Vitiligo: Treatment by dermabrasion and epithelial sheet grafting

Kahn, A; Cohen, Myles J.

doi:10.1016/0190-9622(95)91287-8

Cited by 78 publications

(62 citation statements)

References 6 publications

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“…All five patients treated by grafts harvested with a Zimmer dermatome repigmented completely during the followup period of 3.5-35.5 months. Although no scarring was observed, all the patients developed milia on the recipient site [56]. In another study by Kahn and Cohen, good to excellent repigmentation was observed in 88% of the 17 procedures performed on 12 patients using meshed grafts without scarring [38].…”

Section: Split-skin Graftingmentioning

confidence: 99%

Surgical management of vitiligo

Mulekar¹

2010

Expert Review of Dermatology

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Vitiligo is a common condition characterized by hypopigmented and/or depigmented spots on the skin, affecting approximately 1-2% of the world population. Until approximately 30 years ago, it was exclusively treated by medical therapies. The most commonly used medical therapies include topical steroids, calcineurin inhibitors and phototherapy. Lesions on the face and neck respond the best to medical therapies, followed by lesions on the proximal extremities and trunk, while those distributed over acral parts of extremities and nonhairy areas, such as the wrist, feet and male genitals, respond poorly. Surgical methods complement medical therapies by providing melanocytes to these refractory lesions, and are indicated for unilateral segmental and clinically stable bilateral vitiligo, refractory to medical treatment. Tissue-grafting methods include minigrafting or punch grafting, epidermal grafting and split thickness grafting. These methods use full-thickness punch grafts, roof of epidermal blisters and shave biopsy samples, respectively, as the source of melanocytes. Cellular grafting includes noncultured and cultured melanocytes/keratinocytes suspensions obtained from trypsinizing the shaved skin biopsy sample as a source of melanocytes. Recent advances over the years have enabled dermatologists to treat extensive areas located on any anatomic site in a single operative session by surgical intervention. The purpose of this review is to describe the selection criteria for the surgical treatment, their utility and limitations in the various types of vitiligo.

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Section: Split-skin Graftingmentioning

confidence: 99%

Surgical management of vitiligo

Mulekar¹

2010

Expert Review of Dermatology

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“…Treatment of large areas may require 1Á5-5 h and is best performed in a hospital setting under general anaesthesia. 21,22 Kahn and Cohen 21 performed 17 procedures on 12 patients with stable vitiligo. The repigmentation was considered good to excellent in 88% (15) of the operations.…”

Section: Split-thickness Skin Grafts or Thin Dermoepidermal Graftsmentioning

confidence: 99%

“…Grafts can be harvested using a Humby's knife, a Silver's skin grafting knife or a Zimmer â electric dermatome (Zimmer, Warsaw, IN, U.S.A.). 21,22 The recipient area may be prepared by using a motorized dermabrader with a diamond fraise wheel or by laser ablation. Small procedures may be performed in an office setting with local anaesthesia (Fig.…”

Section: Split-thickness Skin Grafts or Thin Dermoepidermal Graftsmentioning

confidence: 99%

Surgical interventions for vitiligo: an evidence-based review

Mulekar¹,

Isedeh

2013

Br J Dermatol

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SummaryBackground Vitiligo is a disfiguring disease, characterized frequently by the presence of de-pigmented macules and/or patches. Traditional therapies are essentially medical and are most preferred by dermatologists. Surgical therapies, however, are amongst the most effective interventions for vitiligo but are limited by their invasive nature, as well as the training and expertise needed to perform specific procedures. Objectives To assess the evidence for the effectiveness, safety and applicability of the various surgical methods in the treatment of vitiligo. Methods For this systematic review of vitiligo surgical therapies, our searches included: PubMed, MEDLINE and Cochrane databases. Results We reviewed research studies reporting on split thickness skin grafts (STSG), punch/mini-graft, blister roof grafting, cultured and non-cultured cellular transplantation (MKTP). While all methods vary in their repigmentation outcomes, STSG is found to have the highest repigmentation success rate. Overall, post-operative complications included milia, scarring, cobblestone appearance or hyperpigmentation of treated areas. Conclusion This review highlights the need for more randomized controlled trials in this field, underpinned by a more standardized objective approach to the assessment of repigmentation following surgical interventions.

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“…(2) Bhel in 1964, was first to report the use of thin thresh skin graft to treat vitiligenous patch. (3) Khan et al, (4) used a modification of this technique, where they used ultrathin split thickness grafts (<0.08-0.15mm). Olsan & Juhlin, (5) employed this technique to transplant melanocytes to the vitiligenous area.…”

Section: Introductionmentioning

confidence: 99%

Ultra Thin Epidermal Skin Grafting for Stable Viti Ligo : A Cost Effective and Cosmetically Satisfying Treatment Option

Pinjala¹,

T²,

Ch³

et al. 2015

jemds

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Ultrathin epidermal skin grafting is the simplest aesthetic procedure for stable vitiligo. Various surgical procedures such as miniature Punch Grafting, Suction blister grafting, Mash technique etc are available for covering stable vitiligenous depigmented area. This article reviews about the relatively easy and new technique in treating stable Vitiligo. Ultra thin epidermal skin grafting involves transfer of a very thin layer of skin including epidermis to achieve transfer of melanocytes from donor graft to the underlying dermabraded vitiligenous recipient area.

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Vitiligo: Treatment by dermabrasion and epithelial sheet grafting

Cited by 78 publications

References 6 publications

Surgical management of vitiligo

Surgical management of vitiligo

Surgical interventions for vitiligo: an evidence-based review

Ultra Thin Epidermal Skin Grafting for Stable Viti Ligo : A Cost Effective and Cosmetically Satisfying Treatment Option

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