Volatile Inhibitors of Phosphatidylinositol-3-Kinase (PI3K) Pathway: Anticancer Potential of Aroma Compounds of Plant Essential Oils

Bordoloi, Manobjyoti; Saikia, Surovi; Kolita, Bhaskor; Sarmah, Ranjan Kumar; Roy, Sonali; Narzary, Bardwi

doi:10.2174/1871520617666170327105706

Cited by 16 publications

(7 citation statements)

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“…GC‐MS study of the oils showed the presence of δ‐cadinene, β‐caryophyllen, δ‐elemen, δ‐carene, α and β‐pinene and δ‐3‐carene predominantly. These constituents have been reported to possess anticancer activities (Bordoloi et al, ; Dahham et al, ; Guan et al, ; Hui et al, ; Montanari et al, ; Ramos et al, ; Wang et al, ). The cytotoxic activity of the present study may be due to those components present in the oils.…”

Section: Resultsmentioning

confidence: 99%

Chemical, pharmacological and nutritional quality assessment of black pepper (Piper nigrumL.) seed cultivars

et al. 2018

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The present research has been performed on black pepper of two cultivars to evaluate their nutritional quality and safety issue on the basis of proximate, chemical and pharmacological properties. The proximate results were compiled with the standard USDA limits. K, Ca, Mg, Na, Fe, Al and Se were detected as major elements, whereas the toxic elements were found within the recommended limit. The GC‐MS analysis of the essential oils showed the presence of δ‐3‐carene (32.61%) as the major component in Kerala cultivar whereas β‐caryophyllene (18.39%) was the major components in Indigenous cultivar. The IC50 values of DPPH antioxidant activity of the essential oils were found to be 44.16 and 22.88 mg/mL in Indigenous and Kerala cultivars, respectively. The antimicrobial activity of the essential oils showed good activity in both cultivars. The LC50 values of the brine shrimp cytotoxic activity were 1.03 and 1.21 μg/mL in Indigenous and Kerala cultivars, respectively. Practical applications Spice quality is an important issue in the food industries as well as export markets. Due to the toxicological effect of imported spices, much attention has been paid to the safety issue especially on cytotoxicity and toxic metal contaminations. The present study reveals that both cultivars possess rich amount of nutritional components, essential minerals, phyto and flavouring components in their essential oils and recommended level of toxic elements as well as decent antioxidant and antimicrobial properties. This study promises to scaffold a new window for exportation of quality spice and confer potential for use in food, nutraceutical and pharmaceutical industries.

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Section: Resultsmentioning

confidence: 99%

Chemical, pharmacological and nutritional quality assessment of black pepper (Piper nigrumL.) seed cultivars

et al. 2018

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“…Plant volatiles transmit signaling within and between plants [28]. Some papers showed that volatile compounds from leaves and fruits have a novel source of anticancer drugs [29][30][31]. We wanted to find plant VOCs killing breast cancer stem cells and start screening the VOCs against breast CSC formation using 15 plant VOCs.…”

Section: Discussionmentioning

confidence: 99%

Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal

Choi

Kim

et al. 2020

Antioxidants

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Cancer stem cells (CSCs) are undifferentiated cells that give rise to tumor and resistance to chemotherapy. This study reports that phenylacetaldehyde (PAA), a flower flavor, inhibits formation on breast CSCs. PAA showed anti-proliferation and increased apoptosis of breast cancer. PAA also reduced tumor growth in an in vivo mice model. PAA reduced the CD44+/CD24− and ALDH1-expressing cells, mammosphere formation, and CSC marker genes. PAA preferentially induced reactive oxygen species (ROS) production and combined treatment with PAA and N-acetyl cysteine (NAC) decreased inhibition of mammosphere formation. PAA reduced phosphorylation of nuclear Stat3. PAA inhibited Stat3 signaling through de-phosphorylation of Stat3 and reduced secretory IL-6. Our results suggest that the PAA-induced ROS deregulated Stat3/IL-6 pathway and PAA may be a potential agent targeting breast cancer and CSCs.

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“…Another compound observed to inhibit the growth of cancer cells is cedrol (IC 50 = 44.36 ± 0.9 μg/ml toward C32 human amelanotic melanoma cells; 41.06 ± 0.7 μg/ml toward ACHN human renal cell adenocarcinoma cells), which was shown to increase intracellular ROS production and induce autophagy and apoptotic cell death through the PI3K/Akt signaling pathway in A549 non-small cell lung carcinoma cells [35,36]. Furthermore, thujopsene, a common component in plant extracts, notably inhibited the proliferation of A549 cells (IC50 = 35.27 μg/ml) by decreasing AKT/mTOR protein expression [37]. Many plant extracts or oils, such as Salvia officinalis L. and Xylopia laevigata, contain γ-muurolene and have reported anti-cancer activities [38].…”

Section: Discussionmentioning

confidence: 99%

Cedrus atlantica Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: In Vitro and In Vivo Studies

Chang

Huang

et al. 2021

Int. J. Med. Sci.

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Volatile Inhibitors of Phosphatidylinositol-3-Kinase (PI3K) Pathway: Anticancer Potential of Aroma Compounds of Plant Essential Oils

Abstract: Methyl nonanoate, (R)-citronellol, cis-carveol (L-carveol), 3-methyl-Cyclohexanone, 4-carene and thujopsene were finally screened for PI3K targeted anti-cancer therapies which may find direct application as inhalers or sprays against lung cancer as these compounds are highly volatile.

Cited by 16 publications

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Chemical, pharmacological and nutritional quality assessment of black pepper (Piper nigrumL.) seed cultivars

Chemical, pharmacological and nutritional quality assessment of black pepper (Piper nigrumL.) seed cultivars

Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal

Cedrus atlantica Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: In Vitro and In Vivo Studies

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