Vitamina D: fisiopatología y aplicabilidad clínica en pediatría

Aliberch, R.M. Masvidal; Gómez, Sandra Ortigosa; Mendoza, Manchay; Garcı́a-Algar, Óscar

doi:10.1016/j.anpedi.2012.05.019

Cited by 20 publications

(28 citation statements)

References 81 publications

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“…En nuestro estudio se documentó que la tercera parte de las madres presentaron sobrepeso u obesidad al inicio del embarazo, lo cual se incrementó significativamente al final del mismo. Aunque no se halló correlación entre el IMC materno al final del embarazo y los valores de 25OHD, se ha reportado que la deficiencia de vitamina D puede relacionarse con obesidad, para lo cual se han propuesto dos mecanismos: 1) que la grasa corporal excesiva secuestra la vitamina D circulante, 2) que la deficiencia de vitamina D aumenta el acúmulo de grasa en el organismo [26][27][28] , y 3) la asociación de sobrepeso/obesidad y resistencia a la insulina 29 . Elizondo, et al 22 evidenciaron que existe mayor prevalencia de deficiencia de 25OHD en el grupo de obesos, comparado con un grupo control de no obesos, pero en su estudio no se encontró una correlación significativa entre los niveles de 25OHD y el IMC de las madres al final del embarazo.…”

Section: Discussionunclassified

Deficiencia de vitamina D en madres y neonatos mexicanos

Ochoa-Correa

Hernández

Pérez

et al. 2017

GMM

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Section: Discussionunclassified

Deficiencia de vitamina D en madres y neonatos mexicanos

Ochoa-Correa

Hernández

Pérez

et al. 2017

GMM

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“…As for moderate deficiency, there is a risk of error, which can be reduced by considering the reference values of each laboratory; however, for research studies, the methods employed should be standardized. 6 …”

Section: Detection Methodsmentioning

confidence: 99%

“…1-OHase is also found in other tissues that express ViD receptors, such as the placenta, colon, activated mononuclear cells and osteoblasts, which could produce 1.25(OH) 2 D with local autocrine or paracrine function. 6 …”

Section: Physiology and Vitamin D Metabolismmentioning

confidence: 99%

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Deficiência de vitamina D na gravidez e o seu impacto sobre o feto, o recém‐nascido e na infância

Urrutia-Pereira

Solé

2015

Revista Paulista de Pediatria

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OBJECTIVE: Vitamin D deficiency (VDD) in pregnant women and their children is an important health problem with severe consequences for the health of both. Thus, the objectives of this review were to reassess the magnitude and consequences of VDD during pregnancy, lactation and infancy, associated risk factors, prevention methods, and to explore epigenetic mechanisms in early fetal life capable of explaining many of the non-skeletal benefits of vitamin D (ViD). DATA SOURCE: Original and review articles, and consensus documents with elevated level of evidence for VDD-related clinical decisions on the health of pregnant women and their children, as well as articles on the influence of ViD on epigenetic mechanisms of fetal programming of chronic diseases in adulthood were selected among articles published on PubMed over the last 20 years, using the search term VitD status, in combination with Pregnancy, Offspring health, Child outcomes, and Programming. DATA SYNTHESIS: The following items were analyzed: ViD physiology and metabolism, risk factors for VDD and implications in pregnancy, lactation and infancy, concentration cutoff to define VDD, the variability of methods for VDD detection, recommendations on ViD replacement in pregnant women, the newborn and the child, and the epigenetic influence of ViD. CONCLUSIONS: VDD is a common condition among high-risk pregnant women and their children. The routine monitoring of serum 25(OH)D3 levels in antenatal period is mandatory. Early preventive measures should be taken at the slightest suspicion of VDD in pregnant women, to reduce morbidity during pregnancy and lactation, as well as its subsequent impact on the fetus, the newborn and the child.

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“…El resto proviene de una aportación exógena a través de alimentos como el pescado, la yema de huevo o alimentos enriquecidos con la vitamina. Por lo que una radiación solar inadecuada reduce la síntesis de vitamina D. Esta síntesis depende de factores como la edad, el grado de pigmentación cutánea, el de exposición solar, el uso de protectores solares o la cantidad de luz UVB que llega a la superficie terrestre, la cual se afecta por la estación del año, la hora del día, la localización geográfica y la contaminación 3,28 .…”

Section: Introductionunclassified