Vitiligo and pregnancy: How do each affect the other?

Abdelhafez, Mohsen M A; Ahmed, Karim A. M.; Pang, Nicholas Tze Ping; Baharuddin, Dg Marshita Pg; Than, Win Win; Kadir, Fairrul; Jeffree, Mohammad Saffree; Hayati, Firdaus

doi:10.1016/j.amsu.2021.102833

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…6 In a study from Singapore regarding vitiligo and pregnancy, in six months postdelivery assessment, about (36%) of patients reported disease worsening in vitiligo. 7 Wood's lamp examination is useful in pigmentary disorders like melasma, vitiligo, ash leaf macules of tuberous sclerosis. In vitiligo, it helps in marking early lesions so that effective targeted phototherapy can be given.…”

Section: Discussionmentioning

confidence: 99%

Repigmentation of vitiligo universalis masquerading as pseudo-melasma

Muna,

Shanmugam

2023

Int J Res Dermatol

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Vitiligo is a common depigmentation disorder that affects the melanocytes. We present a case of middle-aged female with complaints of pigmented lesion over both cheeks. Clinical differentials of melasma, pregnancy induced hypertension (PIH) was considered but which on further evaluation turned out to be re-pigmentation in vitiligo universalis that had developed during her postpartum which masqueraded as melasma.

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Section: Discussionmentioning

confidence: 99%

Repigmentation of vitiligo universalis masquerading as pseudo-melasma

Muna,

Shanmugam

2023

Int J Res Dermatol

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Understanding the mechanism of disease of vitiligo and the impact on clinical management

McElroy,

Casquejo,

et al. 2024

Journal of Dermatology for Physician Assistants

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Vitiligo is a depigmenting skin condition that affects 0.5% to 2.0% of the global population and can significantly affect quality of life. Although vitiligo may be dismissed as cosmetic or untreatable, pathogenesis is driven by immunologic mechanisms that can be blocked with treatment, leading to skin repigmentation. The disease typically begins with genetic or environmental factors that induce skin cell stress, which initiates a cascade of immune events resulting in the recruitment of T cells to the skin and the destruction of melanocytes. Various treatment options exist that can block this autoimmune attack and allow repigmentation to occur over time. However, given the complexity of vitiligo pathogenesis, many patients do not fully understand their disease, how repigmentation can be achieved, or why repigmentation is a slow process that requires long-term treatment. Furthermore, dermatology health care providers may find it difficult to explain the underlying disease mechanism of vitiligo or answer patient questions about treatment. Better education about vitiligo and repigmentation mechanisms is crucial for successful disease management. This review aims to summarize what is known about vitiligo pathogenesis and current treatment options so dermatology health care providers can help patients manage their vitiligo with realistic expectations. Supplemental materials include additional information that can be shared with patients.

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An Overview of the Biological Complexity of Vitiligo

Matarrese,

Puglisi,

Mattia

et al. 2024

Oxidative Medicine and Cellular Longevity

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Vitiligo is a skin disease that affects all ethnicities and genders and is characterized by the loss of pigment essentially due to the selective loss of melanocytes. Although it is generally considered a systemic disease associated with polymorphisms in genes involved in the immune response, vitiligo is also considered an oxidative imbalance‐associated disease. It represents a multifactorial pathology in which some genetic predisposition and epigenetic factors coupled with some critical biochemical and molecular pathways could play a pivotal role. The aim of this work was thus to review some of the fine cellular mechanisms involved in the etiopathogenesis of vitiligo, mainly focusing on the nonimmunological ones, extensively highlighted elsewhere. We took into consideration, in addition to oxidative stress, both the cause and the hallmark of the pathology, some less investigated aspects such as the role of epigenetic factors, e.g., microRNAs, of receptors of catecholamines, and the more recently recognized role of the mitochondria. Sex differences associated with vitiligo have also been investigated starting from sex hormones and the receptors through which they exert their influence. From literature analysis, a picture seems to emerge in which vitiligo can be considered not just a melanocyte‐affecting disease but a systemic pathology that compromises the homeostasis of a complex tissue such as the skin, in which different cell types reside playing multifaceted physiological roles for the entire organism. The exact sequence of cellular and subcellular events associated with vitiligo is still a matter of debate. However, the knowledge of the individual biological factors implicated in vitiligo could help physicians to highlight useful innovative markers of progression and provide, in the long run, new targets for more tailored treatments based on individual manifestations of the disease.

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Vitiligo and pregnancy: How do each affect the other?

Cited by 3 publications

References 9 publications

Repigmentation of vitiligo universalis masquerading as pseudo-melasma

Repigmentation of vitiligo universalis masquerading as pseudo-melasma

Understanding the mechanism of disease of vitiligo and the impact on clinical management

An Overview of the Biological Complexity of Vitiligo

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