2016
DOI: 10.1016/j.bbr.2016.03.006
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Vocal training, levodopa, and environment effects on ultrasonic vocalizations in a rat neurotoxin model of Parkinson disease

Abstract: Levodopa does not improve dysarthria in patients with Parkinson Disease (PD), although vocal exercise therapy, such as “LSVT/LOUD®”, does improve vocal communication. Most patients receive vocal exercise therapy while concurrently being treated with levodopa, although the interaction between levodopa and vocal exercise therapy on communication in PD is relatively unknown. Further, carryover of vocal exercise therapy to novel situations is critical for successful outcomes, but the influence of novel situations … Show more

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Cited by 22 publications
(23 citation statements)
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“…DJ1 −/− animals also show increases in maximum and average call duration compared to WT animals. Decreases in call duration have previously been reported to correlate with losses in striatal dopamine following 6-hydroxydopamine infusions [36]. Consistent with this report, DJ1 −/− rats do not show loss of TH-immunoreactivity within the striatum through 8 mo of age, despite a significant loss of nigrostriatal dopamine neurons [10].…”
Section: Discussionsupporting
confidence: 85%
“…DJ1 −/− animals also show increases in maximum and average call duration compared to WT animals. Decreases in call duration have previously been reported to correlate with losses in striatal dopamine following 6-hydroxydopamine infusions [36]. Consistent with this report, DJ1 −/− rats do not show loss of TH-immunoreactivity within the striatum through 8 mo of age, despite a significant loss of nigrostriatal dopamine neurons [10].…”
Section: Discussionsupporting
confidence: 85%
“…Changes in vocalizations in animal models of PD have been demonstrated in several model species. Common findings in rodents with parkinsonism induced by neurotoxin or transgenesis are reduced number of calls, reduced intensity of calls, and reduced call-complexity [24, 41, 42], most of which are improved with behavioral therapy (vocal exercise) [25, 43] but not with levodopa [44]. Studies in common marmosets with neurotoxin-induced parkinsonism have only reported a reduced number of vocalizations, without performing any further acoustic analyses [45, 46, 47, 48, 49].…”
Section: Discussionmentioning
confidence: 99%
“…A high pass filter was used to eliminate noise below 25-kHz. Calls were then categorized (simple, harmonic, frequency modulated (FM)) by independent raters masked to condition (see [30,58,59] for details). Because few-to-no harmonic calls existed for both genotypes over time, statistical analysis is focused on simple and FM call types.…”
Section: Ultrasonic Vocalizationmentioning
confidence: 99%