Vitiligo: Auto‐immunity and immune responses

Sehgal, Virendra; Srivastava, Govind

doi:10.1111/j.1365-4632.2005.02651.x

Cited by 30 publications

(23 citation statements)

References 144 publications

(231 reference statements)

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“…[789101112] As vitiligo usually occurs before the development of thyroid disease, it may be advantageous to screen thyroid function and autoimmune antibodies in all vitiligo patients. [13] Anti-thyroid antibodies are the secondary immune response markers which can reflect the damage to thyroid function. What is more, positivity for thyroid globulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) are important diagnostic criteria for AITD, most of which are polyclonal IgG antibodies.…”

Section: Introductionmentioning

confidence: 99%

Clinical analysis of thyroglobulin antibody and thyroid peroxidase antibody and their association with vitiligo

et al. 2014

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Background:Recently, the abnormal presence of thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) has been reported in vitiligo patients, but presence of TG-Ab and TPO-Ab in patients of different ages and gender, and its association with vitiligo and thyroid autoimmunity has rarely been reported. The aim of our research was to determine whether vitiligo was associated with thyroid autoimmunity and figure out its relationship with age and gender.Materials and Methods:We analyzed TG-Ab, TPO-Ab in age and gender matched 87 vitiligo patients and 90 healthy controls, the patients of vitiligo who were positive for the presence of TG-Ab and TPO-Ab were followed up to confirm autoimmune thyroid disease subsequently.Results:Results showed that the frequencies of TG-Ab (23.0%, 20/87) positivity and TPO-AB (24.1%, 21/87) in vitiligo patients were significantly higher than that in healthy controls (P < 0.05). Moreover, The positivity for of TG-Ab and TPO-Ab was higher in 11-20-year age group and 21-40-year age group than that in age matched healthy controls. We found female patients with vitiligo had higher positive frequencies of TG-Ab and TPO-Ab than healthy female controls. (34.1% vs. 8.8% and 34.1% vs. 11.1%, P = 0.000 and P = 0.011). When 20 patients with TG-Ab and TPO-Ab positivity were followed up for three monthes, 14 of them (70%) were diagnosed as having autoimmune thyroid disease compared with age-matched healthy controls (16.7%, χ2 = 5.4, P = 0.02).Conclusion:TG-Ab and TPO-Ab are likely to be found in female teenagers with vitiligo, and are relevant with respect to subsequent development autoimmune thyroid disease.

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Section: Introductionmentioning

confidence: 99%

Clinical analysis of thyroglobulin antibody and thyroid peroxidase antibody and their association with vitiligo

et al. 2014

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“…It is well known that vitiligo is associated with various autoimmune disorders and autoimmunity is supposed to play a role in its pathogenesis [19]. The frequency of autoimmune thyroid disease is increased among vitiligo patients and their first-degree relatives [20] and the frequency of vitiligo is higher among patients with Hashimoto's thyroiditis and Graves' disease [21].…”

Section: Discussionmentioning

confidence: 99%

Vitiligo in a Patient Treated with Interferon Alpha-2a for Behçet’s Disease

Güney

Akçali

Akçay

et al. 2012

Case Reports in Medicine

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Behçet's disease (BD) and vitiligo are diseases of unknown etiology. Interferon (IFN) alpha therapy is commonly used in Behçet uveitis. Interferon treatment in various diseases have also been observed causing certain autoimmune diseases such as vitiligo because of its immunomodulatory activity. The association between IFN therapy and vitiligo has been reported in the literature. We report a 21-year-old man with BD in whom vitiligo occurred during IFN treatment. To the best of our knowledge, this is the first reported case of such an association.

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“…It remains to be determined whether these antibodies and cells are the cause or the consequence of melanocyte cell death. More importantly, familial vitiligo, which accounts for a third of patients with vitiligo, is associated with other autoimmune/autoinflammatory diseases, including diabetes, autoimmune thyroid disease, rheumatoid arthritis, Addison's disease and systemic lupus erythematosus [79]. The locus for this familial vitiligo was recently identified on chromosome 17, where the gene coding for NALP1 (NLRP1) is positioned [80].…”

Section: Nalp1 and Vitiligomentioning

confidence: 99%

Insight into the inflammasome and caspase-activating mechanisms

Gaide¹,

Hoffman²

2008

Expert Review of Clinical Immunology

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Inflammasomes are recently discovered molecular complexes that can sense danger signals and specifically activate caspase-1 and -5 and proinflammatory cytokines (IL-1beta and IL-18). Upon signaling, the inflammasome complex forms around a NOD-like receptor family member that serves both as a danger sensor and as a recruiting platform. The number of known triggers that stimulate inflammasomes is rapidly rising, ranging from genetic mutations to microbial products, gout crystals, ultraviolet light and adjuvant chemicals. As a result of this surprising diversity, the inflammasome may have a significant impact on most medical fields. A good understanding of the molecular mechanisms underlying its activation/regulation is essential today, as several therapeutic and diagnostic tools have already reached the bedside, and more are sure to come.

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Vitiligo: Auto‐immunity and immune responses

Cited by 30 publications

References 144 publications

Clinical analysis of thyroglobulin antibody and thyroid peroxidase antibody and their association with vitiligo

Clinical analysis of thyroglobulin antibody and thyroid peroxidase antibody and their association with vitiligo

Vitiligo in a Patient Treated with Interferon Alpha-2a for Behçet’s Disease

Insight into the inflammasome and caspase-activating mechanisms

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