peptides

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