Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials

Csupor, Dezső; Lantos, Tamás; Hegyi, Péter; Benkő, Ria; Viola, Réka; Gyöngyi, Zoltán; Csécsei, Péter; Tóth, Barbara; Vasas, Andrea; Korbonits, M; Rostás, Ildikó; Szentesi, Andrea; Matuz, Mária

doi:10.1016/j.ctim.2019.08.024

Cited by 32 publications

(23 citation statements)

References 26 publications

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“…The mechanisms of these buckwheat effects remain unknown. The stimulatory action of vitex on ovarian cell viability, proliferation, apoptosis, and 17 β -estradiol release is concordant with previous indications on its ability to increase ovarian cell apoptosis [ 41 , 42 ] and steroidogenesis [ 36 , 37 , 38 , 39 , 40 ]. Furthermore, there is the first evidence on the capability of vitex to promote ovarian cell proliferation, resulting in cell turnover and viability.…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore, there is the first evidence on the capability of vitex to promote ovarian cell proliferation, resulting in cell turnover and viability. These effects explain the stimulatory and therapeutic action of vitex on some ovarian functions reported previously [ 36 , 37 , 38 , 39 , 40 ].…”

Section: Discussionsupporting

confidence: 65%

“…Vitex ( Vitex agnus-castus ) is another potential regulator of reproduction and health. The presence of antioxidants and phytoestrogens in vitex makes it useful for the treatment of polycystic ovarian syndrome and the restoration of sex steroid release and estrous cycle [ 36 , 37 , 38 ], for the therapy of premenstrual and postmenstrual syndromes [ 39 , 40 ] and as a remedy for infertility [ 39 ]. Due to its ability to promote apoptosis, it can be also beneficial for the prevention and cure of cancer [ 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

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Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals

et al. 2020

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The application of nanoparticles has experienced a vertiginous growth, but their interaction with food and medicinal plants in organisms, especially in the control of reproduction, remains unresolved. We examined the influence of copper nanoparticles supported on titania (CuNPs/TiO2), plant extracts (buckwheat (Fagopyrum esculentum) and vitex (Vitex agnus-castus)), phytochemicals (rutin and apigenin), and their combination with CuNPs/TiO2 on ovarian cell functions, using cultured porcine ovarian granulosa cells. Cell viability, proliferation (PCNA accumulation), apoptosis (accumulation of bax), and hormones release (progesterone, testosterone, and 17β-estradiol) were analyzed by the Trypan blue test, quantitative immunocytochemistry, and ELISA, respectively. CuNPs/TiO2 increased cell viability, proliferation, apoptosis, and testosterone but not progesterone release, and reduced the 17β-estradiol output. Plant extracts and components have similar stimulatory action on ovarian cell functions as CuNPs/TiO2, but abated the majority of the CuNPs/TiO2 effects. This study concludes that (1) CuNPs/TiO2 can directly stimulate ovarian cell functions, promoting ovarian cell proliferation, apoptosis, turnover, viability, and steroid hormones release; (2) the plants buckwheat and vitex, as well as rutin and apigenin, can promote some of these ovarian functions too; and (3) these plant additives mitigate the CuNPs/TiO2’s activity, something that must be considered when applied together.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

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Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals

et al. 2020

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“…Many clinical trials confirm the health-promoting effects of V. agnus-castus L. [101][102][103][104][105][106][107][108]. Table 3 reports the results of the main clinical trial studies.…”

Section: Health-promoting Activities Of Vitex Agnus-castus L In Humamentioning

confidence: 99%

Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives

Souto

Durazzo²,

Nazhand

et al. 2020

Forests

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Medicinal plants are used worldwide due to their lower risk of side effects and eco-friendly, cost-effective production when compared to chemical drugs, encouraging researchers to further exploit the therapeutic potential of the former. One of the most popular medicinal plants is Vitex agnus-castus L., grown in tropical and sub-tropical regions, to which different health benefits have already been attributed. In this perspective article, the in vitro and in vivo therapeutic properties of V. agnus-castus L. have been analyzed and reviewed with a special focus on its health-promoting effects and potential nutraceutical applications.

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“…[ 7 ] One of these widely used plants is Vitex agnus-castus L. from the Verbenaceae family. [ 8 ] In traditional medicine, it is used to treat premenstrual syndrome and dysphoric mood disorders,[ 9 ] dysmenorrhea,[ 10 ] hyperprolactinemia, menopausal disorders,[ 11 ] lactation problems, and infertility. [ 12 ] Although its exact mechanism has not been established, it seems to affect the hypothalamic–pituitary axis and consequently reduce the release of follicle-stimulating hormone (FSH) and prolactin, and modulate the release of luteinizing hormone (LH) from the pituitary gland.…”

Section: Introductionmentioning

confidence: 99%

The 4-month effect of Vitex agnus-castus plant on sexual function of women of reproductive age: A clinical trial

Heirati

Ozgoli

Kabodmehri

et al. 2021

J Edu Health Promot

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BACKGROUND: Sexual dysfunction in women is a common disorder. Yet, there is no consensus on its treatment. Few studies have shown that Vitex agnus-castus improves sexual dysfunction in postmenopausal women; the present study was conducted to evaluate the effect of V. agnus-castus on the female sexual function in the reproductive age. MATERIALS AND METHODS: This was a double-blinded randomized control clinical trial on the women of reproductive age referred to the gynecology clinic of Al-Zahra Medical Center in Rasht, Iran, from February 2018 to December 2019. The intervention group received Agnugol tablet containing 3.2–4.8 mg dried extract V. agnus-castus (51 participants) and the control group received a placebo tablet (51 participants). All participants received one tablet daily for 16 weeks. The participants were asked to complete the Female Sexual Function Index questionnaire at the beginning of the study and after 4, 8, 12, and 16 weeks. Data were analyzed in SPSS statistics (version 21) using Chi-square test, t -test, Mann–Whitney U-test, analysis of variance, and mixed model to examine the differences between the groups. RESULTS: The results showed that the difference between the two groups was not significant in each domain, but there was a significant difference in the overall sexual function mean score so that the intervention group had a higher score than the placebo group after 16 weeks ( P < 0.05). CONCLUSION: In the present study, it was observed that the consumption of V. agnus-castus during 16 weeks was more effective than the placebo in improving sexual dysfunction. Further studies with larger sample sizes are needed to be able to decide on the prescription of this drug in the clinics.

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Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials

Cited by 32 publications

References 26 publications

Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals

Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals

Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives

The 4-month effect of Vitex agnus-castus plant on sexual function of women of reproductive age: A clinical trial

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