Vocal Cord Paralysis and its Etiologies: A Prospective Study

Toutounchi, Seyed Javad Seyed; Eydi, Mahmood; Golzari, Samad Ej; Ghaffari, Mehdi; Parvizian, Nashmil

doi:10.5681/jcvtr.2014.009

Cited by 35 publications

(14 citation statements)

References 28 publications

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“…Trauma and malignancy are two well understood causes of VCP that account for 28.89% and 31.11% cases, respectively [ 3 ]. A large portion of cases (29.8–65.7%) are reported as idiopathic in etiology [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Unilateral paralysis is more commonly left-sided, given the extended journey of the left recurrent laryngeal nerve and a resulting increase in opportunities for injuries to occur [ 2 ]. VCP is traditionally considered to have three primary etiologies: trauma, malignancy, and idiopathic causes [ 3 ]. The relative percentages of these etiologies have changed over time.…”

Section: Introductionmentioning

confidence: 99%

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An 18-Year-Old Female Experiences Unilateral Vocal Cord Paralysis during Mild COVID-19 Infection

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Wright

Underbrink

2022

Case Reports in Otolaryngology

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The COVID-19 pandemic has shown with certainty that SARS-CoV-2 can cause a variety of clinical findings, with some of the most notable being lasting chemosensory changes. Severe infections with SARS-CoV-2 can also lead to a variety of complications. For example, vocal cord paralysis can be caused by trauma sustained during intubation, which is a necessary procedure for many severe cases. Rarely, SARS-CoV-2 related vocal cord paralysis has occurred outside the context of intubation. These cases contribute to an emerging assortment of evidence supporting the neuropathic capacity of SARS-CoV-2. This report documents a case of COVID-19 related vocal cord paralysis in an 18-year-old female. The patient had a significant history of muscle tension dysphonia, chronic laryngitis, and vocal cord nodules. The patient developed vocal cord paralysis concurrently with the onset of mild viral symptoms and was never intubated or hospitalized. Based on the onset of symptoms and other causes being excluded with CT, a diagnosis of COVID-19-related vocal cord paralysis was performed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An 18-Year-Old Female Experiences Unilateral Vocal Cord Paralysis during Mild COVID-19 Infection

Coggins

Wright

Underbrink

2022

Case Reports in Otolaryngology

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“…Here, as an extension to that, the mass effect from the acute expanding pseudoaneurysm has compressed the recurrent laryngeal nerve as it has passed under the arch of the aorta, leading to the left vocal cord palsy and the clinical presentation of a hoarse voice. The majority of causes of vocal cord paralysis are encompassable in three groups: firstly, tumor related; secondly, surgical or traumatic; and finally idiopathic [6] . Phonation changes are the overwhelming majority of as the reason for referral and further investigation in patients with vocal cord paralysis [6] .…”

Section: Discussionmentioning

confidence: 99%

“…The majority of causes of vocal cord paralysis are encompassable in three groups: firstly, tumor related; secondly, surgical or traumatic; and finally idiopathic [6] . Phonation changes are the overwhelming majority of as the reason for referral and further investigation in patients with vocal cord paralysis [6] . As recommended, vocal cord paralysis is indicative of an underlying cause and these patients need an integrated investigation and management approach [6] .…”

Section: Discussionmentioning

confidence: 99%

Bronchial artery pseudoaneurysm presenting with hoarseness: Diagnosis and endovascular management

Viiala

Catt

et al. 2022

Radiology Case Reports

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“…Vocal fold (VF) paralysis and atrophy occur commonly via damage of the recurrent laryngeal nerve due to carcinoma or trauma . The recurrent laryngeal nerve is recognized to play an essential role in phonation through innervation of the intrinsic laryngeal muscle .…”

Section: Introductionmentioning

confidence: 99%

Regeneration of Paralyzed Vocal Fold by the Injection of Plasmid DNA Complex-Loaded Hydrogel Bulking Agent

Kim

Park

Choi

et al. 2019

ACS Biomater. Sci. Eng.

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Various growth factor delivery systems were used in the treatment of glottal insufficiency; however, relatively little attention has been paid to a gene delivery system for aspects of active vocal fold (VF) regeneration. Herein, we present a plasmid DNA (pDNA; bFGF gene encoding) complex-loaded alginate (ALG)/hyaluronic acid (HA) mixture hydrogel dispersed with polycaprolactone (PCL) microspheres that can enhance simultaneous regeneration of VF muscle and lamina propria, as well as have a bulking effect on atrophied VF. We have demonstrated long-term efficacy of bFGF synthesized from pDNA complex-transfected cells in vitro. PCL microspheres–dispersed ALG/HA hydrogel (with or without pDNA complex loading) are injected into rabbit VFs with recurrent laryngeal nerve denervation. The PCL microspheres dispersed in the hydrogel bulking agents remain stable at the applied site, leading to constant medialization of the paralyzed VF without significant initial volume loss even after 24 weeks. A regenerative effect for collagen deposition and HA synthesis around the injected site, which are major components of VF tissue, is well confirmed in the pDNA-complex-loaded hydrogel group. Moreover, the compensation of atrophied VFs also leads to the contact of bilateral VF and the remarkable recovery of voice function in the pDNA-complex-loaded group. Based on the results, pDNA (bFGF encoding) complex-loaded hydrogel dispersed with PCL microspheres may be employed as a bioactive bulking agent for the treatment of glottal insufficiency.

show abstract

Vocal Cord Paralysis and its Etiologies: A Prospective Study

Cited by 35 publications

References 28 publications

An 18-Year-Old Female Experiences Unilateral Vocal Cord Paralysis during Mild COVID-19 Infection

An 18-Year-Old Female Experiences Unilateral Vocal Cord Paralysis during Mild COVID-19 Infection

Bronchial artery pseudoaneurysm presenting with hoarseness: Diagnosis and endovascular management

Regeneration of Paralyzed Vocal Fold by the Injection of Plasmid DNA Complex-Loaded Hydrogel Bulking Agent

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