Vitiligo and Other Diseases: Coexistence or True Association?

Abstract

In the past, several authors described an association of vitiligo with autoimmune disorders and the presence of different tissue autoantibodies. A review of the literature showed large differences in the results. Therefore, 321 patients with vitiligo (male/female ratio 114/207) were examined to see whether the frequencies of associated diseases and phenomena (i.e. Koebner phenomenon, canities praecox, halo nevi, poliosis circumscripta), the number of pigmented lesions and the presence of autoantibodies are of significance in order to support (a) a subentity of childhood vitiligo and (b) whether there is a true predisposition or association of autoimmune or other diseases in this group of patients. The data confirm earlier results of a prevalence of thyroid disease and the presence of thyroid antibodies, whereas other diseases are a random event. 6.2% of the patients had congenital nevi compared with 2.8% in a normal healthy population. Based on the results of this study and the significant higher risk for development of melanomas in this patient group, an annual checkup is recommended.

Audiological and Electrophysiological Changes in Patients with Vitiligo

“…Various recent clinical and animal experimental studies [3][4][5] support the premise that the pathogenetic mechanisms of Vitiligo could be systemic events as vitiligo is associated with ocular [6][7][8][9] and auditory abnormalities and other autoimmune disorders [2,3,9,10]. There have been few studies in India on the ocular and otic abnormalities and the presence of other autoimmune disorders in association with vitiligo [11][12][13].…”

Acute Segmental Poliosis Immediately After Surgical Trauma: Case Report

“…Poliozisli hastaların büyük çoğunluğunu çocukların ve segmental vitiligolu hastaların oluşturduğu göste-rilmiştir. 17,18 Segmental vitiligolu 208 hasta üzerinde yapılan bir çalışmada 101 (%49)'inde poliozis saptanmış ve en sık kaş tutulumu olduğu görülmüş-tür. 19 Yine kirpik tutulumu da bu hastalarda nadiren vitiligoyla birlikte izole bir bulgu olarak bildirilirken, trigeminal dermatomun en çok tutulan dermatom olduğu rapor edilmiştir.…”

A Case of Poliosis Caused by Halo Nevus

“…Poliozisli olguların büyük çoğunluğunu çocuk hastaların oluşturduğu gözlemlenmiştir. 10,11 Bizim olgumuzun dermatolojik muayenesinde ve Wood lambası bakısında vücudun herhangi bir yerinde vitiligoyu düşündürecek depigmente lezyona rastlanmamıştır.…”