Vitreoretinal Lymphoma

Sobolewska, Bianka; Zaguia, Fatma; Goldstein, Debra A.; Smith, Justine R.; Fend, Falko; Mochizuki, Manabu; Zierhut, Manfred

doi:10.3390/cancers13163921

Cited by 34 publications

(30 citation statements)

References 153 publications

(244 reference statements)

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“…CSF evaluation for the disease, an MRI of the entire spinal axis for tumor characterization, and a slit-lamp ophthalmologic examination are vital to rule out vitreoretinal involvement as it could harbor lymphoma and be a site for recurrence [ 9 ]. Moreover, before starting chemotherapy, cardiac evaluation and a central venous access line are needed in anticipation of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Concurrent Herpes Simplex Virus Type 1 and Cytomegalovirus Encephalitis Complicated by Primary Central Nervous System Lymphoma as an Initial Presentation of Acquired Immunodeficiency Syndrome

Findakly¹

2021

Cureus

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Primary central nervous system lymphoma (PCNSL) is an uncommon brain tumor with a puzzling diagnosis. It has an incidence of seven cases per 100,000,000 people in the United States, which is further lower in immunocompromised patients. Cytomegalovirus (CMV) is a common cause of various malignancies, notably Burkitt’s lymphoma, nasopharyngeal carcinoma, Hodgkin’s lymphomas, and non-Hodgkin’s lymphomas (NHL) including PCNSL. Cases with PCNSL can vary in presentation with either focal or non-focal manifestations progressively worsening over a period that could last up to a few months. In this report, we discuss the case of a 39-year-old woman with a past medical history of bipolar disorder who presented with PCNSL as the initial presentation of acquired immunodeficiency syndrome (AIDS). This case report emphasizes the importance of a multidisciplinary team (MDT) approach for the interpretation as well as for correlating the laboratory and imaging results with clinical findings given the challenging diagnosis, to choose an appropriate management approach that is tailored to the patient's presentation.

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Section: Discussionmentioning

confidence: 99%

An Unusual Case of Concurrent Herpes Simplex Virus Type 1 and Cytomegalovirus Encephalitis Complicated by Primary Central Nervous System Lymphoma as an Initial Presentation of Acquired Immunodeficiency Syndrome

Findakly¹

2021

Cureus

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“…Lymphoma can also metastasize to the uvea, retina, and vitreous, particularly from the testes, cutaneous T-cell lymphoma, or the nasopharynx, all of which have been well documented. Patients with known systemic lymphoma complaining of floaters or decreased vision should have an ophthalmologic consultation to exclude this possibility (27)(28)(29). PVRL, on the other hand, is a subset of primary central nervous system lymphoma (PCNSL) and is most often of the diffuse large B-cell lymphoma type.…”

Section: Pvrlmentioning

confidence: 99%

Neuro-ophthalmic manifestations of cancer: a narrative review

Janetos¹,

Volpe²,

Simon³

2022

Chin Clin Oncol

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Background and Objective: Neuro-ophthalmic manifestations of cancer are vast and early recognition of a serious ocular condition due to either cancer or its therapy is important for both vision preservation as well as providing valuable treatment and prognostic information regarding the underlying malignancy. This review focuses on direct and indirect effects of cancer on the eye and its adnexa, hematologic malignancy, complications of traditional and novel oncologic therapies, and paraneoplastic syndromes as they relate to the eye as these disorders can lead to potentially devastating or irreversible vision loss.Methods: PubMed was searched primarily for the following topics: optic nerve infiltration, primary vitreoretinal lymphoma (PVRL), ocular paraneoplastic disorders, and ophthalmic complications of cancer therapeutics. Literature was selected based on historical significance and landmark studies (e.g., Cross et al.series of paraneoplastic optic neuritis patients; Chan's textbook on primary intraocular lymphoma) as well as publications published after 2000. References from select studies were additionally included. Given the sparsity of literature on many subjects, most publications were included during this time frame in our review.

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“…Vitreoretinal lymphoma is an ocular cancer that has both high morbidity and high mortality. 1 In the majority of cases, the cancer is a diffuse large B-cell non-Hodgkin lymphoma based in vitreous, retina and/or optic nerve; although other subtypes of B-cell and T-cell lymphoma are described, these are exceptional. 2 Patients with vitreoretinal lymphoma experience a range of visual symptoms, and floaters and blurred vision are common complaints.…”

Section: Introductionmentioning

confidence: 99%

“…The cancer frequently masquerades as intraocular inflammatory disease—termed uveitis—and patients may initially be treated with corticosteroid and other immunomodulatory drugs. 1 The gold standard for diagnosis is cytology and flow cytometry, performed on ocular samples that are obtained by vitrectomy. 8 However, the diagnosis often remains elusive as cells are scant and fragile, and lymphotoxic immunomodulatory therapy may compound this problem.…”

Section: Introductionmentioning

confidence: 99%

The International Vitreoretinal B-Cell Lymphoma Registry: a protocol paper

et al. 2022

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IntroductionVitreoretinal lymphoma is a rare ocular cancer with high morbidity and mortality despite treatment. Diagnosis by cytopathology is often delayed, and various molecular and image-based investigations have been developed. Diverse treatments are used, but there is a limited medical evidence to differentiate their effectiveness. We designed an international registry that would collect diagnostic, treatment and outcomes data, to establish new evidence for the management of this cancer.Methods and analysisThe International Vitreoretinal B-Cell Lymphoma Registry will accrue data retrospectively for individuals aged 18 years or older, diagnosed with new or recurrent vitreoretinal B-cell lymphoma on or after 1 January 2020. A steering committee of subspecialised ophthalmologists identified 20 key clinical data items that describe patient demographics, tissue involvements, diagnostic testing, ocular and systemic treatments and treatment complications, and visual acuity and survival outcomes. Customised software was designed to permit collection of these data across a single baseline and multiple follow-up forms. The platform collects data without identifiers and at 3 month reporting intervals. Outcomes of the project will include: (1) descriptions of clinical presentations, and diagnostic and therapeutic preferences; (2) associations between clinical presentations, and diagnostics and treatments, and between diagnostics and treatments (assessed by ORs with 95% CIs); and (3) estimations of rates of vision loss, and progression-free and overall survival (assessed by Kaplan-Meier estimates).Ethics and disseminationThe registry has received Australia-wide approval by a national human research ethics committee. Sites located outside Australia are required to seek local human research ethics review. Results generated through the registry will be disseminated primarily by peer-reviewed publications that are expected to inform clinical practice, as well as educational materials.

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Vitreoretinal Lymphoma

Cited by 34 publications

References 153 publications

An Unusual Case of Concurrent Herpes Simplex Virus Type 1 and Cytomegalovirus Encephalitis Complicated by Primary Central Nervous System Lymphoma as an Initial Presentation of Acquired Immunodeficiency Syndrome

An Unusual Case of Concurrent Herpes Simplex Virus Type 1 and Cytomegalovirus Encephalitis Complicated by Primary Central Nervous System Lymphoma as an Initial Presentation of Acquired Immunodeficiency Syndrome

Neuro-ophthalmic manifestations of cancer: a narrative review

The International Vitreoretinal B-Cell Lymphoma Registry: a protocol paper

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