Vitiligo following COVID-19: A case report and review of pathophysiology

Schmidt, Alexandra; Rubin, Arnold D.; Milgraum, David; Wassef, Cindy

doi:10.1016/j.jdcr.2022.01.030

Cited by 16 publications

(14 citation statements)

References 9 publications

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“…In a study conducted by Salama and colleagues, they reported that the prevalence of vitiligo in COVID-19 patients was significantly higher than in the control group. In addition, they found that the mean age of COVID-19 patients with vitiligo was significantly lower than those without vitiligo [ 19 ]. This finding is consistent with other studies that have reported a higher prevalence of COVID-19 in younger patients with vitiligo [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Post-COVID pigment loss: the connection between vitiligo and the pandemic

Dhaiban,

Abduljabbar Alfadagh,

Jasim

2024

pdia

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Introduction Vitiligo is an acquired disorder characterized by the progressive loss of functional melanocytes, resulting in depigmented macules and patches on the skin. It affects a significant portion of the world’s population, with no specific gender or geographic predilection. Aim To explore the current understanding of the association between vitiligo and COVID-19. Material and methods This is a cross-sectional comparative research of 90 vitiligo patients, separated into two groups: those with COVID-19 confirmed by PCR and those without, gathered in 2018 before the pandemic. Al-Sadar teaching hospital in Al Basra gathered data from March 2021 to May 2022. Vitiligo patients with other infections were excluded. Wood’s test was used to confirm vitiligo (VASI score). Age, gender, site of vitiligo, number of lesions, and family history were gathered for all patients in both groups. Results Patients with vitiligo and COVID-19 had mild (70.27%), moderate (18.92%), and severe (10.81%) infections. Significant differences were found in age, duration, and VASI score, with younger patients and lower VASI scores in the Vitiligo + COVID-19 group. Females (60.6%) were more affected, and lower limbs (66.7%) were the most common site of vitiligo lesions in COVID-19 patients. Conclusions 70.27% of vitiligo and COVID-19 patients had mild infections, 18.92% had moderate infections, and 10.81% had severe infections. Patients with both disorders were younger, had shorter vitiligo durations, and lower VASI scores than those with just one. Females were more likely to have both disorders, and lower limb vitiligo was more prevalent. Family history did not affect either group.

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Section: Discussionmentioning

confidence: 99%

Post-COVID pigment loss: the connection between vitiligo and the pandemic

Dhaiban,

Abduljabbar Alfadagh,

Jasim

2024

pdia

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“…The same process is supposed to take place after COVID-19 vaccination, where cross-reactivity to viral antigens has been advocated as a plausible vitiligo etiopathogenic mechanism. 3,4 Notably, COVID-19 infection has been linked to immune dysregulation, causing an immune shift towards cytotoxic CD8 + T lymphocytes, similar to the immune dysregulation described Publisher's note: all claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.…”

Section: Discussionmentioning

confidence: 99%

Childhood vitiligo developing after COVID-19 infection

et al. 2023

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Coronavirus disease 2019 (COVID-19) and COVID-19 vaccinations have been linked to immune cutaneous manifestations, mostly presenting similar clinical pictures.1 Among immune skin reactions associated with COVID-19 vaccines, hypopigmentations and vitiligo have been extensively reported.2 Conversely, reports of vitiligo following COVID-19 itself are scarce up to date, completely lacking in children.3,4 Herein we present a case of childhood vitiligo developing shortly after COVID-19 infection.

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“…To the best of our knowledge, only 16 additional cases linking vitiligo to COVID-19 have been reported in the literature and are summarized in Table 1 , including the ones occurring as a new onset and recrudescence after vaccination and manifestations of the disease in the course of COVID-19 infection [ 1 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Our search revealed 7 male patients affected versus 11 female patients whose age at presentation ranged from 13 to 86 years (mean age 50.625 ± 17.421).…”

Section: Review Of Literaturementioning

confidence: 99%

Vitiligo-like Lesions and COVID-19: Case Report and Review of Vaccination- and Infection-Associated Vitiligo

et al. 2022

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Several cutaneous manifestations in patients undergoing COVID-19 vaccination have been described in the literature. Herein, we presented a case of new-onset vitiligo that occurred after the second dose of the Comirnaty vaccine. An updated literature search revealed the occurrence of a total of 16 cases, including new-onset or worsening of preexisting vitiligo. Given the autoimmune pathogenesis of the disease, we reviewed and discussed the potential role of the vaccine prophylaxis as a trigger for the development of such hypopigmented skin lesions.

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Vitiligo following COVID-19: A case report and review of pathophysiology

Cited by 16 publications

References 9 publications

Post-COVID pigment loss: the connection between vitiligo and the pandemic

Post-COVID pigment loss: the connection between vitiligo and the pandemic

Childhood vitiligo developing after COVID-19 infection

Vitiligo-like Lesions and COVID-19: Case Report and Review of Vaccination- and Infection-Associated Vitiligo

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