Volatile organic solvent-induced signal enhancements in inductively coupled plasma-mass spectrometry: a case study of methanol and acetone

Hu, Zhaochu; Hu, Shenghong; Gao, Shan; Liu, Yongsheng; Lin, Soulin

doi:10.1016/j.sab.2004.07.007

Cited by 141 publications

(119 citation statements)

References 18 publications

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“…Hence, the smaller droplets formed in the nebulizer aerosol may improve the analyte drop transport efficiency. Otherwise, at higher methanol concentration, the temperature of plasma decreases and this cooling can result in a diminution of the ionization efficiency [4,27]. As expected, a noticeable decrease of the intensity at m/z 48 was observed with increasing flow rates of the mobile phase.…”

Section: Optimization Of the Icp/ms Conditions For Sulfur Detectionsupporting

confidence: 71%

Determination of S-containing drug metabolites from in vitro and in vivo metabolism studies by using LC-ICP/MS

et al. 2012

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Recently, liquid chromatography coupled to inductively coupled plasma mass spectrometry (LC-ICP/MS) has been introduced to deal with some applications in the field of pharmaceutical, biomedical, and clinical analysis. In the case of drug research, the number of drugs and their metabolites containing detectable elements is quite limited. In this paper, LC-ICP/MS has been demonstrated to be suitable for the determination of S-containing drugs and their metabolites. In order to minimize the interference of polyatomic oxygen (m/z 32), the indirect detection of S, by means of the SO(+) ion (m/z 48), was optimized. For quantification purposes, it has been encountered that the percentage of organic solvent in the mobile phase strongly affects the sensitivity. Here, corrective strategies based on calibration curves established at different solvent concentrations (solvent-zone quantification) and post-column gradient compensation have been proposed to circumvent sensitivity variations. Results obtained have shown that suitable calibration models have been built for any compound regardless of the solvent percentage at which it is eluted from the chromatographic column. To prove the applicability of this methodology, the metabolism of ethacrynic acid and tiotropium bromide has been studied in vitro and in vivo. In the first case, ethacrynic acid does not contain S in its structure, however, the major route of metabolism for this compound consists of the formation of glutathione adduct and its further degradation. In the second case, tiotropium bromide contains two S atoms in its structure.

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Section: Optimization Of the Icp/ms Conditions For Sulfur Detectionsupporting

confidence: 71%

Determination of S-containing drug metabolites from in vitro and in vivo metabolism studies by using LC-ICP/MS

et al. 2012

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“…The net signal gain caused by the introduction of a carbon source into the plasma is caused by the increased ionization of elements of high ionization potential, such as Se (9.75 eV), and this enhancement signal is promoted by charge transfer reactions that occur between positively charged carbon species and Se atoms in the central channel of the plasma. [24][25][26] The Se signal gains varied according to the use or not of CRI with an H 2 introduction through the skimmer cone (Figures 1a, 1b and 1c) . Due to the noticeable decrease of the net signals when introducing 80 mL min -1 H 2 through the skimmer cone, this flow rate was not used in further experiments.…”

Section: Resultsmentioning

confidence: 99%

Determination of Selenium in Bovine Semen by ICP-MS Using Formic Acid for Sample Preparation

Bianchi

Amaral

Silva

et al. 2017

J. Braz. Chem. Soc.

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Determination of Se by inductively coupled plasma mass spectrometry (ICP-MS) can be difficult due to spectral interferences; however, these interferences can be eliminated by using collision-reaction interface (CRI) technology. A simple and fast procedure for determination of total Se concentration in bovine semen by ICP-MS after sample solubilization with diluted formic acid is here proposed. Formic acid caused an increase of up to 50% in selenium net signals and the maximum gain was obtained at 10% v v -1 formic acid solution. The optimized nebulizer gas flow rates were 1.05 and 0.95 L min -1 , and radio frequency applied power were 1.3 and 1.4 kW without and with CRI, respectively. Microwave-assisted acid digestion was also implemented in the preparation of semen sample for comparison of results. No statistical differences between these sample preparation strategies at 95% confidence level (t-test) were observed for

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“…In spite of that, little amounts of organic compounds can raise the nebulization and aerosol transport efficiencies in the plasma, improving the ionization efficiency of high ionization energy elements by carbon charge transfer reactions (Boorn & Browner, 1982;Hu, Hu, Gao, Liu, & Lin, 2004;dos Santos et al, 2007;Tormen, Chaves, Saint'Pierre, Frescura, & Curtius, 2008). For that reason is mandatory an overall instrument performance optimization, considering mainly sample matrix.…”

Section: Instrument Optimizationmentioning

confidence: 99%

Classification of monovarietal Argentinean white wines by their elemental profile

et al. 2015

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Volatile organic solvent-induced signal enhancements in inductively coupled plasma-mass spectrometry: a case study of methanol and acetone

Cited by 141 publications

References 18 publications

Determination of S-containing drug metabolites from in vitro and in vivo metabolism studies by using LC-ICP/MS

Determination of S-containing drug metabolites from in vitro and in vivo metabolism studies by using LC-ICP/MS

Determination of Selenium in Bovine Semen by ICP-MS Using Formic Acid for Sample Preparation

Classification of monovarietal Argentinean white wines by their elemental profile

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