Volatile Anesthetic Modulation of Lung Injury and Outcome in a Murine Model of Multiple Organ Dysfunction Syndrome

Shayevitz,; Jl, Rodriguez Juanotena; Gilligan, Lori J.; Kj, Johnson; Ar, Tait

doi:10.1097/00024382-199507000-00010

Cited by 52 publications

(17 citation statements)

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“…Recently, anti-inflammation properties of sevoflurane have gained attention. Sevoflurane can modulate inflammatory cascades and ischemia/reperfusion (I/R) injury in many organ systems, including the kidney [8,9,10]. Lee [9] recently demonstrated that sevoflurane has protective effects against renal I/R injury in rats and produces antinecrotic and anti-inflammatory effects in in vitro cultures of proximal tubules [10].…”

Section: Sevoflurane Protects Against Acute Kidney Injury In a Small-mentioning

confidence: 99%

Sevoflurane Protects against Acute Kidney Injury in a Small-Size Liver Transplantation Model

et al. 2010

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Background: Living donor liver transplantation (LDLT) patients run the risk of developing acute kidney injury (AKI) and subsequent chronic kidney disease, affecting morbidity and mortality. Sevoflurane has anti-inflammation properties, and renal ischemia/reperfusion under sevoflurane anesthesia resulted in drastic improvements in renal function. Extrahepatic metabolism of sevoflurane has been reported in patients undergoing liver transplantation, and might lead to nephrotoxicity. However, whether sevoflurane anesthesia is safe with regard to renal function in small-size liver transplantation needs further investigation. As neutrophil gelatinase-associated lipocalin (NGAL) is an early predictive biomarker of AKI, we looked at the renal effects of sevoflurane in a rat liver transplantation model using small-for-size grafts to investigate the changes of NGAL level and kidney histology. Methods: Sixty male Sprague-Dawley rats were randomly divided into 2 groups after 50% size liver transplantation. Rats were anesthetized with chloral hydrate or with sevoflurane and subjected to liver transplantation. Twelve rats in each group were used for the survival study and 6 rats were used for the hemodynamic study. Six rats in each group were sacrificed 2 or 24 h after reperfusion. We harvested kidneys and serum for further analysis, including histological and functional parameters; TNF-α, IL-6 and NGAL immunoassay; expressions of myeloperoxidase (MPO) activity; and NF-ĸB in renal tissues. Results: Rats in the sevoflurane group had significantly lower Scr 24 h after reperfusion compared with those in the chloral hydrate group. Rats in the sevoflurane group demonstrated significantly reduced NGAL concentrations compared with rats in the chloral hydrate group 2 h after reperfusion. Epithelial necrosis in the chloral hydrate group (3.2 ± 0.8) was greater than that in the sevoflurane group (1.5 ± 1.1; p < 0.05). Sevoflurane anesthesia resulted in significantly lower plasma TNF-α and IL-6 concentrations and reduced MPO concentrations 2 h after reperfusion (p < 0.05). NF-ĸB protein levels 2 h after reperfusion increased by at least 110% in the chloral hydrate group relative to the sevoflurane group 2 h after reperfusion (p < 0.05). However, the urine inorganic fluoride concentrations increased significantly (p < 0.001) 2 h after reperfusion in the sevoflurane group (6.1 ± 1.5 µmol·l^–1) compared with the chloral hydrate group. Conclusions: Sevoflurane anesthesia can attenuate renal injury and modulate inflammatory cascades in small-size liver transplantation using rat models.

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Section: Sevoflurane Protects Against Acute Kidney Injury In a Small-mentioning

confidence: 99%

Sevoflurane Protects against Acute Kidney Injury in a Small-Size Liver Transplantation Model

et al. 2010

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“…Inhalation anesthetics can induce an inflammatory response in the lung after prolonged exposure (21,22) and may therefore confound the inflammatory response to experimental P. aeruginosa infection in mice using isoflurane anesthesia. Thus, we determined the effect of 5 min of exposure to isoflurane anesthesia on the inflammatory response of CF and wild-type mice.…”

Section: Effect Of Isofluranementioning

confidence: 99%

Response to Acute Lung Infection with Mucoid Pseudomonas aeruginosa in Cystic Fibrosis Mice

Heeckeren

Schluchter

Xue

et al. 2006

Am J Respir Crit Care Med

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“…Modulation of inflammatory cascades and ischemia/reperfusion (I/R) injury by volatile anesthetics has been described in the heart (6, 7), lung (3,8,9), liver (10,11), and kidney (4). We have recently demonstrated that volatile anesthetics protected against renal I/R injury in rats by reducing necrosis and inflammation (4).…”

Section: Introductionmentioning

confidence: 99%

Isoflurane Improves Survival and Protects Against Renal and Hepatic Injury in Murine Septic Peritonitis

Lee

Emala

Joo

et al. 2007

Shock

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We have demonstrated that volatile anesthetics reduce inflammation after renal ischemia/reperfusion injury in vivo. As hyperactive uncontrolled inflammation can lead to mortality and morbidity during early sepsis, we questioned whether the volatile anesthetic isoflurane could reduce mortality and protect against sepsis induced renal and hepatic dysfunction. Mice were anesthetized with isoflurane or with pentobarbital and subjected to cecal ligation and puncture (CLP) to induce septic peritonitis. Mice were anesthetized for an additional 3 h after CLP with either isoflurane or pentobarbital. Renal and hepatic function was assessed 24 h later and survival after CLP was assessed for 7 days. To determine if isoflurane protects by reducing inflammation, we quantified renal tubular expression of pro-inflammatory (intercellular adhesion molecule 1, tumor necrosis factor alpha [TNF-alpha], and interleukin [IL] 1beta) messenger RNA with reverse transcriptase-polymerase chain reaction. We also measured the plasma levels of the pro-inflammatory cytokines TNF-alpha, keratinocyte-derived chemokine (KC), and IL-6 and an anti-inflammatory cytokine IL-10. Renal cortical apoptosis was also assessed 24 h after CLP. Twenty-four hours after the septic insult, isoflurane-treated mice had significantly improved renal and hepatic function compared with mice anesthetized with pentobarbital. Renal cortices of isoflurane-treated mice had significantly reduced expression of intercellular adhesion molecule 1, TNF-alpha, and IL-1beta messenger RNA and showed less apoptosis. Isoflurane-treated mice had lower plasma levels of TNF-alpha, KC, and IL-6. Isoflurane-anesthetized mice also had significantly prolonged and increased survival compared with pentobarbital-anesthetized mice. Therefore, isoflurane anesthesia conferred significant protection against renal and hepatic dysfunction and death after septic peritonitis and attenuated renal inflammation and apoptosis compared with pentobarbital anesthesia.

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Volatile Anesthetic Modulation of Lung Injury and Outcome in a Murine Model of Multiple Organ Dysfunction Syndrome

Cited by 52 publications

References 0 publications

Sevoflurane Protects against Acute Kidney Injury in a Small-Size Liver Transplantation Model

Sevoflurane Protects against Acute Kidney Injury in a Small-Size Liver Transplantation Model

Response to Acute Lung Infection with Mucoid Pseudomonas aeruginosa in Cystic Fibrosis Mice

Isoflurane Improves Survival and Protects Against Renal and Hepatic Injury in Murine Septic Peritonitis

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