Vogt–Koyanagi–Harada patients show higher frequencies of circulating NKG2Dpos NK and NK T cells

Bonacini, Martina; Cimino, Luca; Simone, Luca De; Bolletta, Elena; Gozzi, Fabrizio; Soriano, Alessandra; Muratore, Francesco; Zerbini, Alessandro; Fontana, Luigi; Salvarani, Carlo; Croci, Stefania

doi:10.1111/cei.13563

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Although the exact pathogenesis is still uncertain, immunological and histopathological studies suggest that an innate immune response, mediated by CD4+ T-cells against melanin and melanocytes, plays a significant role in this disease. The autoimmune response is thought to have some stimulating factors such as genetic susceptibility and viral infection [104,105].…”

Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada Disease and COVID

Manni,

Saturno,

Accorinti

2023

JCM

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Vogt–Koyanagi–Harada (VKH) is a rare multisystem inflammatory disease affecting the eyes, ears, brain, skin, and hair. The Coronavirus Disease 2019 (COVID-19) is a new contagious infection that might trigger the onset of VKH disease, as previously proposed for other viruses. Moreover, after the mass vaccination against SARS-CoV-2 worldwide, cases of VKH disease associated with COVID-19 vaccination have been reported. We present an overview of VKH and a comprehensive literature revision of all the VKH cases described after COVID-19 infection and vaccination, adding our experience. No differences have been found considering epidemiology and clinical findings of the disease compared to those reported in the no-COVID era. All of the patients promptly responded to systemic and local corticosteroid therapy with a good final visual prognosis. Different possible pathogenetic mechanisms underlying the onset of VKH after COVID-19 vaccination are discussed, while the presence of the HLA DR4 antigen as a genetic predisposition for the onset of the disease after COVID-19 infection and vaccination is proposed. VKH disease is one of the most frequently reported uveitic entities after COVID-19 vaccination, but a good response to therapy should not discourage vaccination. Nevertheless, ophthalmologists should be alerted to the possibility of VKH occurrence or relapse after COVID-19 vaccination, especially in genetically predisposed subjects.

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Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada Disease and COVID

Manni,

Saturno,

Accorinti

2023

JCM

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“…[ 35 ] CD69 expression is upregulated during the inflammatory response in BD, AS, VKH, and other immune diseases. [ 36 , 37 ] Killer cell lectin-like receptor B1 (KLRB1; CD161) is expressed in NK cells, CD4 + and CD8 + T cell subsets, and NKT cells [ 38 ] and it is correlated with uveitis. [ 39 ] Bioinformatics analysis revealed that KLRB1 expression is also significantly upregulated in AS.…”

Section: Discussionmentioning

confidence: 99%

Analysis of differentially expressed genes in individuals with noninfectious uveitis based on data in the gene expression omnibus database

Zhang

Wang

et al. 2022

Medicine

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Noninfectious uveitis (NIU), an intraocular inflammation caused by immune-mediated reactions to eye antigens, is associated with systemic rheumatism and several autoimmune diseases. However, the mechanisms underlying the pathogenesis of uveitis are poorly understood. Therefore, we aimed to identify differentially expressed genes (DEGs) in individuals with NIU and to explore its etiologies using bioinformatics tools. GSE66936 and GSE18781 datasets from the gene expression omnibus (GEO) database were merged and analyzed. Functional enrichment analysis was performed, and protein-protein interaction (PPI) networks were constructed. A total of 89 DEGs were identified. Gene ontology (GO) enrichment analysis identified 21 enriched gene sets. Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis identified four core enriched pathways: antigen processing and expression signaling, natural killer (NK) cell-mediated cytotoxicity signaling, glutathione metabolic signal transduction, and arachidonic acid metabolism pathways. PPI network analysis revealed an active component-target network with 40 nodes and 132 edges, as well as several hub genes, including CD27, LTF, NCR3, SLC4A1, CD69, KLRB1, KIR2DL3, KIR3DL1 , and GZMK . The eight potential hub genes may be associated with the risk of developing NIU. NK cell-mediated cytotoxicity signaling might be the key molecular mechanism in the occurrence and development of NIU. Our study provided new insights on NIU, its genetics, molecular pathogenesis and new therapeutic targets.

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Developing the biomarker panels and drugs by proteomic analysis for autoimmune uveitis and posterior scleritis

Li,

An,

et al. 2024

iScience

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Vogt–Koyanagi–Harada patients show higher frequencies of circulating NKG2Dpos NK and NK T cells

Abstract: Vogt Koyanagi Harada patients show higher frequencies of NKG2Dpos NK and NKT cells. IL‐4, IL‐5, IL‐7, IL‐17 and PDGF‐bb are higher in plasma of Vogt Koyanagi Harada patients.

Cited by 3 publications

References 29 publications

Vogt-Koyanagi-Harada Disease and COVID

Vogt-Koyanagi-Harada Disease and COVID

Analysis of differentially expressed genes in individuals with noninfectious uveitis based on data in the gene expression omnibus database

Developing the biomarker panels and drugs by proteomic analysis for autoimmune uveitis and posterior scleritis

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