Vitiligo in Children: A Review of Conventional Treatments

Gianfaldoni, Serena; Wollina, Uwe; Tchernev, Georgi; Lotti, Jacopo; França, Katlein; Lotti, Torello

doi:10.3889/oamjms.2018.054

Cited by 15 publications

(12 citation statements)

References 24 publications

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“…Topical corticosteroids are are considered the first line treatment for limited vitiligo, <20% of body surface area 6 , explaining its use by 92% (n=111) of patients in this study. Several studies have shown that topical corticosteroids is moderately effective to induce repigmentation of vitiligo+24.…”

Section: Discussionmentioning

confidence: 90%

“…Despite vitiligo was reported to affects both genders in equal proportions in adults and sometimes in children 7 , childhood vitiligo tends to affect females more frequently than males. 6 A study by El-Husseiny R et al 2020 8 involving 483 child with vitiligo observed that females were affected in 59.1% (n=130) of patients. In addition, similar results were observed by Shajil et al 2006 9 and Nunes & Esser 2011 10 .…”

Section: Discussionmentioning

confidence: 98%

“…Systemic immuomodulators and immunosuppressives are used for rapidly progressive disease to achieve rapid control, particularly systemic corticosteroids; however, their use should be limited to a short duration to avoid undesirable side effect. 6…”

Section: Introductionmentioning

confidence: 99%

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Childhood Vitiligo: A Retrospective Clinico-Epidemiological Study

Ahmed

Mohammed

et al. 2020

Preprint

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Background: Vitiligo is an acquired depigmentary disorder of the skin, mucous membrane and hair follicle resulting from selective destruction of melanocytes. Aims of Study: Identify the clinico-epidemiological characteristics of childhood vitiligo. Patients and Methods: A retrospective study carried out at the dermato-venereology clinic of Salah Al-Din Hospital. A total of 120 vitiligo patients, all younger than 17 years old, were enrolled. Results: Among included patients, (40%) were male and (60%) were female (M:F=2:3). The mean age of onset was (11.5 SD 6.4 years) with (60.8%) of patients were (11-17) years old, (25%) were (6-11) years and (14.2%) were (0-5) years old. Majority of patients were from urban area (87.5%). Generalized types of vitiligo account for (56.7%) besides (22.5%), (17.5%) and (3.3%) represented focal, acrafacial and segmental vitiligo, respectively. Only (8.3%) have nail changes, presented as longitudinal ridging followed by leukonychia. Family history was positive in (37.5%) of vitiligo patients. Treatment used for vitiligo were topical corticosteroids (92.5%), topical calcineurin inhibitors (55%), NB-UVB (84.2%), and systemic steroids (30.8%). Conclusions: Majority of childhood vitiligo develops after puberty and predominantly affects female. Generalized vitiligo is the most frequent type. Atopic dermatitis is the most common associated disease.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 98%

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Childhood Vitiligo: A Retrospective Clinico-Epidemiological Study

Ahmed

Mohammed

et al. 2020

Preprint

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“…Topical vitamin D analogues are thought to have an impact by making an immunomodulation and melanogenesis stimulation through vitamin D receptors (34)(35)(36)(37). A study on the subject has reported success in 10 cases out of 18 children (31).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Demographic Characteristics of Children with Vitiligo: Retrospective Analysis of 105 Cases

Akbaş¹,

Kılınç²,

Aktaş³

2019

Turkish Journal of Pediatric Disease

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Objective: Vitiligo is a disease for which the cause is not clearly known public but is common and is characterised by depigmented macules. It's incidence rate ranges between 0.1-11%. Incidence among children is not known clearly but it has been reported that in half of the cases lesions start before the age of, and in 25% they start before 10-14 years and it has different characteristics than that in adults. The aim of this study is to define the clinical and demographic characteristics of childhood vitiligo, identify the accompanying diseases and the treatment options that are provided. Material and Methods: The files of 105 paediatric patients diagnosed with vitiligo in our hospital's dermatology department during the 2011-2018 period have been retrospectively examined. Age, gender, starting age, disease duration, lesion area, vitiligo type, family vitiligo history, blood tests and accompanying diseases have been recorded. Vitiligo types have been divided into 2 main groups, namely segmental and no segmental. Cases with generalized (vulgar), focal, acral, acrofacial vitiligo have been included in non-segmental vitiligo cases. Results: 44.76% of the patients are female. The average age was 10.98±4.77 years, the average age when the condition started was 9.63±4.53 years and average duration of the disease was 19.19±19,60 months (1.59 years). Number of cases in 0-2 age group was 7 (6.66%), 3-5 age group was 10 (9.52%), 6-11 age group was 32 (30.47%), 12-18 age group was 56 (53.33%). In terms of duration of the disease, 0-2 months included 12 patients (11.42%), 3-6 months included 11 patients (10.47%), 7 months to 1 year included 9 patients (8.57%), and over a year included 73 patients (6.52%). With regards to the types of vitiligo, 6.66% (n=7) had segmental vitiligo, 92.38% (n=97) had non-segmental vitiligo, 0.95% (n=1) had mixed type vitiligo. 53.60% (n=52) of non-segmental vitiligo was focal vitiligo, 31.95% (n=31) was vitiligo vulgaris 7.21% (n=7) was acrofacial and 7.21% (n=7) was acral type. In terms of focal vitiligo 40.38% (n=21) had cheek involvement, 23.07% (n=12) periorbital involvement, 11.53% (n=6) perioral involvement, 7.69% (n=4) genital involvement and five cases (9.61%) had multiple involvements. In 30.4% of the cases (n=32), one or more coexisting disease has been observed to exist. Treatment options differed by age. While topical steroids and calcineurin inhibitors have been preferred in younger ages and in limited lesions, while in older ages and in more spread lesions phototherapy and systemic treatment methods have been practised. Conclusion: This study is addressing the clinical and demographic characteristics of children with vitiligo as well as the practised treatment options. In contrast to other studies, this study has concluded more incidences among males. Regarding people in the early stages of vitiligo and in lesions localised in head-neck area, micro-therapy has been observed to be effective and calcineurin inhibitors have hastened repigmentation.

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“…The repigmentation in vitiligo is believed to be linked to a synergistic effect of all the antioxidant action of these herbal bio-actives. The availability of any new treatment that can reduce the use of UVB from high to low, and still be efficacious, is of immense benefit to both patients and treating physicians [21], [22], [23], [24], [25], [26], [27], [28], [29].…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Vitiligo Vietnamese Patients with VitilinexÂ® Herbal Bio-Actives in Combination with Phototherapy

Van¹,

Minh²,

Huu³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND:Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented skin and phototherapy are current treatment options for vitiligo although phototherapy remains the treatment of choice. There is no documented evidence that herbal bio-active products may also be effective treatment options for vitiligo.AIM:This study aimed to investigate the efficacy and safety of Vitilinex® (herbal bio- actives) alone and in combination with UVB narrowband (311 nm) phototherapy, in the treatment of localised stable or active forms of vitiligo.MATERIAL AND METHODS:Sixty two subjects with mean age 34.5 years (range: 18-58 years) with mild to moderate vitiligo, consisting of 36 females and 26 males were randomly divided into three treatment groups – Group A (13 females, 10 males) treated with Vitilinex® alone; Group B (12 females, 11 males) were treated with Vitilinex® in combination with narrowband UVB (311 nm) phototherapy for 15 seconds, using a handheld lamp and Group C (8 females, 8 males) were treated with nbUVB (311 nm) phototherapy alone, for 15 seconds over a 12-week period.RESULTS:In Group A, 9 patients (39%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 2 patients experiencing total repigmentation. 6 patients (26%) had marked improvement with a repigmentation rate between 50-75% while 5 patients (22%) showed a moderate response between 25-50% re-pigmentation rate. 3 patients (13%) had minimal or no improvement. In Group B, 16 patients (69.5%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 12 patients experiencing total re-pigmentation. 4 patients (17.5 %) achieved a marked improvement with a re-pigmentation rate between 50-75%; 2 patients (8.7%) showed a moderate response with a re-pigmentation rate between 25-50%. 1 (4.3%) patient had minimal or no improvement. In Group C, 6 patients (37.5%) achieved a re-pigmentation rate higher than 75%, with 2 patients experiencing total re-pigmentation. 4 patients (25%) achieved marked improvement with a re-pigmentation rate between 50-75% while 3 patients (18.75%) had a re-pigmentation rate between 25-50%. 3 patients (18.75%) had minimal or no improvement.CONCLUSION:Vitilinex® herbal bio-actives in combination with nbUVB is a more effective treatment option for vitiligo with 87% of the patients achieving a re-pigmentation rate higher than 50%, compared to Vitilinex® alone (65%) or nbUVB alone (62.5%).

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Vitiligo in Children: A Review of Conventional Treatments

Abstract: Vitiligo is an important skin disease of childhood, which may lead to deep psychological trauma, resulting in a poor quality of life and low self-esteem. The Authors discuss a short review of the more conventional therapies available for the treatment of vitiligo in children.

Cited by 15 publications

References 24 publications

Childhood Vitiligo: A Retrospective Clinico-Epidemiological Study

Childhood Vitiligo: A Retrospective Clinico-Epidemiological Study

Clinical and Demographic Characteristics of Children with Vitiligo: Retrospective Analysis of 105 Cases

Successful Treatment of Vitiligo Vietnamese Patients with VitilinexÂ® Herbal Bio-Actives in Combination with Phototherapy

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