Vitamin supplementation for preventing miscarriage

Rumbold, Alice; Middleton, Philippa; Crowther, Caroline A

doi:10.1002/14651858.cd004073.pub2

Cited by 30 publications

(22 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The latest Cochrane database review on vitamin supplementation for preventing miscarriage concluded that taking any vitamin supplements prior to pregnancy or in early pregnancy does not prevent women experiencing miscarriage or stillbirth. On the other hand they admit that there is insufficient evidence to examine the effects of different combinations of vitamins on miscarriage, stillbirth or other maternal and infant outcomes [29]. In our study levels of vitamin C and markers of oxidative stress were similar in the two normal pregnancy groups which may be a consequence of a healthy diet in the not treated arm, but also a lack of beneficial effects of the supplement in question.…”

Section: Resultscontrasting

confidence: 49%

Antioxidant Status in Normal Pregnancy and Preeclampsia upon Multivitamin-Mineral Supplementation in the Region of Vojvodina

Ćebović¹,

Marić²,

Nikolić³

et al. 2013

IJBBB

View full text Add to dashboard Cite

Abstract-Normal pregnancy is associated with oxidative stress and this is even increased during preeclampsia (PE). The decrease in total antioxidant capacity is the pathophysiological basis for vitamin supplementation during pregnancy, but the beneficial effect of this approach is still unclear. Levels of creatinine, urea, cystatin, malondialdehyde (MDA), superoxide dysmutase activity (SOD), glutathione peroxidase (GSH-Px) activity and acidum ascorbicum were measured in the serums of all women. Mean MDA level in maternal plasma in normal pregnancies was significantly lower than in PE pregnancies (2,78 ±0.78 pmol/mg vs 3.20±0.91 pmol/mg, p< 0.05), as well as mean GSH-Px levels (811 ±206 U/l vs 1350±575 U/l, p< 0.05. Mean ascorbic acid values were significantly higher in normal than in PE pregnancies (9,85 ±2,43 mg/L vs 5.54±1.81 mg/L, p< 0.001), as well as mean SOD values (26.8 ±18.45% vs 12.3±10.3%, p< 0.001). There were no significant differences in normal pregnancy group with and without multivitamin supplementation. MDA levels were significantly lower in PE pregnancies with vitamin supplementation (2.99 ± 0.81 pmol/mg vs 3.42 ± 1.01 pmol/mg, p< 0.05), as well as GSC-Px levels (1200 ± 500 U/l vs 1500 ± 650 U/l, p< 0.05). Ascorbic acid values were significantly higher in the PE group with vitamin supplementation (6.16 ± 1.66 mg/L vs 4.92 ± 1.96 mg/L, p< 0.05), as well as SOD levels (13 ± 11.4 % vs 11.6 ± 9.2%, p< 0.001).

show abstract

Section: Resultscontrasting

confidence: 49%

Antioxidant Status in Normal Pregnancy and Preeclampsia upon Multivitamin-Mineral Supplementation in the Region of Vojvodina

Ćebović¹,

Marić²,

Nikolić³

et al. 2013

IJBBB

View full text Add to dashboard Cite

show abstract

“…Although several small-scale studies have indicated that the use of anti-inflammatory agents (aspirin) or anti-oxidants (vitamin C and E) may be beneficial if given early in pregnancy before the onset of symptoms, this remains to be confirmed in large-scale analyses [88].…”

Section: Therapeutic Possibilitiesmentioning

confidence: 99%

Disturbances in placental immunology: ready for therapeutic interventions?

Hahn

Gupta

Troeger

et al. 2006

Springer Semin Immun

View full text Add to dashboard Cite

Recent studies have provided new insight into aberrations in the immunological interplay between mother and fetus and their potential role in the development of recurrent fetal loss and preeclampsia. The action of anti-phospholipid antibodies in recurrent fetal loss is now proposed to involve the complement system, neutrophil activation and the production of TNFα by immune bystander cells. A clear involvement of the immune system is emerging in preeclampsia, involving mainly the innate arm, especially neutrophils. The activation of peripheral neutrophils by placentally released inflammatory debris triggers the induction of neutrophil extracellular traps (NETs), which may lead to an occlusion of the intervillous space, thereby further promoting a condition of placental hypoxia. It has, hence, been suggested that new therapeutic strategies be developed, including the possible use of TNFα antagonists in cases of recurrent miscarriage. These strategies need to be addressed with caution due to the possible induction of fetal congenital abnormalities.

show abstract

“…Indeed, although obstetricians have been using vitamin E for years in the hope of preventing abortion (SHUTE 1960), there is no evidence that taking antioxidant vitamin supplements, alone or in combination with other agents, prior to pregnancy or in early pregnancy, prevents miscarriage (Rumbold et al 2005). So, further studies are needed.…”

Section: Spontaneous Miscarriage and Recurrent Pregnancy Lossmentioning

confidence: 99%

Oxidative stress in pregnancy and fertility pathologies

Pereira

Martel

2014

Cell Biol Toxicol

View full text Add to dashboard Cite

Oxidative stress designates the state of imbalance between reactive oxygen species (ROS) production and antioxidant levels. In a healthy placenta, there is an increase in ROS production, due to formation of new tissues and inherent metabolism, but this is balanced by higher levels of antioxidants. However, this balance is lost in some situations, with a consequent increase in oxidative stress levels. Oxidative stress has been implicated in several placental disorders and pregnancy pathologies. The present review intends to summarize what is known about the relationship between oxidative stress and well-known pregnancy disorders.

show abstract

Vitamin supplementation for preventing miscarriage

Cited by 30 publications

References 98 publications

Antioxidant Status in Normal Pregnancy and Preeclampsia upon Multivitamin-Mineral Supplementation in the Region of Vojvodina

Antioxidant Status in Normal Pregnancy and Preeclampsia upon Multivitamin-Mineral Supplementation in the Region of Vojvodina

Disturbances in placental immunology: ready for therapeutic interventions?

Oxidative stress in pregnancy and fertility pathologies

Contact Info

Product

Resources

About