Volatile organic compounds: Potential biomarkers for improved diagnosis and monitoring of diabetic wounds

Daneshkhah, Ali; Siegel, Amanda P.; Agarwal, Mangilal

doi:10.1016/b978-0-12-816413-6.00023-x

Cited by 10 publications

(14 citation statements)

References 123 publications

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“…Population urbanization and awareness regarding health in people having either a stressed or sedentary lifestyle are the major reasons promoting the growth of the market for fish nutraceuticals all over the world (17). It has been recently reported that fish nutraceuticals can provide some positive strategies for managing human health exerting significant beneficial impacts on healthcare (18). A broad variety of phytochemicals like glucosinolates, terpenoids, limonoids, phytosterols, polyphenols, anthocyanidin, carotenoids, phytoestrogens, flavonoids, and isoflavonoids have imposed several therapeutic actions on human health including antioxidant, anti-inflammatory, anti-allergic, and antibacterial impacts (19).…”

Section: Fish Nutraceuticalsmentioning

confidence: 99%

Seafood Discards: A Potent Source of Enzymes and Biomacromolecules With Nutritional and Nutraceutical Significance

Nag

Lahiri

Dey³

et al. 2022

Front. Nutr.

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In recent times, the seafood industry is found to produce large volumes of waste products comprising shrimp shells, fish bones, fins, skins, intestines, and carcasses, along with the voluminous quantity of wastewater effluents. These seafood industry effluents contain large quantities of lipids, amino acids, proteins, polyunsaturated fatty acids, minerals, and carotenoids mixed with the garbage. This debris not only causes a huge wastage of various nutrients but also roots in severe environmental contamination. Hence, the problem of such seafood industry run-offs needs to be immediately managed with a commercial outlook. Microbiological treatment may lead to the valorization of seafood wastes, the trove of several useful compounds into value-added materials like enzymes, such as lipase, protease, chitinase, hyaluronidase, phosphatase, etc., and organic compounds like bioactive peptides, collagen, gelatin, chitosan, and mineral-based nutraceuticals. Such bioconversion in combination with a bio-refinery strategy possesses the potential for environment-friendly and inexpensive management of discards generated from seafood, which can sustainably maintain the production of seafood. The compounds that are being produced may act as nutritional sources or as nutraceuticals, foods with medicinal value. Determining utilization of seafood discard not only reduces the obnoxious deposition of waste but adds economy in the production of food with nutritional and medicinal importance, and, thereby meets up the long-lasting global demand of making nutrients and nutraceuticals available at a nominal cost.

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Section: Fish Nutraceuticalsmentioning

confidence: 99%

Seafood Discards: A Potent Source of Enzymes and Biomacromolecules With Nutritional and Nutraceutical Significance

Nag

Lahiri

Dey³

et al. 2022

Front. Nutr.

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“…There are immeasurable resources waiting to be discovered in the form of AI-nanoconjugate synergy. Volatile organic compounds (VOCs) are potential biomarkers for the diagnosis and surveillance of diabetic wounds [ 285 ]. Researchers have devised an ultra-selective detection of volatile organic compounds (VOCs) via an AI-nanomaterial sensor system.…”

Section: Advanced Nanotechnologymentioning

confidence: 99%

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

et al. 2022

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The healing of chronic wound infections, especially cutaneous wounds, involves a complex cascade of events demanding mutual interaction between immunity and other natural host processes. Wound infections are caused by the consortia of microbial species that keep on proliferating and produce various types of virulence factors that cause the development of chronic infections. The mono- or polymicrobial nature of surface wound infections is best characterized by its ability to form biofilm that renders antimicrobial resistance to commonly administered drugs due to poor biofilm matrix permeability. With an increasing incidence of chronic wound biofilm infections, there is an urgent need for non-conventional antimicrobial approaches, such as developing nanomaterials that have intrinsic antimicrobial-antibiofilm properties modulating the biochemical or biophysical parameters in the wound microenvironment in order to cause disruption and removal of biofilms, such as designing nanomaterials as efficient drug-delivery vehicles carrying antibiotics, bioactive compounds, growth factor antioxidants or stem cells reaching the infection sites and having a distinct mechanism of action in comparison to antibiotics—functionalized nanoparticles (NPs) for better incursion through the biofilm matrix. NPs are thought to act by modulating the microbial colonization and biofilm formation in wounds due to their differential particle size, shape, surface charge and composition through alterations in bacterial cell membrane composition, as well as their conductivity, loss of respiratory activity, generation of reactive oxygen species (ROS), nitrosation of cysteines of proteins, lipid peroxidation, DNA unwinding and modulation of metabolic pathways. For the treatment of chronic wounds, extensive research is ongoing to explore a variety of nanoplatforms, including metallic and nonmetallic NPs, nanofibers and self-accumulating nanocarriers. As the use of the magnetic nanoparticle (MNP)-entrenched pre-designed hydrogel sheet (MPS) is found to enhance wound healing, the bio-nanocomposites consisting of bacterial cellulose and magnetic nanoparticles (magnetite) are now successfully used for the healing of chronic wounds. With the objective of precise targeting, some kinds of “intelligent” nanoparticles are constructed to react according to the required environment, which are later incorporated in the dressings, so that the wound can be treated with nano-impregnated dressing material in situ. For the effective healing of skin wounds, high-expressing, transiently modified stem cells, controlled by nano 3D architectures, have been developed to encourage angiogenesis and tissue regeneration. In order to overcome the challenge of time and dose constraints during drug administration, the approach of combinatorial nano therapy is adopted, whereby AI will help to exploit the full potential of nanomedicine to treat chronic wounds.

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“…For instance, in the case of wound formation and healing, colonization of different bacterial and fungal species on the wound surface prompts the release of different VOCs, as depicted in Figure 7a. These VOC biomarkers have a long list [78,79], among which some commonly observed compounds are organic acids (n-hexanoic, 2-methylhexanoic, n-octanoic, n-decanoic, n-undecanoic), carbonyls (γ-C8-lactone, γ-C9-lactone, γ-C10-lactone), and alcohol (phenol, tetradecanol, n-hexadecanol) [80]. The concentration profiles of these VOCs are very different from one another and are not uniform in each patient.…”

Section: Voc Biomarkers In a Chronic Woundmentioning

confidence: 99%

Emerging Strategies Based on Sensors for Chronic Wound Monitoring and Management

et al. 2022

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Pressure ulcers (PUs) are a serious global health challenge, affecting a large section of the population and putting immense pressure on healthcare systems. Sensor-based diagnostic tools and monitoring systems have emerged as a potential non-invasive solution to reduce the occurrence of new cases of PUs and promise a significant reduction in treatment expenditure and time. In this endeavour, the present manuscript reviews the advancements made in the last decade in the development and commercial adoption of different sensor systems for PU-associated chronic wound management. Different types of smart sensor systems have been developed in which pressure, chemical, and optical sensors have witnessed a lot of interest and significant advancement among research communities and industries alike. These sensors utilize a host of nanomaterial-based sensing materials, flexible support, diverse transducing modes, and different device designs to achieve high sensitivity and selectivity for skin pressure, temperature, humidity, and biomarkers released from the wound. Some of these sensor’s array-based electronic skin (e-skin) has reached the stage of commercialization and is being used in commercial products, such as smart bandages, shoes, watches, and mattress among others. Nonetheless, further innovations are necessary in the direction of associating multiple types of sensor arrays, particularly pressure and chemical sensor-based e-skins in a microsystem for performing real-time assessment of all the critical wound parameters.

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Volatile organic compounds: Potential biomarkers for improved diagnosis and monitoring of diabetic wounds

Cited by 10 publications

References 123 publications

Seafood Discards: A Potent Source of Enzymes and Biomacromolecules With Nutritional and Nutraceutical Significance

Seafood Discards: A Potent Source of Enzymes and Biomacromolecules With Nutritional and Nutraceutical Significance

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

Emerging Strategies Based on Sensors for Chronic Wound Monitoring and Management

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