Vitamins and the Premature

Orzalesi, M

doi:10.1159/000242744

Cited by 11 publications

(5 citation statements)

References 67 publications

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Section: Discussionmentioning

confidence: 99%

“…This is commonly observed in preterm neonates, probably because of the fact that their adipose tissue stores are limited, and so are (Orzalesi, 1987;Debier, 2007;Gitto et al, 2009) the a-tocopherol concentrations (a-tocopherol normally accumulates during the third trimester of pregnancy) (Mactier and Weaver, 2005). Both vitamins are regarded as important biological antioxidants and their supplementation in preterm neonates was documented many years ago (Orzalesi, 1987). Vitamin E supplementation has been implicated in the prevention of bronchopulmonary dysplasia and elevations in hemoglobin levels in preterm neonates (Petrich et al, 1976), while vitamin A has been shown to prevent chronic lung disease, bronchopulmonary dysplasia and sepsis (Tyson et al, 1999;Atkinson, 2001;Darlow and Graham, 2007).…”

Section: Discussionmentioning

confidence: 99%

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A double-blind, randomized clinical trial of the effect of ω-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition

et al. 2010

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Background/Objectives: The aim of this study was to research and draw conclusions about the effect of a parenteral nutrition (PN) fat emulsion, rich in o-3 fatty acids, on the antioxidant markers of preterm infants, when compared with a standard fat emulsion. This was a double-blind, parallel-group study conducted in Athens, Greece, using an equal randomization method. Subjects/Methods: Thirty-eight infants were selected using a double-blind method and a computer-generated randomization list. Both groups received PN, based on the same protocols. Group A received SMOFlipid fat emulsion, while group B received the standard fat emulsion (Intralipid). Serum levels of vitamin A, E and total antioxidant potential (TAP) were measured on days 0, 7 and 14 of PN support. Clinical and biochemical data were collected on days 0, 14 and on the day of discharge. Results: Serum levels of vitamin E and A were significantly increased in group A, while only vitamin A serum level was increased in group B on the fourteenth day (group A: vitamin E: P-value ¼ 0.002, vitamin A: P-value ¼ 0.000, group B: vitamin E: P-value ¼ 0.065, vitamin A: P-value ¼ 0.000). TAP was increased only in the intervention group (group A: P-value ¼ 0.000, group B: P-value ¼ 0.287). Mild anemia was developed in both groups, while no differences were detected in the infection rate, days of hospitalization, days of ventilator support and days of phototherapy. Conclusions: Oxidative stress was significantly reduced in those neonates fed with o-3 fatty acids, whereas no effect was observed in the neonates fed with standard lipids. Intervention had no effect on infants' growth and clinical outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A double-blind, randomized clinical trial of the effect of ω-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition

et al. 2010

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“…The necessity of fat-soluble vitamins supplementation in preterm neonates was documented many years ago [17]. Preterm infants are most likely to develop deficiencies in vitamins due to inadequate body stores.…”

Section: Discussionmentioning

confidence: 99%

Comparison of two types of TPN prescription methods in preterm neonates

et al. 2009

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“…Breast milk is the optimal nutrition for the premature infant as it consists of unique amounts and types of proteins, enzymes, micronutrients, lipids, and particularly long-chain polyunsaturated fatty acids, which are critical for growth and development (Heird, 2001;Koletzko et al, 2001;Larque et al, 2002). Additionally, breast milk supports the vulnerable premature infant by reducing the risk of infection and improving gastrointestinal function and the absorption of nutrients (Boersma & Lanting, 2000;Feist, Berger, & Speer, 2000;Orzalesi, 1987). Unfortunately, premature infants who would most benefit from breast milk often receive less such milk compared to full-term infants, placing them at even a higher risk (Killersreiter, Grimmer, Buhrer, Dudenhausen, & Oblade, 2002).…”

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confidence: 99%

Direct and indirect effects of breast milk on the neurobehavioral and cognitive development of premature infants

Feldman

Eidelman

2003

Developmental Psychobiology

195

133

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Eighty-six premature infants were tested to examine the effects of maternal breast milk on infant development. Infants were classified by breast-milk consumption during the hospitalization period (M = 57.4 days) into three groups: those receiving minimal (<25% of nutrition), intermediate (25-75%), and substantial (>75%) amounts of breast milk. Infants in the three groups were matched for birth weight, gestational age (GA), medical risk, and family demographics. At 37 weeks GA, mother-infant interaction was videotaped, maternal depression self-reported, and neurobehavioral maturation assessed by the Neonatal Behavior Assessment Seale (Brazelton, 1973). At 6 months corrected age, infants were tested with the Bayley II (Bayley, 1993). Infants receiving substantial amounts of breast milk showed better neurobehavioral profiles-in particular, motor maturity and range of state. These infants also were more alert during social interactions, and their mothers provided more affectionate touch. Higher maternal depression scores were associated with lower quantities of breast milk, longer latencies to the first breast-milk feeding, reduced maternal affectionate touch, and lower infant cognitive skills. Maternal affectionate touch moderated the relations between breast milk and cognitive development, with infants receiving a substantial amount of breast milk and frequent touch scoring the highest. In addition to its nutritional value, breast milk may be related to improved maternal mood and interactive behaviors, thereby indirectly contributing to development in premature infants.

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Vitamins and the Premature

Cited by 11 publications

References 67 publications

A double-blind, randomized clinical trial of the effect of ω-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition

A double-blind, randomized clinical trial of the effect of ω-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition

Comparison of two types of TPN prescription methods in preterm neonates

Direct and indirect effects of breast milk on the neurobehavioral and cognitive development of premature infants

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