Vitamins C and E for the prevention of pre‐eclampsia: time to give up the ghost*

Talaulikar, Vikram; Manyonda, Isaac

doi:10.1111/j.1471-0528.2009.02280.x

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Millions of US dollars and research resources have passed since the Cochrane review [112] detailed that there was no significant difference between antioxidant and control groups for the relative risk of preeclampsia or any other analysed outcome thirteen years ago. Thus, Talaulikar and Manyonda [113] were arguably right when they suggested that it was time to "give up the ghost" on antioxidants for preeclampsia treatment/prevention twelve years ago. What is more surprising is that even though antioxidant treatment for preeclampsia has clearly failed, future trials involving antioxidant treatment (among other drugs) in complicated pregnancies are planned and several are expected to be completed in subsequent years (see Table 3).…”

Section: Discussionmentioning

confidence: 99%

Antioxidants in Pregnancy: Do We Really Need More Trials?

et al. 2022

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Human pregnancy can be affected by numerous pathologies, from those which are mild and reversible to others which are life-threatening. Among these, gestational diabetes mellitus and hypertensive disorders of pregnancy with subsequent consequences stand out. Health problems experienced by women during pregnancy and postpartum are associated with significant costs to health systems worldwide and contribute largely to maternal mortality and morbidity. Major risk factors for mothers include obesity, advanced maternal age, cardiovascular dysfunction, and endothelial damage; in these scenarios, oxidative stress plays a major role. Markers of oxidative stress can be measured in patients with preeclampsia, foetal growth restriction, and gestational diabetes mellitus, even before their clinical onset. In consequence, antioxidant supplements have been proposed as a possible therapy; however, results derived from large scale randomised clinical trials have been disappointing as no positive effects were demonstrated. This review focuses on the latest evidence on oxidative stress in pregnancy complications, their early diagnosis, and possible therapies to prevent or treat these pathologies.

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Section: Discussionmentioning

confidence: 99%

Antioxidants in Pregnancy: Do We Really Need More Trials?

et al. 2022

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Exercise as a therapeutic intervention to optimize fetal weight

Reyes

Davenport

2018

Pharmacological Research

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Serum Level and Antioxidant Activity of Ceruloplasmin in Preeclampsia

Shakour-Shahabi

Abbasalizadeh²,

Rashtchizadeh³

2010

Pakistan J. of Biological Sciences

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The antioxidants activities are decreased in the serum of women with preeclampsia. This study was aimed to determine the serum level and antioxidant activity of ceruloplasmin in preeclamptic women with gestational age over than 28 weeks. In a cross-sectional and descriptive-analytic study performed on 60 patients with preeclampsia (30 with mild and 30 with severe preeclampsia) and 30 women with normal pregnancy (control) in Tabriz al-Zahra Hospital, serum level and antioxidant activity of ceruloplasmin was evaluated. The mean gestational age was 32.94+/-2.79 week in mild preeclampsia group, 32.17+/-3.00 week in severe preeclampsia group and 32.46+/-4.04 week in control group (p = 0.821). The mean serum level of ceruloplasmin was 0.62+/-0.16 g L-1 in mild preeclampsia group, 0.61+/-0.23 g L-1 in severe preeclampsia group and 0.47+/-0.16 g L-1 in control group. The serum ceruloplasmin in control group was significantly lower (p = 0.006). The mean antioxidant activity of ceruloplasmin was 562.54+/-139.79 in mild preeclampsia group, 556.21+/-190.94 in severe preeclampsia group and 427.62+/-162.14 in control group. The antioxidant activity was measured as production of mg dL-1 of a colored product. The antioxidant activity of ceruloplasmin in control group patients was significantly lower (p = 0.002). Significant linear positive correlation was found between serum level of ceruloplasmin and antioxidant activity of ceruloplasmin (p<0.001 and r = 0.910). Serum level of ceruloplasmin is significantly lower in normal pregnancy than mild and severe preeclampsia. Antioxidant activity of ceruloplasmin is significantly lower in normal pregnancy than mild and severe preeclampsia.

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Vitamins C and E for the prevention of pre‐eclampsia: time to give up the ghost*

Cited by 3 publications

References 5 publications

Antioxidants in Pregnancy: Do We Really Need More Trials?

Antioxidants in Pregnancy: Do We Really Need More Trials?

Exercise as a therapeutic intervention to optimize fetal weight

Serum Level and Antioxidant Activity of Ceruloplasmin in Preeclampsia

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