2023
DOI: 10.3389/fimmu.2023.1078005
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Vitronectin promotes immunothrombotic dysregulation in the venular microvasculature

Abstract: Microvascular immunothrombotic dysregulation is a critical process in the pathogenesis of severe systemic inflammatory diseases. The mechanisms controlling immunothrombosis in inflamed microvessels, however, remain poorly understood. Here, we report that under systemic inflammatory conditions the matricellular glycoproteinvitronectin (VN) establishes an intravascular scaffold, supporting interactions of aggregating platelets with immune cells and the venular endothelium. Blockade of the VN receptor glycoprotei… Show more

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“…Another enigma involves high shear and the accumulation of an intense network of vitronectin in the microvasculature during systemic inflammation; this promotes immunothrombosis by permitting the interaction of platelets, immune cells, and endothelial cells in an αIIbβ3-dependent manner. 100 Does its absence have clinical consequences in GT? A more visible challenge involves persistent GI bleeding in GT patients especially when linked to angiodysplasia.…”
Section: Inflammation and Gastrointestinal Bleedingmentioning
confidence: 99%
“…Another enigma involves high shear and the accumulation of an intense network of vitronectin in the microvasculature during systemic inflammation; this promotes immunothrombosis by permitting the interaction of platelets, immune cells, and endothelial cells in an αIIbβ3-dependent manner. 100 Does its absence have clinical consequences in GT? A more visible challenge involves persistent GI bleeding in GT patients especially when linked to angiodysplasia.…”
Section: Inflammation and Gastrointestinal Bleedingmentioning
confidence: 99%