Vitreoretinal lymphoma following primary testicular lymphoma: Report of two cases and review of the literature

Abstract

Purpose To report two cases of vitreoretinal lymphoma that developed following primary testicular lymphoma and review the literature. Observations Two men, one age 66 and the other age 77, both with a history of diffuse large B-cell testicular lymphoma, diagnosed one and three years previously, respectively, presented with vitritis and yellow-white subretinal infiltrates. Diagnostic vitrectomy in both cases revealed diffuse large B-cell lymphoma. Systemic work up in both cases showed no evidence of disease relapse elsewhere. Each were treated with intravitreal methotrexate injections. Conclusions Vitreoretinal lymphoma can occur following primary testicular lymphoma, and may mimic primary vitreoretinal lymphoma. Monitoring of patients with a history of testicular lymphoma with regular dilated fundus examinations should be considered.

Relapse of Ocular Lymphoma following Primary Testicular Diffuse Large B-cell Lymphoma

“…The histological confirmation of DLBCL with cytology and immunohistochemistry was performed using an incisional biopsy sample of the uveal tissue. Cases of ocular involvement following primary testicular lymphoma have previously been reported internationally [4][5][6][7]9]. All these cases presented as vitreoretinal lymphoma and were confirmed using a diagnostic vitrectomy specimen of the vitreous fluid; the subtype of the lymphoma was DLBCL.…”

“…In this case, the patient had undergone CNS prophylaxis; nevertheless, recurrences in the CNS involving the brain and eye occurred two years after achieving the first and second complete remissions, respectively. Most previously reported cases have also demonstrated later involvement of the eye after CNS prophylaxis or treatment for CNS recurrence that arose from 1 year up to 11 years following initial diagnosis of PTL [4,6,7,9]. The CNS is the most common site of PTL relapse [1].…”