Vitamins as regulators of calcium-containing kidney stones — new perspectives on the role of the gut microbiome

Chmiel, John A.; Stuivenberg, Gerrit A.; Al, Kait F.; Akouris, Polycronis P.; Razvi, Hassan; Burton, Jeremy P.; Bjazevic, Jennifer

doi:10.1038/s41585-023-00768-5

Cited by 14 publications

(12 citation statements)

References 306 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Parathyroid hormone (PTH)-induced bone loss is also microbiota-dependent, with germ-free mice and antibiotic-treated mice protected from the effects of the hormone 38 . Bone health depends on gut barrier integrity as well, and bacteria within the Clostridium, Enterococcus, and Streptococcus genera have been implicated in the metabolism of vitamin A, which is known to improve barrier function 18 . Finally, proinflammatory bacteria such as Streptococcus species are postulated to contribute to joint pain by the secretion of immunologic factors that pass from the gut into the circulation 39 .…”

Section: The Gut-bone Axis: a Brief Overviewmentioning

confidence: 99%

“…Additionally, the microbiota is a key mediator of bone metabolism in fracture healing, osteoporosis, inflammatory bowel disease, and rheumatoid arthritis. The gut microbiota communicates with distant sites of bone metabolism through immune mediators, regulation of hormones, extracellular vesicles, short-chain fatty acids (SCFAs), vitamins, and aromatic amino acids, among other mechanisms [15][16][17][18][19] .…”

mentioning

confidence: 99%

See 1 more Smart Citation

The Microbial Revolution in the World of Joint Replacement Surgery

Srikrishnaraj,

Lanting,

Burton

et al. 2024

JBJS Open Access

Self Cite

View full text Add to dashboard Cite

Background: The prevalence of revision surgery due to aseptic loosening and periprosthetic joint infection (PJI) following total hip and knee arthroplasty is growing. Strategies to prevent the need for revision surgery and its associated health-care costs and patient morbidity are needed. Therapies that modulate the gut microbiota to influence bone health and systemic inflammation are a novel area of research. Methods: A literature review of preclinical and clinical peer-reviewed articles relating to the role of the gut microbiota in bone health and PJI was performed. Results: There is evidence that the gut microbiota plays a role in maintaining bone mineral density, which can contribute to osseointegration, osteolysis, aseptic loosening, and periprosthetic fractures. Similarly, the gut microbiota influences gut permeability and the potential for bacterial translocation to the bloodstream, increasing susceptibility to PJI. Conclusions: Emerging evidence supports the role of the gut microbiota in the development of complications such as aseptic loosening and PJI after total hip or knee arthroplasty. There is a potential for microbial therapies such as probiotics or fecal microbial transplantation to moderate the risk of developing these complications. However, further investigation is required. Clinical Relevance: Modulation of the gut microbiota may influence patient outcomes following total joint arthroplasty.

show abstract

Section: The Gut-bone Axis: a Brief Overviewmentioning

confidence: 99%

mentioning

confidence: 99%

The Microbial Revolution in the World of Joint Replacement Surgery

Srikrishnaraj,

Lanting,

Burton

et al. 2024

JBJS Open Access

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similarly, vitamin D deficiency, a nearly common feature in CKD, was also shown to impact gut microbiota diversity, causing intestinal barrier dysfunction [ 78 ]. Additionally, a deficiency in vitamin D may lead to elevated levels of parathyroid hormone, which can stimulate bone resorption and cause hypercalcemia and hypercalciuria, potentially increasing the risk of hyperoxaluria [ 79 ].…”

Section: The Interplay Between Oxalate and Ckd: A Vicious Cycle Of Sh...mentioning

confidence: 99%

Oxalate Homeostasis in Non-Stone-Forming Chronic Kidney Disease: A Review of Key Findings and Perspectives

Stepanova

2023

Biomedicines

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is a significant global public health concern associated with high morbidity and mortality rates. The maintenance of oxalate homeostasis plays a critical role in preserving kidney health, particularly in the context of CKD. Although the relationship between oxalate and kidney stone formation has been extensively investigated, our understanding of oxalate homeostasis in non-stone-forming CKD remains limited. This review aims to present an updated analysis of the existing literature, focusing on the intricate mechanisms involved in oxalate homeostasis in patients with CKD. Furthermore, it explores the key factors that influence oxalate accumulation and discusses the potential role of oxalate in CKD progression and prognosis. The review also emphasizes the significance of the gut–kidney axis in CKD oxalate homeostasis and provides an overview of current therapeutic strategies, as well as potential future approaches. By consolidating important findings and perspectives, this review offers a comprehensive understanding of the present knowledge in this field and identifies promising avenues for further research.

show abstract

“…The role of the gut microbiota in nephrolithiasis and the contribution of vitamins, including vitamin K, to urolithiasis are being reconsidered [15]. Vitamers of vitamin K work throughout the body to reduce soft-tissue calcification by activating carboxyglutamate (Gla) proteins, osteocalcin, and Matrix Gla protein (MGP).…”

Section: Introductionmentioning

confidence: 99%

Is a Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism a Risk Factor for Nephrolithiasis in Sarcoidosis?

Drent,

Wijnen,

Bekers

et al. 2024

IJMS

View full text Add to dashboard Cite

Sarcoidosis is a systemic inflammatory disorder characterized by granuloma formation in various organs. It has been associated with nephrolithiasis. The vitamin K epoxide reductase complex subunit 1 (VKORC1) gene, which plays a crucial role in vitamin K metabolism, has been implicated in the activation of proteins associated with calcification, including in the forming of nephrolithiasis. This study aimed to investigate the VKORC1 C1173T polymorphism (rs9934438) in a Dutch sarcoidosis cohort, comparing individuals with and without a history of nephrolithiasis. Retrospectively, 424 patients with sarcoidosis were divided into three groups: those with a history of nephrolithiasis (Group I: n = 23), those with hypercalcemia without nephrolithiasis (Group II: n = 38), and those without nephrolithiasis or hypercalcemia (Group III: n = 363). Of the 424 sarcoidosis patients studied, 5.4% had a history of nephrolithiasis (Group I), only two of whom possessed no VKORC1 polymorphisms (OR = 7.73; 95% CI 1.79–33.4; p = 0.001). The presence of a VKORC1 C1173T variant allele was found to be a substantial risk factor for the development of nephrolithiasis in sarcoidosis patients. This study provides novel insights into the genetic basis of nephrolithiasis in sarcoidosis patients, identifying VKORC1 C1173T as a potential contributor. Further research is warranted to elucidate the precise mechanisms and explore potential therapeutic interventions based on these genetic findings.

show abstract

Vitamins as regulators of calcium-containing kidney stones — new perspectives on the role of the gut microbiome

Cited by 14 publications

References 306 publications

The Microbial Revolution in the World of Joint Replacement Surgery

The Microbial Revolution in the World of Joint Replacement Surgery

Oxalate Homeostasis in Non-Stone-Forming Chronic Kidney Disease: A Review of Key Findings and Perspectives

Is a Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism a Risk Factor for Nephrolithiasis in Sarcoidosis?

Contact Info

Product

Resources

About