Vogt-Koyanagi-Harada Syndrome and Psoriasis

Psoriasis Occurring in Amelanotic Lesions

“…Our Case 1 and similar cases (1,4) in the literature in whom psoriatic lesions were prevalent in areas of vitiligo and cases (5,6) in whom psoriasis developed exclusively in amelanotic lesions of partial albinism and Vogt-Koyanagi-Harada syndrome suggest an interrelationship between psoriasis and amelanocytic lesions. We agree that two common dermatoses, vitiligo and psoriasis, could be coincidental and might not have pathogenetic links.…”

Vogt-Koyanagi-Harada Syndrome Associated with Psoriasis and Autoimmune Thyroid Disease

“…In most cases psoriasis preceded the onset of VKH by 1-25 years (2)(3)(4). Lesions were strictly restricted to the vitiliginous areas in one case (2). It is noteworthy that one patient did not present any dermatological sign of VKH (3).…”

“…An association between VKH and psoriasis has been reported in 4 cases in the literature (3 women out of 4, aged between 39 and 68 years) (2)(3)(4)(5). In most cases psoriasis preceded the onset of VKH by 1-25 years (2)(3)(4).…”

“…Nicolas Kluger 1 , Frédéric Mura 2 , Bernard Guillot 1 and Didier Bessis 1 Departments of 1 Dermatology, Hôpital Saint Eloi, and 2 Ophthalmology, Hôpital Gui-de-Chauliac, University of Montpellier I, CHU Montpellier, 80, Avenue Augustin Fliche, FR-34295 Montpellier Cedex 5, France. E-mail: nicolaskluger@yahoo.fr Accepted January 21, 2008.…”

Vogt‐Koyanagi‐Harada's Syndrome Associated with Hashimoto's Thyroiditis

“…Sugiura clarified that autoantibodies playa major role in melanocyte destruction via antibody-dependent cell mediated cytotoxicity (2). In a direct immunofluorescence test of a patient with VKH syndrome accompanied by psoriasis, Howsden et al demonstrated anti-IgG deposits in the intercellular spaces of epidermis and papillary dermis from vitiliginous skin, whereas those from the normal skin were negative (11). They stressed that the presence of IgG deposits in only the vitiliginous skin is noteworthy, considering the pathogenesis of VKH syndrome.…”