Volatile Metabolites in Liverworts of Ecuador

Valarezo, Eduardo; Tandazo, Oswaldo Rafael Tandazo; Galán, Kathia; Rosales, Jandry; Benítez, Ángel

doi:10.3390/metabo10030092

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…Key compounds with the highest proportion included bicyclogermacrene (8.42%), viridiflorene (6.51%), and cis-thujopsene (7.00%), all belonging to the category of hydrocarbon sesquiterpenes. These findings align with our data, underscoring the richness of these compounds in S. rubricaulis and providing valuable confirmation [9]. In the case of S. anomala, analysis using DB5-MS revealed the presence of compounds such as silphiperfola-5,7(14)-diene (25.22%), cis-thujopsene (7.00%), viridiflorene (6.51%), β-vetispirene (8.01%), bicyclogermacrene (8.42%), caryophyllene oxide (8.98%), and β-Oplopenone (6.40%).…”

Section: Discussionsupporting

confidence: 91%

“…In the study of another species, Syzygiella anomala, it was demonstrated that sesquiterpenes constituted the predominant group of compounds. Notable among these were silphiperfola-5,7(14)-diene (25.22%), caryophyllene oxide (8.98%), bicyclogermacrene (8.42%), and β-vetispirene (8.01%) [9].…”

Section: Discussionmentioning

confidence: 99%

“…For instance, they have demonstrated notable antifungal properties [7], along with antibacterial and antiviral effects [8]. Furthermore, both mosses and liverworts showcase anti-inflammatory and antioxidant potential, and they have displayed promising anticancer activity in various cancer cell lines [9]. Leveraging these properties, bryophytes have been traditionally employed in India for treating wounds, cuts, burns, and skin diseases [10].…”

Section: Introductionmentioning

confidence: 99%

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Novel Study on Chemical Characterization and Antimicrobial, Antioxidant, and Anticholinesterase Activity of Essential Oil from Ecuadorian Bryophyte Syzygiella rubricaulis (Nees) Stephani

Morocho,

Benitez,

Carrión

et al. 2024

Plants

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Our research focuses on exploring the chemical composition and some biological properties of the essential oil derived from Syzygiella rubricaulis (Nees) Stephani, a bryophyte species. To conduct a comprehensive analysis, we utilized a DB5MS capillary column along with gas chromatography coupled to mass spectrometry (GC-MS) and flame ionization (GC-FID). The qualitative and quantitative examination revealed the presence of 50 compounds, with hydrocarbon sesquiterpenes (48.35%) and oxygenated sesquiterpenes (46.89%) being the predominant constituents. Noteworthy compounds identified include bicyclogermacrene (12.004%), cedranone <5-> (9.034%), spathulenol (6.835%), viridiflorol (6.334%), silphiperfol-5,7(14)-diene (6.216%), biotol <β-> (6.075%), guaiol (4.607%), viridiflorene (4.65%), and α-guaienol (3.883%). Furthermore, we assessed the antimicrobial, antioxidant, and anticholinesterase activity of the essential oil, revealing a compelling inhibitory effect against acetylcholinesterase (AChE) with an IC50 value of 26.75 ± 1.03 µg/mL and a moderate antimicrobial (MIC 500 µg/mL, Enterococcus faecium, Lysteria monocytogenes) and antioxidant effect (ABTS: SC50 343.38 and DPPH 2650.23 µg/mL). These findings suggest the potential therapeutic application of the bryophyte essential oil in the treatment of Alzheimer’s disease due to its potent anticholinesterase properties.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel Study on Chemical Characterization and Antimicrobial, Antioxidant, and Anticholinesterase Activity of Essential Oil from Ecuadorian Bryophyte Syzygiella rubricaulis (Nees) Stephani

Morocho,

Benitez,

Carrión

et al. 2024

Plants

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“…For example, in the liverwort Frullania brasiliensis Raddi and moss Campylopus richardii Brid. oils, the stereoisomer epi -α-muurolol was the primary constituent, with 32.18 % and 15.1 %, respectively [ 9 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

Volatile concentrate from the neotropical moss Neckeropsis undulata (Hedw.) Reichardt, existing in the brazilian Amazon

et al. 2021

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Background Many natural compounds have been identified and synthesized by the advancement of bryophytes phytochemistry studies. This work aimed to report the composition of Neckeropsis undulata (Hedw.) Reichardt moss volatiles, sampled in the Combú Island, Belém city, Pará state, Brazil. The volatile concentrate of N. undulata was obtained by a simultaneous distillation-extraction micro-system, analyzed by GC and GC-MS, and reported for the first time. Results Ten compounds were identified in the volatile concentrate, corresponding to 91.6% of the total, being 1-octen-3-ol (35.7%), α-muurolol (21.4%), naphthalene (11.3%), and n-hexanal (10.0 %) the main constituents. Most of the constituents of the N. undulata volatile concentrate have been previously identified in other mosses, and liverworts spread wide in the world. Conclusions 1-Octen-3-ol, n-hexanal, 2-ethylhexanol, isoamyl propionate, and octan-3-one are already known metabolic products obtained from enzymatic oxidation of polyunsaturated fatty acids, belonging to the large family of minor oxygenated compounds known as oxylipins. The knowledge of the composition of volatiles from moss N. undulata could contribute to the Neckeraceae species’ chemotaxonomy.

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“…Some of the aromas are specific only to a single species of liverwort. Valarenzo et al [37] screened volatile metabolites in four liverwort species. Depending on the species studied, it was not possible to identify 10 to 15% of the essential oil compounds, and they require further research.…”

Section: Volatile Compoundsmentioning

confidence: 99%

Modern Use of Bryophytes as a Source of Secondary Metabolites

et al. 2022

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Bryophytes constitute a heterogeneous group of plants which includes three clades: approximately 14,000 species of mosses (Bryophyta), 6000 species of liverworts (Marchantiophyta), and 300 species of hornworts (Anthocerotophyta). They are common in almost all ecosystems, where they play important roles. Bryophytes lack developed physical barriers, yet they are rarely attacked by herbivores or pathogens. Instead, they have acquired the ability to produce a wide range of secondary metabolites with diverse functions, such as phytotoxic, antibacterial, antifungal, insect antifeedant, and molluscicidal activities. Secondary metabolites in bryophytes can also be involved in stress tolerance, i.e., in UV-absorptive and drought- and freezing-tolerant activities. Due to these properties, for centuries bryophytes have been used to combat health problems in many cultures on different continents. Currently, scientists are discovering new, unique compounds in bryophytes with potential for practical use, which, in the age of drug resistance, may be of considerable importance. The aim of this review is to present bryophytes as a potential source of compounds with miscellaneous possible uses, with a focus on volatile compounds and antibacterial, antifungal, and cytotoxic potential, and as sources of materials for further promising research. The paper also briefly refers to the methods of compound extraction and acquisition. Formulas of compounds were drawn by the authors using ChemDraw software (PerkinElmer, Boston, MA, USA) with reference to data published in various papers, the ACD/Labs dictionary database, PubChem, and Scopus. The data were gathered in February 2022.

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Volatile Metabolites in Liverworts of Ecuador

Cited by 6 publications

References 19 publications

Novel Study on Chemical Characterization and Antimicrobial, Antioxidant, and Anticholinesterase Activity of Essential Oil from Ecuadorian Bryophyte Syzygiella rubricaulis (Nees) Stephani

Novel Study on Chemical Characterization and Antimicrobial, Antioxidant, and Anticholinesterase Activity of Essential Oil from Ecuadorian Bryophyte Syzygiella rubricaulis (Nees) Stephani

Volatile concentrate from the neotropical moss Neckeropsis undulata (Hedw.) Reichardt, existing in the brazilian Amazon

Modern Use of Bryophytes as a Source of Secondary Metabolites

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