Volatile profiling coupled with multivariate analysis, antiproliferative and anti-inflammatory activities of rhizome essential oil of four Hedychium species from India

Mohanty, Swagat; Ray, Asit; Sahoo, Chiranjibi; Sahoo, Ambika; Jena, Sudipta; Panda, Pratap Chandra; Nayak, Sanghamitra

doi:10.1016/j.jep.2023.116835

Cited by 7 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, an H. spicatum EO decreased Bcl-2 and Bcl-xL and increased Bax and Bak protein levels [66]. Other species, Hedychium genus, H. coccineum, H. gardnerianum, H. greenii and H. griffithianum, also showed antiproliferative activity against PC3 cells [67].…”

Section: Other Speciesmentioning

confidence: 98%

Therapeutic Effects of Essential Oils and Their Bioactive Compounds on Prostate Cancer Treatment

Pimentel,

Bastos,

Goulart

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Since prostate cancer (PCa) relies on limited therapies, more effective alternatives are required. Essential oils (EOs) and their bioactive compounds are natural products that have many properties including anticancer activity. This review covers studies published between 2000 and 2023 and discusses the anti-prostate cancer mechanisms of the EOs from several plant species and their main bioactive compounds. It also provides a critical perspective regarding the challenges to be overcome until they reach the market. EOs from chamomile, cinnamon, Citrus species, turmeric, Cymbopogon species, ginger, lavender, Mentha species, rosemary, Salvia species, thyme and other species have been tested in different PCa cell lines and have shown excellent results, including the inhibition of cell growth and migration, the induction of apoptosis, modulation in the expression of apoptotic and anti-apoptotic genes and the suppression of angiogenesis. The most challenging aspects of EOs, which limit their clinical uses, are their highly lipophilic nature, physicochemical instability, photosensitivity, high volatility and composition variability. The processing of EO-based products in the pharmaceutical field may be an interesting alternative to circumvent EOs' limitations, resulting in several benefits in their further clinical use. Identifying their bioactive compounds, therapeutic effects and chemical structures could open new perspectives for innovative developments in the field. Moreover, this could be helpful in obtaining versatile chemical synthesis routes and/or biotechnological drug production strategies, providing an accurate, safe and sustainable source of these bioactive compounds, while looking at their use as gold-standard therapy in the close future.

show abstract

Section: Other Speciesmentioning

confidence: 98%

Therapeutic Effects of Essential Oils and Their Bioactive Compounds on Prostate Cancer Treatment

Pimentel,

Bastos,

Goulart

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

From 2015 to 2023: How Machine Learning Aids Natural Product Analysis

Shi,

Huang,

et al. 2024

Chemistry Africa

View full text Add to dashboard Cite

In recent years, conventional chemistry techniques have faced significant challenges due to their inherent limitations, struggling to cope with the increasing complexity of and volume of data generated in contemporary research endeavors. Computational methodologies represent robust tools in the field of chemistry, offering the capacity to harness potent machine learning (ML) models to yield insightful analytical outcomes. This review examines the integration of machine learning into natural product chemistry from 2015 to 2023, highlighting its potential to overcome the inherent limitations of traditional chemical techniques. We present a structured approach that matches specific natural product challenges—such as component determination, concentration prediction, and classification—with suitable ML models, including regression, classification, and dimension reduction methods. Our objective is to illustrate how ML pipelines, from data preprocessing to model evaluation, enhance both qualitative and quantitative analyses, providing a comprehensive framework, with the potential catalyze a transformation in the field of natural product analysis.

show abstract

Bioevaluation, pharmacokinetics and molecular docking study of terpenoid-rich rhizome essential oil of Zingiber officinale

Nayak,

Gadnayak,

Sahoo

et al. 2024

Gene Reports

View full text Add to dashboard Cite

Volatile profiling coupled with multivariate analysis, antiproliferative and anti-inflammatory activities of rhizome essential oil of four Hedychium species from India

Cited by 7 publications

References 44 publications

Therapeutic Effects of Essential Oils and Their Bioactive Compounds on Prostate Cancer Treatment

Therapeutic Effects of Essential Oils and Their Bioactive Compounds on Prostate Cancer Treatment

From 2015 to 2023: How Machine Learning Aids Natural Product Analysis

Bioevaluation, pharmacokinetics and molecular docking study of terpenoid-rich rhizome essential oil of Zingiber officinale

Contact Info

Product

Resources

About