Vitellogenin induction in painted turtle, Chrysemys picta, as a biomarker of exposure to environmental levels of estradiol

Irwin, Lisa K.; Gray, Sandra L.; Oberdörster, Eva

doi:10.1016/s0166-445x(01)00159-x

Cited by 115 publications

(78 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The EDCs analyzed in this study have been linked with extraordinary estrogenic activity and organism reproductive disorders in aquatic environments [2][3][4][5][6][7][8]. To assess potential impacts, the concentrations of these EDCs can be expressed as 17b-estradiol equivalents based on each EDC's relative estrogenic potency (E2 is assigned a potency of 1) [26].…”

Section: Distribution Of Edcs In the Water Samples And Risk Assessmentmentioning

confidence: 99%

“…To assess potential impacts, the concentrations of these EDCs can be expressed as 17b-estradiol equivalents based on each EDC's relative estrogenic potency (E2 is assigned a potency of 1) [26]. Low concentrations of E2 at 1 ng/L led to the induction of vitellogenin in male trout [3], whereas female turtles (Chrysemys picta) were also affected by increasing plasma vitellogenin levels after exposure to E2 concentrations ranging from 0.05 to 1.80 ng/L in a field study [5]. Furthermore, Young et al [27] proposed a tentative long-term predicted no effect concentration for freshwater life of 1 ng/L for E2.…”

Section: Distribution Of Edcs In the Water Samples And Risk Assessmentmentioning

confidence: 99%

“…Among these classes of chemicals, steroid estrogens (such as estrone [E1], 17b-estradiol [E2], and 17a-ethynylestradiol [EE2]) and phenolic xenoestrogens (such as alkylphenols and bisphenol A [BPA]) deserve particular attention because the former possesses the highest estrogenicity and the latter has moderate estrogenic potency and widespread applications. Their adverse effects on the reproductive functions of aquatic species (e.g., feminization of male fish, snail, and tadpoles, and induction of vitellogenin for male fish and turtle) and influence on humans (e.g., breast cancer) have been observed worldwide [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of endocrine‐disrupting chemicals with total organic carbon in riverine water and suspended particulate matter from the Pearl River, China

Gong

Ran

Chen

et al. 2012

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Abstract-The distribution of endocrine-disrupting chemicals (EDCs) and its relationship with dissolved and particulate organic carbon (DOC and POC) was investigated in selected rivers of the Pearl River Delta, South China. The aqueous concentrations (average; ng/L) and particulate concentrations (average; ng/g, dry wt) for 4-tert-octylphenol (OP), 4-nonylphenol (NP), bisphenol A (BPA), and estrone (E1) were in the ranges of not detectable to 153 (31.8), 276 to 2,457 (1,178), 8.4 to 628 (161), and less than 1.5 to 11.5 (3.2), respectively, and 4.4 to 402 (98.1), 342 to 12,053 (4,922), 12.3 to 758 (128), and not detectable to 14.4, respectively. The highly significant correlation of EDCs with DOC and POC, and the similar regression slopes, implied the critical importance of DOC and POC on the distribution, transport, and fate of EDCs in the aquatic environment. The in situ particle-water partition coefficients (log K OC ) for OP (4.89 AE 0.41), NP (5.05 AE 0.33), and BPA (4.34 AE 0.50) were close to those reported by other field studies, but one to two orders of magnitude higher than those predicted with n-octanol-water partition coefficient (K OW ). The higher K OC values were attributed to the combined effects of low EDC concentrations, nonlinear sorption, and heterogeneity of POC and DOC. Moreover, a regression between in-situ K OC and K OW for phenolic xenoestrogens was observed (log K OC ¼ 0.625 Â log K OW þ 2.28, r 2 ¼ 0.99), suggesting that hydrophobicity contributed predominantly to the overall sorption of OP, NP, and BPA. Environ. Toxicol. Chem. 2012;31:245631: -246431: . # 2012

show abstract

Section: Distribution Of Edcs In the Water Samples And Risk Assessmentmentioning

confidence: 99%

Section: Distribution Of Edcs In the Water Samples And Risk Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of endocrine‐disrupting chemicals with total organic carbon in riverine water and suspended particulate matter from the Pearl River, China

Gong

Ran

Chen

et al. 2012

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…Vitelogenina é uma proteína que desempenha um importante papel no sistema reprodutivo de vertebrados ovíparos fêmeas. É sintetizada no fígado, regulada por estrogênio e transportada através do sangue para os ovários, onde serão incorporados no desenvolvimento dos óvulos [64][65][66] . De um modo geral, o gene do VTG também está presente em organismos machos, mas sob condições normais não é expressivo, possivelmente, pela baixa concentração de estrogênio no sangue 63 .…”

Section: Possíveis Efeitos De Fármacos No Meio Ambienteunclassified

Fármacos no meio ambiente

Bila¹,

Dezotti²

2003

Quím. Nova

212

View full text Add to dashboard Cite

. Patients and animals excrete part of pharmaceuticals used for human and veterinary medicine after administration in domestic sewage or on the soil. Drugs residues which have not been completely removed during passage through a sewage treatment plant (STP) enter the aquatic environment. The effects of such residual drugs in terrestrial and aquatic organisms are scarcely known.Keywords: pharmaceutical drugs; water pollution; environment fate. , 50% a 90% de uma dosagem do fármaco é excretado inalterado e persiste no meio ambiente. O uso desenfreado de antibióticos acarreta dois problemas ambientais: um, é a contaminação dos recursos hídricos e o outro, é que alguns microorganismos criam resistência a esses fármacos. As bactérias podem fazer, e freqüentemente o fazem, mudanças no seu material genético, adquirindo resistência aos fármacos. Assim, uma bactéria presente em um rio que contenha traços de antibióticos pode adquirir resistência a essas substâncias 23 . De acordo com Kummerer 24 alguns grupos de fármacos residuais merecem uma atenção especial, dentre eles estão os antibióticos e os estrogênios. Os antibióticos têm sido amplamente discutidos na literatura, devido ao seu potencial de desenvolvimento de bactérias resistentes no meio ambiente 23,25-28 e por serem usados em grandes quantidades, tanto na medicina humana, quanto na medicina veterinária (crescimento do gado, na aquicultura e produção avícola e suína) [29][30][31] . A importância dos estrogênios reside no seu potencial de afetar adversamente o sistema reprodutivo de organismos aquáticos como, por exemplo, a feminização de peixes machos presentes em rios contaminados com descarte de efluentes de ETEs 32-37 . A presença desses fármacos residuais na água pode causar efeitos adversos na saúde, seja humana ou de outros organismos presentes nas águas, como os peixes. Os efeitos causados no sistema reprodutivo de organismos aquáticos são demonstrados em alguns estudos 33,36,37 . Kang et al. 36 e Gimeno et al. 37 examinaram o efeito do estrogênio natural 17 β-estradiol no sistema reprodutor dos peixes. Sumpter 33 descreve a feminização de peixes machos expostos a estrogênios lançados nos rios através dos efluentes de ETE. INTRODUÇÃOAtualmente, existe uma preocupação no desenvolvimento de mé-todos analíticos suficientemente sensíveis na determinação dos fármacos residuais em ambientes aquáticos, com limites de detecção na ordem de µg/L e ng/L 4,6,7,38 . OCORRÊNCIA DE FÁRMACOS EM AMBIENTES AQUÁTICOSAlgumas toneladas de medicamentos são produzidas por ano e aplicadas na medicina humana e veterinária. Geralmente, a produção exata não é publicada na literatura.A ocorrência de fármacos residuais no esgoto doméstico e águas naturais é um importante tópico internacional. Estudos demonstram que esses fármacos e seus metabólitos estão presentes em ambientes aquáticos em várias partes do mundo, como Alemanha 3,4,6,10,12,18

show abstract

“…EDCs consist of a wide range of natural and man-made chemicals, most of which are released to natural waters by anthropogenic activities and whose adverse effects on normal reproductive functions of aquatic species have widely been confirmed (Jobling et al, 1996;Routledge et al, 1998;Oehlmann, 2000;Irwin et al, 2001;Levy et al, 2004). For instance, widespread estrogenic chemical input has been regarded as an important factor related to the decline of fish abundance in freshwater systems (Jobling et al, 1998;Burkhardt-Holm et al, 2005;Kidd et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Occurrence of endocrine-disrupting chemicals in riverine sediments from the Pearl River Delta, China

Gong

Ran

Chen

et al. 2011

Marine Pollution Bulletin

View full text Add to dashboard Cite

Vitellogenin induction in painted turtle, Chrysemys picta, as a biomarker of exposure to environmental levels of estradiol

Cited by 115 publications

References 29 publications

Association of endocrine‐disrupting chemicals with total organic carbon in riverine water and suspended particulate matter from the Pearl River, China

Association of endocrine‐disrupting chemicals with total organic carbon in riverine water and suspended particulate matter from the Pearl River, China

Fármacos no meio ambiente

Occurrence of endocrine-disrupting chemicals in riverine sediments from the Pearl River Delta, China

Contact Info

Product

Resources

About