In this study, we tested a serial mediation model that examines psychological safety and work engagement as mediators in the relationship between humble leadership and employee voice with reference to social information processing theory. Data were collected from 442 white-collar employees of two government-owned companies located in a major city in Turkey. The results showed that both psychological safety and work engagement mediated the relationship between humble leadership and employee voice. This study determined that humble leadership had positive cognitive (psychological safety) and behavioral (work engagement and employee voice) outcomes during the times of the COVID-19 pandemic. The theoretical and practical implications of the results are also discussed.