2021
DOI: 10.1007/s11064-021-03344-8
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Volatile Anesthetic Sevoflurane Precursor 1,1,1,3,3,3-Hexafluoro-2-Propanol (HFIP) Exerts an Anti-Prion Activity in Prion-Infected Culture Cells

Abstract: Prion disease is a neurodegenerative disorder with progressive neurologic symptoms and accelerated cognitive decline. The causative protein of prion disease is the prion protein (PrP), and structural transition of PrP from the normal helix rich form (PrPC) to the abnormal β-sheet rich form (PrPSc) occurs in prion disease. While so far numerous therapeutic agents for prion diseases have been developed, none of them are still useful. A fluorinated alcohol, hexafluoro isopropanol (HFIP), is a precursor to the inh… Show more

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Cited by 3 publications
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“…Among the polar solvents with good IrO 2 dispersion, the 2-BuOH was selected as a suitable candidate for replacing the conventional IPA-DIW mixture. Other polar solvents have disadvantages for spray coating in large scale: the MeCN is highly volatile and toxic [40] and was also reported to degrade the catalytic activity and proton conductivity in proton exchange membrane [41]; and HFIPA is also toxic [42] and relatively expensive.…”
Section: Dispersion Of the Catalyst In Various Organic Solventsmentioning
confidence: 99%
“…Among the polar solvents with good IrO 2 dispersion, the 2-BuOH was selected as a suitable candidate for replacing the conventional IPA-DIW mixture. Other polar solvents have disadvantages for spray coating in large scale: the MeCN is highly volatile and toxic [40] and was also reported to degrade the catalytic activity and proton conductivity in proton exchange membrane [41]; and HFIPA is also toxic [42] and relatively expensive.…”
Section: Dispersion Of the Catalyst In Various Organic Solventsmentioning
confidence: 99%