Volatile Anesthetics Reduce Biochemical Markers of Brain Injury and Brain Magnesium Disorders in Patients Undergoing Coronary Artery Bypass Graft Surgery

Dąbrowski, Wojciech; Rzecki, Ziemowit; Czajkowski, Marek; Piłat, Jacek; Waciński, Piotr; Kotlinska, Edyta; Sztanke, Małgorzata; Sztanke, Krzysztof; Stazka, Krzysztof; Pasternak, Kazimierz

doi:10.1053/j.jvca.2011.10.014

Cited by 27 publications

(11 citation statements)

References 53 publications

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“…This indicates the need to pay careful attention to the timing of sample collection prior to surgery in future studies on circulating proteins as biomarkers of disease (57–59). …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Eight Plasma Proteins as Candidate Blood-Based Biomarkers for Malignant Gliomas

Lange

Dulloor

Korley

et al. 2014

Cancer Investigation

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Eight brain-derived proteins were evaluated regarding their potential for further development as a blood-based biomarker for malignant gliomas. Plasma levels for glial fibrillary acidic protein, neurogranin, brain-derived neurotrophic factor, intracellular adhesion molecule 5, metallothionein-3, beta-synuclein, S100 and neuron specific enolase were tested in plasma of 23 patients with high-grade gliomas (WHO grade IV), 11 low-grade gliomas (WHO grade II), and 15 healthy subjects. Compared to the healthy controls, none of the proteins appeared to be specific for glioblastomas. However, the data are suggestive of higher protein levels in gliosarcomas (n = 2), which may deserve further exploration.

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“…This indicates the need to pay careful attention to the timing of sample collection prior to surgery in future studies on circulating proteins as biomarkers of disease (57–59). …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Eight Plasma Proteins as Candidate Blood-Based Biomarkers for Malignant Gliomas

Lange

Dulloor

Korley

et al. 2014

Cancer Investigation

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“…KYNA inhibits the same receptors (Bender 1982; Némath et al 2005; Stone et al 2003). Inhalation of SEV or isoflurane reduces perioperative brain injury (Dabrowski et al 2010, 2012). Plasma KYNA concentration correlates with postoperative neuropsychological deficits in cardiac surgery patients (Forrest et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Plasma Kynurenic Acid Concentration in Patients Undergoing Cardiac Surgery: Effect of Anaesthesia

Kotlińska-Hasiec

Nowicka-Stążka

Parada-Turska

et al. 2014

Arch. Immunol. Ther. Exp.

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Increases in plasma kynurenic acid (KYNA) concentration relate to the severity of inflammation. The aim of this study was to analyse changes in plasma KYNA concentration and neutrophil/lymphocyte ratio (NLR) in cardiac surgery patients. Additionally, the effect of anaesthesia was analysed. Adult cardiac surgery patients under intravenous general anaesthesia were studied. Additionally, some patients received sevoflurane (SEV) prior to cardiopulmonary bypass. Plasma KYNA concentration and NLR were measured before anaesthesia, just after surgery and on postoperative days 1, 2 and 3. Patients were assigned to two groups: patients who did not receive SEV (NonSEV group) and patients who received SEV (SEV group). Forty-three patients were studied. Twenty-four of them received SEV. KYNA increased immediately after surgery and remained elevated through postoperative day 3 in the NonSEV group, whereas it was similar to the preoperative concentration in the SEV group. NLR increased immediately after surgery in both groups, and higher values were noted in the NonSEV group than in the SEV group at postoperative days 2 and 3. Plasma KYNA concentration correlated with NLR in the NonSEV group. Cardiac surgery caused an increase in NLR. Plasma KYNA increased in the NonSEV group and correlated with NLR. Administration of SEV inhibited the increase in KYNA, most likely due to its anti-inflammatory properties.

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“…MgSO 4 treatment confers neuroprotection by restoration of blood brain permeability in hypoxia-ischemia (22). Volatile anesthetics, in particular isoflurane and sevoflurane, significantly reduced disturbances in Mg + concentrations in the brain circulation (23). Sevoflurane was likely associated with the worst cognitive outcome as assessed by neuropsychologic tests, as prolonged brain injury was seen with desflurane (24).…”

Section: Discussionmentioning

confidence: 98%

Biomarkers of cerebral injury in cardiac surgery

Yuan¹

2014

Anadolu Kardiyol Derg

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The present study aims to reveal the changing patterns of cerebral biomarkers and the underlying predictive factors as a consequence of cardiac surgery. Literature retrieval of articles on S100 and S100B of recent 20 years were made in the MEDLINE database, Highwire Press and Google search. Quantitative data of S100 and S100B along with neuron-specific enolase were carefully screened, collected and statistically analyzed. The biomarkers appeared earlier and lasted longer in the cerebrospinal fluid than in the serum. All three biomarkers exhibited a similar kinetic trend in the bloodstream, reaching a peak value at the end of cardiopulmonary bypass (CPB). In adults, serum biomarkers may recover to normal earlier than in pediatrics undergoing a cardiac surgery. The patients undergoing off-pump surgery had the minimal elevations of cerebral biomarkers comparing to all other cardiac surgeries under CPB, low core temperature and/or hypothermic circulatory arrest. In patients with pre-or postoperative neurological disorders, the biomarkers in the serum elevated even before operation and persisted longer time than those without neurological disorders. The serum concentrations of the biomarkers showed direct correlation with CPB duration and core temperature. Cardiac operations may lead to cerebral damage and blood-brain barrier changes, as a consequence of CPB and low core temperature. The cerebral biomarkers including S100, S100B and neuron-specific enolase may precisely reflect the cerebral damages in cardiac surgery. Attention has to be paid to the attenuations of cerebral damage by modifying the surgical conditions of CPB and core temperature.

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Volatile Anesthetics Reduce Biochemical Markers of Brain Injury and Brain Magnesium Disorders in Patients Undergoing Coronary Artery Bypass Graft Surgery

Cited by 27 publications

References 53 publications

Evaluation of Eight Plasma Proteins as Candidate Blood-Based Biomarkers for Malignant Gliomas

Evaluation of Eight Plasma Proteins as Candidate Blood-Based Biomarkers for Malignant Gliomas

Plasma Kynurenic Acid Concentration in Patients Undergoing Cardiac Surgery: Effect of Anaesthesia

Biomarkers of cerebral injury in cardiac surgery

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