Vogt-Koyanagi-Harada Disease

Cunningham, Emmett T.; Rathinam, Sivakumar R.; Tuğal-Tutkun, İlknur; Muccioli, Cristina; Zierhut, Manfred

doi:10.3109/09273948.2014.939530

Cited by 33 publications

(30 citation statements)

References 38 publications

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“…These diseases can be excluded on the basis of clinical manifestations, disease course, systemic medical workup, and ophthalmic imaging findings. [9,10,12,13] There was a significant improvement in BCVA and OCT findings in this case following the administration of high-dose intravenous corticosteroid. During the rapid tapering of the corticosteroid due to systemic complications, fellow eye involvement appeared clinically.…”

Section: Discussionmentioning

confidence: 55%

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Vogt-Koyanagi-Harada with Unilateral Clinical Presentation: A Case Report

Hosseini

Dourandish

Mazouchi

2020

JOVR

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Purpose: To report a case of acute Vogt-Koyanagi-Harada (VKH) disease with unilateral clinical manifestations followed by late fellow eye involvement. Case Report: This case report reviews the 12-month follow-up observation of a 44-year old woman who presented to the emergency department with unilateral progressive and painless visual blurring. Ophthalmoscopic findings, best-corrected visual acuity (BCVA), fluorescein angiography (FAG), enhanced-depth optical coherence tomography (EDIOCT), indocyanine green angiography, and response to treatment were evaluated. Her BCVA was 20/50 (logMAR: 0.4) in the right eye and 20/20 (logMAR: 0) in the left eye. Eye examination revealed optic disc swelling and multiple serous retinal detachments in the right eye and a normal left eye. She had headache, dysacusia, and mild hearing problems. Her past ocular and drug histories were unremarkable. Retinal imaging revealed characteristic features of VKH in the right eye. All laboratory testing results were inconclusive. VA and OCT findings significantly improved following the treatment with methylprednisolone 1 g/day continued by tapering dose of oral prednisolone. Two months after the presentation and during prednisolone tapering, VA of the left eye decreased and fundus examination revealed multiple serous retinal detachments in this eye. Conclusion: Ophthalmologists should recognize unilateral and asymmetrical VKH disease with subtle systemic involvement.

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Section: Discussionmentioning

confidence: 55%

“…Although according to the current revised diagnostic criteria, bilateral ocular involvement is necessary for the diagnosis of VKH, there are a few reports of unilateral or asymmetrical ocular involvement. [9,10,12,13] Our patient had clinical and paraclinical features compatible with VKH except for unilaterality at initial presentation.…”

Section: Discussionmentioning

confidence: 63%

Vogt-Koyanagi-Harada with Unilateral Clinical Presentation: A Case Report

Hosseini

Dourandish

Mazouchi

2020

JOVR

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“…A multimodal imaging approach utilizing FA, ICGA, and spectral domain-OCT is important in the differential diagnosis and follow-up of the disease. 12 CSCR is most commonly mistaken for the exudative retinal detachment seen in the acute phase of VKH. Findings that facilitate the diagnosis of CSCR are an absence of cells in the anterior chamber or vitreous and no sign of optic disc edema on examination; no choroidal thickening in USG; an absence of optic disc staining in late phases of FA; and observing multifocal hyperpermeability instead of diffuse hyperpermeability and the absence of hypofluorescence spots or optic disc staining on ICGA.9 Other findings that support CSCR diagnosis are the presence of dome-shaped serous detachment on OCT, subretinal precipitates, localized fibrin reaction, presence of RPE detachment and irregularities, no visible subretinal septa, fundus autofluorescence showing hypoautofluorescence in the area of subretinal fluid, and hyperautofluorescence corresponding with areas of leakage on FA.…”

Section: Discussionmentioning

confidence: 99%

Atypical Central Serous Chorioretinopathy

Cebeci¹,

Oray²,

Bayraktar³

et al. 2017

tjo

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Bullous central serous chorioretinopathy (CSCR) is a rare variant of CSCR characterized by severe serous retinal detachment which especially involves the inferior quadrants. Corticosteroid therapy administered for systemic or ocular misdiagnoses may induce and exacerbate CSCR. The purpose of this study was to report diagnosis and treatment results of an unusual case of bullous CSCR induced by systemic and periocular corticosteroid therapy received at another medical center due to a misdiagnosis of Vogt-Koyanagi-Harada disease.

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“…Current diagnostic criteria for VKH disease require the presence of bilateral ocular involvement; however, unilateral or delayed involvement of the fellow eye can occur in rare cases [ 8 ]. The diagnosis of VKH disease is essentially clinical and angiographic: exudative retinal detachment during the acute disease is very specific and FA typically reveals numerous punctate hyperfluorescent areas at the level of the retinal pigment epithelium in the early stage of the exam followed by pooling of dye in the subretinal space.…”

Section: Discussionmentioning

confidence: 99%

Unilateral Vogt-Koyanagi-Harada Disease: A Clinical Case Report

Neves

Cardoso

Almeida

et al. 2015

Case Rep Ophthalmol

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Purpose: To report a case of a 20-year-old female with decreased visual acuity (VA) in the left eye (LE). Methods: This is a retrospective and descriptive case report based on data from clinical records, patient observation and analysis of diagnostic tests. Results: A 20-year-old female presented with decreased VA in the LE for 3 days. Best-corrected visual acuity (BCVA) was 20/20 in the right eye (RE) and 20/40 in the LE. Pupillary function, intraocular pressure, results of external segment examinations and slit-lamp biomicroscopy were normal, bilaterally. RE fundoscopy was normal, and in the LE it revealed papillitis and posterior pole exudative retinal detachment. Optical coherence tomography (OCT) confirmed the macular serous retinal detachment and showed thickening of the posterior choroid also revealed by orbital ultrasound and magnetic resonance imaging (MRI). Fluorescein angiography showed angiographic features typical of Vogt-Koyanagi-Harada (VKH) disease: disseminated spotted choroidal hyperfluorescence and choroidal multifocal hypofluorescence, multifocal profuse leakage in the retina with pooling, serous retinal detachment and optic disc hyperfluorescence. Serological testing for the diagnosis of infectious pathologies was negative, and the review of systems was normal. The patient received systemic steroids and cyclosporine. LE BCVA improved up to 20/20 at 18 months after the diagnosis, with complete reabsorption of subretinal fluid and normal retinal and choroidal thickness by OCT. Conclusion: Despite the unilateral involvement, the clinical and angiographic features were typical of VKH disease, and ophthalmologists should be aware to recognize this rare clinical variant of the disease.

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Vogt-Koyanagi-Harada Disease

Cited by 33 publications

References 38 publications

Vogt-Koyanagi-Harada with Unilateral Clinical Presentation: A Case Report

Vogt-Koyanagi-Harada with Unilateral Clinical Presentation: A Case Report

Atypical Central Serous Chorioretinopathy

Unilateral Vogt-Koyanagi-Harada Disease: A Clinical Case Report

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