Vitronectin promotes insulin resistance in trophoblast cells by activating JNK in gestational diabetes mellitus
Yuejun Ju,
Ting Shen,
Zhanhong Guo
et al.
Abstract:Gestational diabetes mellitus (GDM) is a common disorder in the clinic, which may lead to severe detrimental outcomes both for mothers and infants. However, the underlying mechanisms for GDM are still not clear. In the present study, we performed label‐free proteomics using placentas from GDM patients and normal controls. Vitronectin caused our attention among differentially expressed proteins due to its potential role in the pathological progression of GDM. Vitronectin was increased in the placentas of GDM pa… Show more
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