Vitexicarpin Induces Apoptosis in Human Prostate Carcinoma PC-3 Cells through G2/M Phase Arrest

Inhibitory Effects of Phenolic Alkaloids of Menispermum Dauricum on Gastric Cancer in Vivo

“…Chinese traditional medicine with abundant theoretical foundations and widely proven safety has been applied in more and more cancer researches. Several Chinese traditional medicines or their bioactive constituents including Scutellaria barbata D. Don (S. barbata), vitexicarpin and β-asarone have been shown to inhibit experimental tumorigenesis (Meng et al, 2012;Zou et al, 2012). In our study, we also demonstrated that PAMD, a Chinese traditional medicine, had an anti-tumor effect on mice with gastric cancer.…”

RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy

“…It has been reported that excessive ROS production leads to oxidative damage and acts on Bcl-2 family proteins that regulate apoptosis. 42 Therefore, the question of whether pGNRs@mSiO 2 -RGD nanoprobes target specific intracellular proteins and the underlying molecular mechanisms deserves further investigation.…”

Synergistic Anti-tumor Effect of KLF4 and Curcumin in Human Gastric Carcinoma Cell Line

“…Western blotting result implied that the levels of p-PI3K, cyclinD1 and p-ERK in KLF4, curcumin and their combination were plummeting compared with the control, and the combination of KLF4 overexpression and curcumin lead notable decrease of p-PI3K, cyclinD1 and p-ERK. These findings indicated that KLF4 and curcumin can effectively inhibit the proliferation of human gastric cancer BGC-823 cells by regulating PI3K/Akt and ERK/MAPK single pathways and arrested cell cycle at G1 period by downregulating the expression of cyclinD1 (Meng et al, 2012). The combination of KLF4 overexpression and curcumin play a better role than either of them individually.…”

“…The further study on evaluating apoptotic proteins levels of BAX and Bcl-2 arrived at the consistent conclusion. JNK/MAPK signal pathway play crucial roles in tumor cell apoptosis (Meng et al, 2012;You et al, 2013;Bloch et al, 2014). p-JNK levels of KLF4 overexpression cells, curcumin treated cells and co-treated cells were notable less than the control.…”