Vitamins and Trace Elements

Shenkin, Alan; Roberts, Norman B.

doi:10.1016/b978-1-4160-6164-9.00031-7

Cited by 36 publications

(52 citation statements)

References 574 publications

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“…By contrast, meats and dairy products are poor in Cu, while mushrooms, dried fruits, legumes, whole-cereal grain products, peanut butter, nuts, organ meats (liver), and shellfish (crustaceans, oysters) have relatively high contents (Shenkin and Roberts, 2012;Barceloux, 1999d). Sources of Mn also include whole grain foods, nuts, leafy vegetables, as well as soy products and teas (Shenkin and Roberts, 2012;Barceloux, 1999e). Cereals (rice, grains, especially flour) and certain vegetables, legumes (especially peas and beans) also have high Mo content (Shenkin and Roberts, 2012;Barceloux, 1999f).…”

Section: Introductionmentioning

confidence: 92%

“…The diet constitutes the primary source of Co and Ni (Shenkin and Roberts, 2012;Moyer, 2012;Barceloux, 1999a,b). Of these, Ni is the most common as it is an important component of stainless steel (chromium being the other).…”

Section: Introductionmentioning

confidence: 99%

“…Zn is present in all types of food, with high protein items representing prominent sources (Shenkin and Roberts, 2012;Barceloux, 1999c). By contrast, meats and dairy products are poor in Cu, while mushrooms, dried fruits, legumes, whole-cereal grain products, peanut butter, nuts, organ meats (liver), and shellfish (crustaceans, oysters) have relatively high contents (Shenkin and Roberts, 2012;Barceloux, 1999d). Sources of Mn also include whole grain foods, nuts, leafy vegetables, as well as soy products and teas (Shenkin and Roberts, 2012;Barceloux, 1999e).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Northern Norway Mother-and-Child Contaminant Cohort (MISA) Study: PCA analyses of environmental contaminants in maternal sera and dietary intake in early pregnancy

Veyhe

Hofoss

Hansen

et al. 2015

International Journal of Hygiene and Environmental Health

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Northern Norway Mother-and-Child Contaminant Cohort (MISA) Study: PCA analyses of environmental contaminants in maternal sera and dietary intake in early pregnancy

Veyhe

Hofoss

Hansen

et al. 2015

International Journal of Hygiene and Environmental Health

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“…However, there is a dearth of data correlating blood markers with tissue levels. One study [ 71 ] compared serum and red cell folate results to the levels of folate in the subject ' s liver, the principal storage site of folate [ 1 ]. The study compared marker levels with the folate concentration in liver biopsy specimens in 45 alcoholic patients.…”

Section: Correlation With Liver Folatementioning

confidence: 99%

Red cell or serum folate: what to do in clinical practice?

Farrell¹,

Kirsch

Herrmann

2013

Clinical Chemistry and Laboratory Medicine

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Folate deficiency has been linked to diverse clinical manifestations and despite the importance of accurate assessment of folate status, the best test for routine use is uncertain. Both serum and red cell folate assays are widely available in clinical laboratories; however, red cell folate is the more time-consuming and costly test. This review sought to evaluate whether the red cell assay demonstrated superior performance characteristics to justify these disadvantages. Red cell folate, but not serum folate, measurements demonstrated analytical variation due to sample pre-treatment parameters, oxygen saturation of haemoglobin and haematocrit. Neither marker was clearly superior in characterising deficiency but serum folate more frequently showed the higher correlation with homocysteine, a sensitive marker of deficiency. Similarly, both serum and red cell folate were shown to increase in response to folic acid supplementation. However, serum folate generally gave the greater response and was able to distinguish different supplementation doses. The C677T polymorphism of methylenetetrahydrofolate reductase alters the distribution of folate forms in red cells and may thereby cause further analytical variability in routine red cell folate assays. Overall, serum folate is cheaper and faster to perform than red cell folate, is influenced by fewer analytical variables and provides an assessment of folate status that may be superior to red cell folate.

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“…A good example of this is alteration in micronutrient levels; micronutrients are essential biomolecules and elements that play vital physiologic role in the body. While significant decreases may not cause instant dramatic effects, it may initiates many devastating and pathologic manifestations, example of which is the carcinogenic process (Shenkin et al 2006). Many of the micronutrients known to play important role in maintaining the genome were significantly altered.…”

Section: Discussionmentioning

confidence: 99%

Administration of counterfeit sildenafil citrate to Wistar rats: impact on serum micronutrient levels

Iyanda

Oparinde

2014

International Journal of Biological Research

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Background: Counterfeit drugs have been recognized as a cause of many pathologic states, sometimes resulting in death. Even when their exposure does not lead to death, there is still the possibility of slight alteration in many physiologic processes in the body; namely digestion, absorption and homeostatic mechanisms. Objective: The objective of the study is to determine the impact of counterfeit sildenafil citrate on serum micronutrient levels in male Wistar rats. Method: Twenty-one rats (250 g) were randomly distributed equally into 3 groups. The first, second and third groups were administered with 25 mg/kg BW of fake sildenafil citrate, 25 mg/kg BW genuine sildenafil citrate and distilled water (control) respectively. The route of administration was by gastric gavage. The serum concentrations of trace elements and vitamins were estimated using the Atomic Absorption Spectrometry and High Performance Liquid Chromatography respectively. Statistical analysis of data was carried out by using analysis of variance. A p value of ≤ 0.05 was considered significant. Results: Results revealed that all the micronutrients were significantly different except thiamine, niacin, vitamin B12, Mn, Fe, Cr, Mo, Co, riboflavin, pyridoxine, pantothenic and vitamin D. All the animals survived till the end of the study. Conclusion:The implication of the results is that while fake drug exposure may not result in death, it may cause depletions in various micronutrients known for their vital roles in the body.

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Vitamins and Trace Elements

Cited by 36 publications

References 574 publications

The Northern Norway Mother-and-Child Contaminant Cohort (MISA) Study: PCA analyses of environmental contaminants in maternal sera and dietary intake in early pregnancy

The Northern Norway Mother-and-Child Contaminant Cohort (MISA) Study: PCA analyses of environmental contaminants in maternal sera and dietary intake in early pregnancy

Red cell or serum folate: what to do in clinical practice?

Administration of counterfeit sildenafil citrate to Wistar rats: impact on serum micronutrient levels

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