Vitiligo: A comprehensive overview

Felsten, Lesley M.; Alikhan, Ali; Petronic‐Rosic, Vesna

doi:10.1016/j.jaad.2010.10.043

Cited by 152 publications

(54 citation statements)

References 176 publications

(201 reference statements)

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“…Topical steroids are impractical when large surface areas are affected, and carry risk of systemic absorption with suppression of the adrenal axis, in addition to striae and skin atrophy (1). Topical calcineurin inhibitors appear to have fewer risks but are costly, less effective, and treat only focal disease (17). Systemic immunosuppression has been reported to halt the progression of vitiligo and reverse disease through repigmentation (18), however the risks associated with a non-targeted systemic approach are substantial, and usually deemed unacceptable when compared to the benefits.…”

Section: Introductionmentioning

confidence: 99%

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

et al. 2014

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Vitiligo is an autoimmune disease of the skin that results in disfiguring white spots. There are no FDA-approved treatments for vitiligo, and most off-label treatments yield unsatisfactory results. Vitiligo patients have increased numbers of autoreactive, melanocyte-specific CD8+ T cells in the skin and blood, which are directly responsible for melanocyte destruction. Here we report that gene expression in lesional skin from vitiligo patients reveals an IFN-γ-specific signature, including the chemokine CXCL10. CXCL10 is elevated in both vitiligo patient skin and serum and CXCR3, its receptor, is expressed on pathogenic T cells. To address the function of CXCL10 in vitiligo, we employed a mouse model of disease that also exhibits an IFN-γ-specific gene signature, expression of CXCL10 in the skin, and upregulation of CXCR3 on antigen-specific T cells. Mice that receive Cxcr3−/− T cells develop minimal depigmentation, as do mice lacking Cxcl10 or treated with CXCL10 neutralizing antibody. CXCL9 promotes autoreactive T cell global recruitment to the skin but not effector function while, in contrast, CXCL10 is required for effector function and localization within the skin. Surprisingly, CXCL10 neutralization in mice with established, widespread depigmentation induces reversal of disease, evidenced by repigmentation. These data identify a critical role for CXCL10 in both the progression and maintenance of vitiligo, and thereby support inhibiting CXCL10 as a targeted treatment strategy.

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Section: Introductionmentioning

confidence: 99%

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

et al. 2014

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“…These include topical medications such as corticosteroids or immunomodulators, phototherapy, oral medications, autologous melanocyte or epidermal transplant, surgery, and depigmentation [7]. While these therapies are important components in the treatment of vitiligo, the role of dietary modification and supplementation is often overlooked [1,8]. Recent studies have shown that alterations in dietary intake and oral supplementation can be beneficial in the treatment of many diseases, including vitiligo.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Dietary Supplementation in the Treatment of Vitiligo

Smith¹,

Mohammad²,

Hamzavi³

2017

TODJ

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Background:Vitiligo is the most common acquired pigmentary disorder in the world. Due to alterations in physical appearance, vitiligo is a psychologically devastating disease. Although treatment options exist, a cure for this disease has yet to be discovered. Of recent interest in vitiligo is the relationship between diet and disease. Objective:To review various dietary modifications and supplementation used in the management of vitiligo. Materials and Methods:A thorough evaluation of recent literature using the keywords "vitiligo, diet, supplement, antioxidant, vitamin, mineral, zinc, copper, gluten-free, celiac disease, alternative medicine" in the NCBI PubMed search function was performed. Results:A total of 39 relevant articles were reviewed and critically evaluated. Conclusion:Initial studies regarding the treatment of vitiligo through dietary modification are promising, although further studies are needed in multiple populations to explore the therapeutic value of these interventions.

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“…Surgical options include epidermal grafting and melanocyte suspension transplantation. Alternative options such as camouflage and depigmentation are also available [2]. …”

Section: Introductionmentioning

confidence: 99%

A Retrospective Study of Methylprednisolone Mini-Pulse Therapy Combined with Narrow-Band UVB in Non-Segmental Vitiligo

et al. 2015

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Background: Systemic corticosteroids have been used to arrest the progression of vitiligo. However, side effects have been a constant issue. Objective: We evaluated the clinical efficacy and side effect of oral methylprednisolone (MPD) mini-pulse therapy combined with narrow-band UVB (NBUVB) for adults with non-segmental vitiligo retrospectively. Methods: 32 patients with extensive and/or spreading vitiligo received 0.5 mg/kg MPD on 2 consecutive days per week with NBUVB therapy for at least 3 months. Results: All of the 32 patients (100%) showed progression arrest within 12 weeks. Nineteen out of 32 patients (59.4%) presented repigmentation on more than 25% of lesions. Thirteen patients (40.6%) achieved satisfactory repigmentation in more than 50% of lesions. Only 2 patients discontinued the medication due to gastrointestinal trouble. Conclusion: Oral MPD mini-pulse therapy combined with NBUVB appears effective in arresting vitiligo progression and rapidly inducing repigmentation with minimal side effects.

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Vitiligo: A comprehensive overview

Cited by 152 publications

References 176 publications

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

Assessment of Dietary Supplementation in the Treatment of Vitiligo

A Retrospective Study of Methylprednisolone Mini-Pulse Therapy Combined with Narrow-Band UVB in Non-Segmental Vitiligo

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