Vitamins C and E

Fragile X syndrome (FXS) is a debilitating genetic disorder with no cure and few therapeutic options. Excessive signaling through metabotropic glutamate receptor 5 in FXS leads to increased translation of numerous synaptic proteins and exaggerated long-term depression. Two of the overexpressed proteins are amyloid-beta protein precursor (APP) and its metabolite amyloid-beta, which have been well-studied in Alzheimer's disease (AD). Here we discus the possibility that pharmaceuticals under study for the modulation of these proteins in AD might be viable therapeutic strategies for FXS. Specifically, a recently identified acetyltransferase inhibitor that reduces the levels and activity of β-site APP cleaving enzyme (BACE-1) has strong potential to attenuate BACE-1 activity and maintain homeostatic levels APP catabolites in FXS.

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Vitamins C and E

Cited by 3 publications

References 97 publications

Extraction of Phenolic Compounds by Supercritical Fluid Extraction

Extraction of Phenolic Compounds by Supercritical Fluid Extraction

A Novel Synthesis of Gold Nanoparticles-Layered Double Hydroxides Nanocomposites Through In-situ Reductive Adsorption of Gold(III) Ion on Organic Acid-Functionalized Mg/Al Layered Double Hydroxides

Developing BACE-1 inhibitors for FXS

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