Voice-Related Quality of Life in Patients with Multiple Sclerosis

Hamdan, Abdul‐Latif; Farhat, Sahar; Saadeh, Rami; El-Dahouk, Iyad; Sibai, Abla Mehio; Yamout, Bassem

doi:10.1155/2012/143813

Cited by 26 publications

(6 citation statements)

References 25 publications

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“…Comparing the results obtained in this study with other studies, it can be noticed that in all studies the mean values of VHI are relatively low, indicating only a slight degree of self-reported voice disorder. The results are for instance: 15.64 and 16.68 in studies conducted by Bauer et al (n=36 and n=38 respectively), (Bauer et al, 2013, Bauer et al, 2015 and 5.92 in a study by Hamdan et al (n=59) (Hamdan et al, 2012). The higher value obtained in our study, indicating worse voice quality reported by the patients may result from the fact that the study was conducted on a much bigger group of patients (n=107) with a formal neurological MS diagnosis.…”

Section: Discussionsupporting

confidence: 40%

Speech Pathology-Specific Questionnaire for Persons with Multiple Sclerosis (SMS): adaptation, validation and preliminary assessment of the diagnostic potential.

Morawska

Niebudek-Bogusz

Stasiołek

et al. 2021

Multiple Sclerosis and Related Disorders

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Speech and voice disorders are among the least well-described clinical manifestations of Multiple Sclerosis (MS) although their estimated prevalence reaches 40-50%. The aim of the present study was adaptation and validation of the Speech Pathology-Specific Questionnaire for Persons with Multiple Sclerosis (SMS) into the Polish language to be used as part of the diagnostic procedure to quantify important speech-related changes and to improve individual tailoring of therapeutic activities. Material and Methods:The study included a total number of 178 participants. The study group consisted of 107 patients diagnosed with Multiple Sclerosis, mean age 42.8±11.6 years and the Control Group were 71 healthy sex and age matched normophonic subjects, mean age 44.2±12.5 years with no neurological symptoms. Translated version of SMS was administered to all participants of the study. Voice Handicap Index (VHI) questionnaire was used for comparison purposes. Test-retest reproducibility, internal consistency, floor and ceiling effects, discriminant validity and construct validity of the Polish SMS were investigated. Preliminary assessment of diagnostic value of SMS was conducted on the basis of the results recorded in duration-related quartiles of the Study Group. Results: High value of Intraclass Correlation Coefficient (ICC= 0 .930) obtained for the test-retest indicates a good level of reproducibility of the Polish SMS. High Cronbach's alpha (α=0.94) proves the test's good internal consistency. There were no floor and ceiling effects for the SMS test score in the Study Group and they were negligible in the Control Group. A significant difference in mean SMS total scores between patients and controls (14.22 points vs. 6.06 points) shows discriminant validity of SMS. Similar differences were observed for all the subscales of the test (in t test: p<0.001). A statistically significant correlation was found for the SMS score and its all subscales, as well as between all the subscales of the test proving good construct validity of the test. Similarly, statistically significant correlations were observed for the total score of SMS and VHI (r=.817, p <0.001) as well as between the particular subscales of SMS test and the subscales of VHI. There was a statistically significant difference in the mean total score of SMS in the distinguished quartiles of the Study Group with the highest values (20 points) recorded in the group of patients suffering from MS for over 15 years. Conclusion: The psychometric properties of the Polish version of Speech Pathology-Specific Questionnaire indicate that it is a valid patient-reported outcome measure suitable for the assessment of speech-language pathology aspects on the population of Multiple Sclerosis patients and can be used as an complementary diagnostic tool in clinical practice.

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Section: Discussionsupporting

confidence: 40%

Speech Pathology-Specific Questionnaire for Persons with Multiple Sclerosis (SMS): adaptation, validation and preliminary assessment of the diagnostic potential.

Morawska

Niebudek-Bogusz

Stasiołek

et al. 2021

Multiple Sclerosis and Related Disorders

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“…A study of 59 participants with MS found no significant differences in the overall VHI score and subscores compared with the scores of healthy participants (VHI = 5.9, pVHI = 2.4, fVHI = 2.2, and eVHI = 1.4). 9 Only 8.7% of participants had serious vocal difficulties (VHI > 15). Contrary to that, the work by Natour et al analyzed VHI with 39 patients with MS, and a significant difference between patients with MS and healthy participants was noticed for both male and female participants (male VHI = 27.7 compared with VHI = 10.1 in the control group and female VHI = 19 compared with VHI = 11.4 in the control group).…”

Section: Discussionmentioning

confidence: 97%

“…The same conclusion was given in the study where only 12% of patients with MS described the difficulties of dysphonia. 9 On the other hand, the study of patients with MS performed by Natour showed significant differences in the self-assessment of vocal difficulties. 10 VHI was used, and a significant difference was observed between the total score and all subscores that were higher for patients with MS than the control group.…”

Section: Introductionmentioning

confidence: 99%

Comparing Voice Self-Assessment with Auditory Perceptual Analysis in Patients with Multiple Sclerosis

Bauer

Alerić

Jančić

2014

Int. Arch. Otorhinolaryngol.

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Introduction Disordered voice quality could be a symptom of multiple sclerosis (MS). The impact of MS on voice-related quality of life is still controversial. Objectives The aim of this study was to compare the results of voice self-assessment with the results of expert perceptual assessment in patients with MS. Methods The research included 38 patients with relapse-remitting MS (23 women and 15 men; ages 21 to 83, mean = 44). All participants filled out a Voice Handicap Index (VHI), and their voice sample was analyzed by speech and language professionals using the Grade Roughness Breathiness Asthenia Strain scale (GRBAS). Results The patients with MS had significantly higher VHI than control group participants (mean value 16.68 ± 16.2 compared with 5.29 ± 5.5, p = 0.0001). The study established a notable level of dysphonia in 55%, roughness and breathiness in 66%, asthenia in 34%, and strain in 55% of the vocal samples. A significant correlation was established between VHI and GRBAS scores (r = 0.3693, p = 0.0225), and VHI and asthenia and strain components (r = 0.4037 and 0.3775, p = 0.012 and 0.0195, respectively). The female group showed positive and significant correlation between claims for self-assessing one's voice (pVHI) and overall GRBAS scores, and between pVHI and grade, roughness, asthenia, and strain components. No significant correlation was found for male patients (p > 0.05). Conclusion A significant number of patients with MS experienced voice problems. The VHI is a good and effective tool to assess patient self-perception of voice quality, but it may not reflect the severity of dysphonia as perceived by voice and speech professionals.

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“…According to the literature, 5,[11][12][13][14] we included the following factors as potential variables associated with improvement of voice intensity (TABLE 1).…”

Section: Methodsmentioning

confidence: 99%

“…M ultiple sclerosis (MS) is a progressive, degenerative neurologic disease leading to demyelination and neurodegeneration involving different parts of the motor system, 1 including control systems for speech and voice. 2,3 Vocal disorders are common problems in people with MS. 2 The predominant voice impairments are harshness, breathiness, phonatory instability, 3 inability to maintain adequate adduction for phonation, 4 vocal fatigue, 5 and higher variability in fundamental frequency and sound pressure level (SPL). Consequently, the voice during conversation is unstable and hypophonic, leading to difficulties at work, participating in conversations with a wide range of people, using the telephone, and communicating in noisy environments.…”

mentioning

confidence: 99%

Factors Associated With Treatment-Related Changes in Voice Volume in People With Multiple Sclerosis

Crispiatico

Baldanzi

Bertuletti

et al. 2022

International Journal of MS Care

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Background: Vocal disorders are frequent in people with multiple sclerosis (MS). Cognitive impairment, fatigue, depression, and other clinical characteristics can be associated with treatment effectiveness in rehabilitation. Finding baseline characteristics that identify those who are responding to treatment can help the clinical decision-making process, which can then help improve the effectiveness of voice treatment. We developed a model to identify factors associated with treatment-related improvement on voice intensity in people with MS. Methods: Data are from a randomized controlled trial of the effects of voice therapy. Forty-four people with MS were enrolled and randomized to receive Lee Silverman Voice Treatment (LSVT) LOUD, specifically addressing voice intensity, or conventional speech-therapy group. Voice intensity (dB) was measured during monologue before and after treatment and was used to differentiate those who responded (posttreatment voice intensity > 60 dB) from those who did not. Possible associated factors were cognitive impairment, fatigue, depression, disability, and disease duration. Associations were assessed by univariate logistic regression and univariate and multivariate linear regressions. Results: Mean ± SD monologue voice intensity in improved in the whole sample (before rehabilitation: 51.8 ± 4.2 dB; and after rehabilitation 57.0 ± 6.5 dB; P < .001), and 11 people with MS (27.5%) responded to treatment. Specificity of treatment was associated with the return to normal voice intensity (OR, 14.28; 95% CI, 12.17-309.56) and we found a linear association between voice improvement and the specificity of treatment (6.65 [SE = 1.54] dB; P < .05). Moreover, the analysis revealed a nonlinear association between improvement and fatigue, suggesting increased benefits for people with MS with moderate fatigue. Other factors were not significantly associated with treatment effectiveness. Conclusions: Moderate fatigue and the specificity of the intervention seem to be key factors associated with clinically relevant improvement in voice intensity even in people with MS with a high level of disability and long disease duration.

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Voice-Related Quality of Life in Patients with Multiple Sclerosis

Cited by 26 publications

References 25 publications

Speech Pathology-Specific Questionnaire for Persons with Multiple Sclerosis (SMS): adaptation, validation and preliminary assessment of the diagnostic potential.

Speech Pathology-Specific Questionnaire for Persons with Multiple Sclerosis (SMS): adaptation, validation and preliminary assessment of the diagnostic potential.

Comparing Voice Self-Assessment with Auditory Perceptual Analysis in Patients with Multiple Sclerosis

Factors Associated With Treatment-Related Changes in Voice Volume in People With Multiple Sclerosis

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