Vitiligo and the HLA System

Metzker, Aryeh; Zamir, R.; Gazit, Ephraim; David, Maria Priscilla; Feuerman, Eleasar J.

doi:10.1159/000250480

Cited by 44 publications

(35 citation statements)

References 4 publications

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“…The relative risk (RR) for HLA B13 was 9.3 (p = 0. (X)2); for young Yemenites, there was a significant increase in HLA BW35 (R R = 13.89) [13], A study in the Netherlands has reported an increase in HLA A2, DRW6. DRW52 and DQW1 [ 14].…”

Section: Introductionmentioning

confidence: 96%

Histocompatibility Antigens in Vitiligo: Hamburg Study on 102 Patients from Northern Germany

Schallreuter¹,

Levenig²,

Kühnl

et al. 1993

Dermatology

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One-hundred and two patients from the area of Hamburg, Germany, with vitiligo (photo-skin types II and III, Fitzpatrick classification, 1979), were examined for a possible association of the human lymphocyte antigen (HLA) complex with this disease. Antisera panels for the detection of 75 HLA antigens were utilized for this HLA typing (WHO Bulletin, 1988). The results were compared with 400 unrelated age- and sex-matched controls with photo-skin types II and III from the same geographical area. Nine of 76 vitiligo patients showed a significantly increased expression of the rare antigen HLA DRW 12 (p_c = 0.000708), and 65/102 patients showed a marginally significant increased frequency of HLA A2 (p_c = 0.04850) compared with controls. For HLA BW60 (40), a significant increase in frequency was shown only in the adult vitiligo group (p_c = 0.0126). A ‘preventive’ antigen for the manifestation of vitiligo has not been identified in this study. A comparative analysis of all published data on the possible association of HLA with vitiligo does not support a definitive linkage to the MHC so far.

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Section: Introductionmentioning

confidence: 96%

Histocompatibility Antigens in Vitiligo: Hamburg Study on 102 Patients from Northern Germany

Schallreuter¹,

Levenig²,

Kühnl

et al. 1993

Dermatology

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“…Furthermore, the study of major histocompatibility complex polymorphism in vitiligo has already shown some promising results [12][13][14][15][16][17][18][19], Reports have documented an increased expression of HLA-DR4 in white [13] and black [15] American patients with vitiligo and HLA-DQw3 in black American vitiligo patients [15]. Metzker et al [16] noted an increased fre quency of HLA-B13 in young Jewish Moroccan and HLABw35 in young Yemenite vitiligo patients, while Poloy et al [18] found an increased presence of HLA-DR 1 in Cau casian Hungarians. To our knowledge, this is the first pub lished report looking at HLA phenotypes, familial inci dence and clinical distribution of vitiligo in the Northern Italian population.…”

Section: Introductionmentioning

confidence: 99%

Vitiligo Is Associated with a Significant Increase in HLA-A30, Cw6 and DQw3 and a Decrease in C4AQ0 in Northern Italian Patients

et al. 1992

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HLA polymorphisms of class I (HLA-A, B, C) of class II (HLA-DR, DQ) and of class III (C4A, C4B, BF) were investigated in 93 Northern Italian patients affected with vitiligo and in 388 controls. Vitiligo patients had significant increases in HLA-A30 (corrected p, p_c = 0.0144), Cw6 (p_c = 0.0189), DQw3 (p_c < 0.0003) and a significant decrease in C4AQ0 (p_c = 0.003). Nonfamilial vitiligo is marked by increases in HLA-A30 and DQw3. Extensive vitiligo is marked by increases in HLA-A30 and Cw6. These findings suggest that imraunogenetic mechanisms may be responsible for vitiligo and that unique HLA phenotypes may influence the expression of vitiligo in this population.

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“…The association of several HLA class I antigens with susceptibility for development of vitiligo has been extensively investigated in the different ethnic population, showing the increased frequencies of the occurrence of HLA-A2, -A30, -A31, -B13, -B46, -Cw4, -Cw6, etc. in patients with vitiligo [1][2][3][4]. On the other hand, by using linkage disequilibrium analysis in familial vitiligo, it has been demonstrated that a major determinant of vitiligo might be located in HLA [5].…”

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confidence: 99%