Vitroceramic interface deposited on titanium substrate by pulsed laser deposition method

Voicu, Georgeta; Miu, Dana; Dogaru, Ionuţ; Jinga, Sorin‐Ion; Busuioc, Cristina

doi:10.1016/j.ijpharm.2015.10.083

Cited by 15 publications

(8 citation statements)

References 43 publications

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“…In conclusion, the two oxide powders that will be integrated in the polymeric fibers are in the form of partially crystallized materials, which are suitable for various applications in the medical field, since they contain a large amount of vitreous phase, as well as certain beneficial crystalline phases. According to the scientific literature, the amorphous matrix increases the bioactivity through the labile structure [ 1 , 16 , 36 ], while the crystalline compounds seem to express their influence at the level of mechanical properties, cellular proliferation/differentiation favoring or osteogenesis stimulation [ 37 , 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Composite Fiber Networks Based on Polycaprolactone and Bioactive Glass-Ceramics for Tissue Engineering Applications

et al. 2020

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In this work, composite fibers connected in three-dimensional porous scaffolds were fabricated by electrospinning, starting from polycaprolactone and inorganic powders synthesized by the sol-gel method. The aim was to obtain materials dedicated to the field of bone regeneration, with controllable properties of bioresorbability and bioactivity. The employed powders were nanometric and of a glass-ceramic type, a fact that constitutes the premise of a potential attachment to living tissue in the physiological environment. The morphological characterization performed on the composite materials validated both the fibrous character and oxide powder distribution within the polymer matrix. Regarding the biological evaluation, the period of immersion in simulated body fluid led to the initiation of polymer degradation and a slight mineralization of the embedded particles, while the osteoblast cells cultured in the presence of these scaffolds revealed a spatial distribution at different depths and a primary networking tendency, based on the composites’ geometrical and dimensional features.

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Section: Resultsmentioning

confidence: 99%

Composite Fiber Networks Based on Polycaprolactone and Bioactive Glass-Ceramics for Tissue Engineering Applications

et al. 2020

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“…A vitreous matrix which encapsulates specific crystalline phases, easily attackable when placed in contact with the physiological fluids and prone to apatite formation, represents a material with bioactive potential. The identified crystalline silicate compounds (Ca 2 SiO 4 , Ca 1.8 Sr 0.2 SiO 4 ) also play important roles in emphasizing the biocompatible and bioactive character, while SiO 2 can act as a reinforcing agent, improving the mechanical properties [41].…”

Section: Interfaces Characterizationmentioning

confidence: 99%

“…[37][38][39][40]. Pulsed laser deposition (PLD) is such an alternative, involving the ablation of one or more targets with a pulsed laser beam, followed by material transfer via plasma at the surface of a support; stoichiometry preservation and lack of contamination are the most representative assets [41]. Spin coating (SC) is another option for growing one-dimensional structures from a precursor solution that is rotated at high speed on the surface of a substrate; experimental simplicity and thickness control constitute its gains [42].…”

Section: Introductionmentioning

confidence: 99%

“…Our research group reported on several complex oxide systems, which were processed by sol-gel, spin coating and pulsed laser deposition as bioactive and biocompatible coatings [6,8,16,41,42], leading to considerable expertise in the field. In this work, novel compositions including Mg or Sr were tested in the form of thin films for providing suitable materials to coat the bioinert ceramic or metallic bone implants, ensure a biologically active interface and subsequently triggering speeded and superior osseointegration of them within the afflicted body.…”

Section: Introductionmentioning

confidence: 99%

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Development of New Mg- or Sr-Containing Bioactive Interfaces to Stimulate Osseointegration of Metallic Implants

et al. 2020

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The purpose of this study resides in the design and deposition of several types of bioactive interfaces with complex composition, targeting a superior osseointegration of bone implants. The experimental approach is framed by two oxide systems, SiO2‒CaO‒P2O5‒ZnO‒MgO and SiO2‒CaO‒P2O5‒ZnO‒SrO, while the percentage values were established as optimised solutions for ensuring wear resistance, bioactivity and beneficial effects on cell metabolism and reproduction. Moreover, two methods dedicated to fils growth (pulsed laser deposition and spin coating) were explored as potential variants for coating the bioinert materials and providing a transitional anchoring layer between the artificial substitute and host tissue. The obtained layers were evaluated as vitroceramic in nature, nanostructured in morphology and bioactive in relation to the physiological environment. The response of human fetal osteoblasts placed in contact with the new engineered surfaces was characterized by a significant proliferation from 1 to 4 days, which validates their suitability for hard tissue applications.

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“…Thus, the quest is to develop a composite material with all the mechanical properties of titanium alloys, encapsulated in a leak-proof ceramic, that can be biologically preactivated prior to implant [20,21].With the advent of laser-based additive manufacturing [22], such composite material is now a reality. In this case, a commercial or custom-made ceramic target is ablated by a pulsed laser, a plume of plasma is generated and directed towards the metallic substrate, upon which it settles, forming a thin layer that physically binds to the support [23,24]. Our research group has already reported the growth of nanostructured akermanite-based thin films by pulsed laser deposition, with good biocompatibility and bioactivity [25].…”

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confidence: 99%

Development of Vitroceramic Coatings and Analysis of Their Suitability for Biomedical Applications

et al. 2019

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Within the field of tissue engineering, thin films have been studied to improve implant fixation of metallic or ceramic materials in bone, connective tissue, oral mucosa or skin. In this context, to enhance their suitability as implantable devices, titanium-based substrates received a superficial vitroceramic coating by means of laser ablation. Further, this study describes the details of fabrication and corresponding tests in order to demonstrate the bioactivity and biocompatibility of the newly engineered surfaces. Thus, the metallic supports were covered with a complex material composed of SiO 2 , P 2 O 5 , CaO, MgO, ZnO and CaF 2 , in the form of thin layers via a physical deposition techniques, namely pulsed laser deposition. The resulting products were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning and transmission electron microscopy coupled with energy dispersive X-ray spectroscopy, selected area electron diffraction, and electron energy loss spectroscopy. It was found that a higher substrate temperature and a lower working pressure lead to the highest quality film. Finally, the samples biocompatibility was assessed and they were found to be bioactive after simulated body fluid soaking and biocompatible through the MTT cell viability test.Coatings 2019, 9, 671 2 of 13 drawbacks, like fibrous tissue growth, slow osseointegration and reduced close contact with the host bone, were noticed upon wider use of titanium alloy implants [19]. Thus, the quest is to develop a composite material with all the mechanical properties of titanium alloys, encapsulated in a leak-proof ceramic, that can be biologically preactivated prior to implant [20,21].With the advent of laser-based additive manufacturing [22], such composite material is now a reality. In this case, a commercial or custom-made ceramic target is ablated by a pulsed laser, a plume of plasma is generated and directed towards the metallic substrate, upon which it settles, forming a thin layer that physically binds to the support [23,24]. Our research group has already reported the growth of nanostructured akermanite-based thin films by pulsed laser deposition, with good biocompatibility and bioactivity [25]. Since both the target characteristics and processing conditions strongly influence the properties of the final coatings [26], more studies are necessary in order to elucidate which are the driven factors and optimized set of parameters.Thus, the aim of this work is to produce a material that is durable and readily implantable. A type of vitroceramic coatings on titanium substrates were developed, characterized and then immersed in simulated biological fluid to be coated with a hydroxyapatite-like layer and demonstrate its bioactivity [27,28]. Further biological tests indicated that, indeed, this combination of materials resulted in an artifact that responds well to the in vitro cell proliferation. Author Contributions: Conceptualization, S.-I.J. and C.B.; methodology, C.B. and D.M.; validation, S.-I.J.; investigation...

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Vitroceramic interface deposited on titanium substrate by pulsed laser deposition method

Cited by 15 publications

References 43 publications

Composite Fiber Networks Based on Polycaprolactone and Bioactive Glass-Ceramics for Tissue Engineering Applications

Composite Fiber Networks Based on Polycaprolactone and Bioactive Glass-Ceramics for Tissue Engineering Applications

Development of New Mg- or Sr-Containing Bioactive Interfaces to Stimulate Osseointegration of Metallic Implants

Development of Vitroceramic Coatings and Analysis of Their Suitability for Biomedical Applications

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