Vitamins E plus C and interacting conutrients required for optimal health

Gey, K. F.

doi:10.1002/biof.5520070115

Cited by 181 publications

(14 citation statements)

References 370 publications

(488 reference statements)

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“…No changes on TEAC and phenolic compounds content were detected after ingestion of +NDF +PPJ bars. Similarly, no changes were detected on the levels of vitamin A and E after supplementation with +NDF tortillas or +NDF bars, which is consistent with previous reports [26]. Vitamin C levels in plasma showed an increase of 25% following the ingestion of +NDF tortillas (77.91 mmol/L) and +NDF bars (78.13 mmol/L) (Figure 1), which can be related to the absorption of this component supplied from the modified food or by a replacement effect of this vitamin by vitamin E, B or polyphenolic compounds [26].…”

Section: Resultssupporting

confidence: 92%

Biofunctional activity of tortillas and bars enhanced with nopal. Preliminary assessment of functional effect after intake on the oxidative status in healthy volunteers

Guevara-Arauza

Paz

Mendoza

et al. 2011

Chemistry Central Journal

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BackgroundPrickly pear cactus stem (nopal) has been used in folk medicine and a raw material since ancient times. Stems have been proved to possess components with valuable biological activities: anti inflamatory, antioxidant, antiulcerogenic, hypoglycemic, and so forth. Nowadays, people consume foods not only to cover the nutritional requirements, they also demand for healty, natural and convenient foods that show biological activity. This study evaluated the bio-functional effects of consuming tortillas or bars (filled with prickly pear fruit jam) supplemented or not with nopal dietary fiber.ResultsThe addition of nopal increased the fiber and polyphenols content in both tortillas (16.67%, 2.33 mg QE/L) and bars (13.79%, 1.99 mg QE/L). Furthermore the trolox equivalent antioxidant capacity (TEAC, 1.47 mmol/L), polyphenols (7.67 mg QE/L) and vitamin C (77.91 μmol/L) showed increased levels in volunteer's plasma after intake. Also lower levels of glucose (4.43 mmol/L), total cholesterol (4.27 mmol/L), LDL (1.96 mmol/L) and triglycerides (1.54 mmol/L) were observed in plasma after the supplementation scheme with nopal-based tortilla, while GSH:GSSG ratio in erythrocytes was higher.ConclusionsThe results suggested that the intake of nopal-based tortillas with high content in fiber and antioxidant compounds can help to improve the overall oxidative status in healthy humans, which can reduce the risk of some chronic diseases. In addition, these products showed suitable physicochemical characteristics to be marketed.

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Section: Resultssupporting

confidence: 92%

Biofunctional activity of tortillas and bars enhanced with nopal. Preliminary assessment of functional effect after intake on the oxidative status in healthy volunteers

Guevara-Arauza

Paz

Mendoza

et al. 2011

Chemistry Central Journal

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“…Recently, Langlois et al [46] proposed that plasma vitamin C should be considered as a predictor of cardiovascular disease in addition to being a classical nutritional biomarker. Based on a large number of studies including the famous Monica study [14, 18] performed on 14 European populations, plasma cutoff levels (4.4–7.0 mg/L or 25–40 μ M) in vitamin C have been proposed, above which the risk for apparent cardiovascular events should decrease. In haemodialysis patients, the cutoff value of 5.66 mg/L (32 μ M) was predictive of the appearance of adverse cardiovascular outcomes [47].…”

Section: Discussionmentioning

confidence: 99%

“…When compared to 3.66 mg/L, each 3.52 mg/L (20 μ M) rise in plasma ascorbic acid concentration was associated with about a 20% reduction in risk of all-cause mortality ( P < .0001), regardless of age, systolic blood pressure, blood cholesterol, cigarette smoking habit, diabetes, and supplement use. For β -carotene, Gey established that a plasma value below 0.22 mg/L (0.4 μ M) was associated with an increased risk of developing cardiovascular diseases and cancer [18]. …”

Section: Discussionmentioning

confidence: 99%

“…A few prospective, large-scale, European studies have shown a negative correlation between vitamin C plasma levels and all-cause or cardiovascular mortality. Plasma vitamin C levels below the normal range 4–8.8 mg/L (or 23–50 μ M) were found to double the risk of developing cardiovascular disease and cancer [14–18]. For β -carotene, the upper reference limit was estimated to be 0.22 mg/L (or 0.4 μ M) [18].…”

Section: Introductionmentioning

confidence: 99%

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Lifestyle Behaviours and Plasma Vitamin C andβ-Carotene Levels from the ELAN Population (Liège, Belgium)

Pincemaïl

Vanbelle

Degrune

et al. 2011

Journal of Nutrition and Metabolism

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Several factors, including fruit and vegetables intakes, have been shown to significantly influence the plasma concentrations of the two antioxidants vitamin C and β-carotene. Deficiency levels of 6 mg/L (34.2 μM) for vitamin C and of 0.22 mg/L (0.4 μM) for β-carotene have been suggested below which cardiovascular risk might be increased. The present study performed on 897 presumably healthy subjects aged 40–60 years aimed to examine how modifiable lifestyle factors may be related to vitamin C and/or β-carotene deficiency. Gender, smoking, lack of regular physical activity and of daily fruit consumption (≥2/day), and social status (in particular, unemployment) were found to be significant risk factors for vitamin C deficiency. For β-carotene deficiency, the same factors were identified except social status; moreover, overweight and OC use in women were also found to have a deleterious effect. For non exposed subjects, the probability of developing vitamin C deficiency was 4% in men and 2.4% in women. This probability increased to 66.3% for men and to 44.3% for women (and even to 50.4% under OC use), when all risk factors were present. For β-carotene deficiency, the corresponding probabilities were equal to 29.7% in men and 13.7% in women (no risk factor present), and to 86.1% for men and 69.9% (91.6% for OC use) for women (all factors present), respectively.

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“…Cut-points for the increased CHD risk remain to be firmly established for many of these factors but for lipid-standardized vitamin E and tHcy, cut-points of 5 μmol/mmol (18) and 15 μmol/L (19) have been suggested respectively. In the present study, using these cut-points, 69.6% and 11.1% of the population can be considered at an elevated risk of CHD based on lipid-standardized vitamin E and tHcy.…”

Section: Discussionmentioning

confidence: 99%

Status of Novel Cardiovascular Risk Factor and Cardiovascular Disease Risk in an Urban Cuban Population—A Pilot Study

Rodríguez-Ojea

Alonso

Yarnell

et al. 2011

J Health Popul Nutr

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Cardiovascular disease is the main cause of death in Cuba, yet the prevalence of novel risk factors is not known. To examine the prevalence of risk factors of traditional and novel cardiovascular diseases (CVDs) among an urban Cuban population, a cross-sectional pilot survey was undertaken in Havana city, Cuba. Ninety-seven adults aged 45-60 years registered to receive medical care at a policlinic. The prevalences of rates of CVD risk factors were: hypertension (≥140/90 mmHg) (53.6%), hypercholesterolaemia (total cholesterol >5.2 mmol/L) (47.0%), low high-density lipoprotein (HDL)-cholesterol (<1.03 mmol/L) (64.3%); diabetes (self-reported) (24.6%); metabolic syndrome (ATP III criteria) (58.2%); overweight and obesity (body mass index ≥25 kg/m2) (78.0%); current smoking (39.3%); elevated level of C-reactive protein (3 15 μmol/L) (11.1%). The total carotenoid status was independently associa-ted with waist-circumference and risk of diabetes and metabolic syndrome. In this small unrepresentative sample of people aged 40-65 years from Havana city, there was a high prevalence of traditional and novel CVD risk factors. The total serum carotenoid status appeared to be associated with an increased prevalence of CVD risk factors.

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Vitamins E plus C and interacting conutrients required for optimal health

Abstract: In CVD vitamin E acts as first risk discriminator, vitamin C as second one; optimal health requires synchronously optimized vitamins C + E, A, carotenoids and vegetable conutrients.

Cited by 181 publications

References 370 publications

Biofunctional activity of tortillas and bars enhanced with nopal. Preliminary assessment of functional effect after intake on the oxidative status in healthy volunteers

Biofunctional activity of tortillas and bars enhanced with nopal. Preliminary assessment of functional effect after intake on the oxidative status in healthy volunteers

Lifestyle Behaviours and Plasma Vitamin C andβ-Carotene Levels from the ELAN Population (Liège, Belgium)

Status of Novel Cardiovascular Risk Factor and Cardiovascular Disease Risk in an Urban Cuban Population—A Pilot Study

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