he lipodystrophies are rare disorders characterized by selective but variable loss of adipose tissue. They are a group of acquired or genetic disorders which are characterised by selective fat loss, ranging from partial to generated. 1,2 Metabolic complications, such as insulin resistance, diabetes mellitus, hypertriglyceridemia, and fatty liver, increase in severity with the extent of fat loss. 3 Barraquer-Simons syndrome-now called Acquired Partial Lipodystrophy (APL)-was first defined as lipodystrophic disorder about a century ago. Only 250 cases had been reported in the literature since then. It is characterized by the loss of subcutaneous tissue, limited to upper part of the body, with the face, neck, arms, thorax, and upper abdomen. 4 Women are more often affected than men. 5 Different from other types of lipodystrophies, insulin resistance and hypertriglyceridemia are less severe. Although patients