Vitiligo: Treatment by dermabrasion and epithelial sheet grafting—a preliminary report

Kahn, A; Cohen, Myles J.; Kaplan, Leo; Highton, Anita

doi:10.1016/0190-9622(93)70089-c

Cited by 30 publications

(16 citation statements)

References 5 publications

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“…In spite of excellent repigmentation (Behl and Bhatia, 1973) with minimal or no scarring (Kahn et al., 1993), this method has not gained popularity so far. Grafts are harvested at a depth of 0.1–0.3 mm, placed directly on recipient abraded areas next to each other and secured with surgical dressings under mild pressure for one week.…”

Section: Surgical Methodsmentioning

confidence: 99%

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Update on skin repigmentation therapies in vitiligo

Falabella

Barona

2009

Pigment Cell Melanoma Res

137

121

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SummaryTreatment for vitiligo is difficult and prolonged. Nevertheless, at present considerable knowledge accumulated during several decades on the pathogenic mechanisms, revealed important clues for designing new strategies to improve vitiligo depigmentation. With available medical therapies, high repigmentation percentages mostly on facial and neck lesions are achieved, although they are less effective on trunk and limbs and poor on the acral parts of the extremities. Narrow band UVB and psoralens and UVA are the two most important treatments for generalized vitiligo affecting more than 10-20% of the cutaneous surface, and topical corticosteroids, or calcineurin inhibitors are the most valuable treatments for localized vitiligo. Persistence of achieved regimentation is variable and an undefined percentage of patients may have variable recurrence.When vitiligo becomes refractory, surgical methods may improve depigmentation as effectively as with medical therapy; in segmental (unilateral) or long standing, non-segmental (bilateral) stable vitiligo, repigmentation with surgical methods is usually permanent.

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Section: Surgical Methodsmentioning

confidence: 99%

“…Acral regions as the dorsum of hands and fingers also respond with success. (Kahn and Cohen, 1995; Kahn et al., 1993). After 17 procedures in 12 patients with stable vitiligo, good to excellent repigmentation was observed in 88% procedures (Kahn and Cohen, 1998).…”

Section: Surgical Methodsmentioning

confidence: 99%

Update on skin repigmentation therapies in vitiligo

Falabella

Barona

2009

Pigment Cell Melanoma Res

137

121

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“…Behl in 1973 demonstrated repigmentation of vitiligo patch with autologous thin Thiersch's grafts of 0.1‐0.2 mm thickness. Ultra‐thin skin grafts (1993) of 0.08‐0.15 mm of thickness have now become the preferred tissue source for melanocytes. A donor skin of 10%‐20% larger than the recipient area is harvested using skin harvesting knife.…”

Section: Tissue Graftsmentioning

confidence: 99%

Vitiligo surgery: A journey from tissues via cells to the stems!

Afra

Parsad

2018

Experimental Dermatology

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Depigmented patches in vitiligo, a common dermatosis, cause a great psychological distress to the patients. Hence, apart from halting the disease process, the strategies to impart normal skin colour to these white patches carry an important role in the management of vitiligo. Surgical procedures are often required for stable vitiligo lesions not responding to medical therapies. It involves “shuffling” of melanocytes from the pigmented skin to the depigmented areas. During the last fifty years, the vitiligo surgery has evolved from tissue transplantation via cellular transplantation to reach a stage where the use of stem cells or immunomodulatory cells is contemplating. We would like to depict this wonderful journey of vitiligo surgery through this viewpoint.

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“…Autologous epidermal grafting is popular in the treatment of certain types of vitiligo. 1–6 Autologous epidermal grafting was performed in 22 vitiligo patients who were followed up for 5–27 months. 7 Many of these patients acquired and maintained the pigmentation after the graft; 5 however, the pigmentation on the recipient site was often mottled.…”

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confidence: 99%