Vitexin alleviates breast tumor in mice via skewing TAMs toward an iNOS+ profile orchestrating effective CD8+ T cell activation

Chen, Yonger; Yuan, Xin; Pei, Chaoying; Deng, Zilu; Du, Xiongming; Liang, Jian; He, Lian; Hou, Shaozhen

doi:10.1016/j.jff.2022.105190

Cited by 5 publications

(2 citation statements)

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“…64 Similarly, vitexin promotes apoptosis and cell cycle arrest. 65 In the present study, elevated expression of BRCA1, cMYC, EpCAM, iCAM, MMP9, iNOS, and NFkB in the mammary tissues of the tumor group was observed. In contrast, mRNA expression of tumour suppressor gene BRCA1 was downregulated in the case of niosome treated groups.…”

Section: Materials Advances Papersupporting

confidence: 58%

Epidermal growth factor receptor targeted doxorubicin and vitexin loaded niosomes for enhanced breast cancer therapy

Malathi,

Sisila,

Singaravel

et al. 2023

Mater. Adv.

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Section: Materials Advances Papersupporting

confidence: 58%

Epidermal growth factor receptor targeted doxorubicin and vitexin loaded niosomes for enhanced breast cancer therapy

Malathi,

Sisila,

Singaravel

et al. 2023

Mater. Adv.

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“…[10,11] Vitexin, an apigenin flavone glucoside, is a key component of several edible and medicinal plants such as pearl millet and chasteberry. [12] It has been reported to exhibit antioxidant, anticonvulsant, antiinflammatory activity, and to regulate neuroinflammation [13,14] and have antidiabetic properties. [15] The lignans yangambin and epiyangambin are found in medicinal plants of several families including the Lauraceae [16] and Asteraceae.…”

Section: Introductionmentioning

confidence: 99%

Human Metabolism and Excretion of Kawakawa (Piper excelsum) Leaf Chemicals

Jayaprakash,

Pook,

Ramzan

et al. 2024

Molecular Nutrition Food Res

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ScopePiper excelsum (kawakawa) has a history of therapeutic use by Māori in Aotearoa New Zealand. It is currently widely consumed as a beverage and included as an ingredient in “functional” food product. Leaves contain compounds that are also found in a wide range of other spices, foods, and medicinal plants. This study investigates the human metabolism and excretion of kawakawa leaf chemicals.Methods and resultsSix healthy male volunteers in one study (Bioavailability of Kawakawa Tea metabolites in human volunteers [BOKA‐T]) and 30 volunteers (15 male and 15 female) in a second study (Impact of acute Kawakawa Tea ingestion on postprandial glucose metabolism in healthy human volunteers [TOAST]) consume a hot water infusion of dried kawakawa leaves (kawakawa tea [KT]). Untargeted Liquid Chromatography‐Tandem Mass spectrometry (LC‐MS/MS) analyses of urine samples from BOKA‐T identified 26 urinary metabolites that are significantly associated with KT consumption, confirmed by the analysis of samples from the independent TOAST study. Seven of the 26 metabolites are also detected in plasma. Thirteen of the 26 urinary compounds are provisionally identified as metabolites of specific compounds in KT, eight metabolites are identified as being derived from specific compounds in KT but without resolution of chemical structure, and five are of unknown origin.ConclusionsSeveral kawakawa compounds that are also widely found in other plants are bioavailable and are modified by phase 1 and 2 metabolism.

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