Volksmusik südosteuropas

Anti-inflammatory actions of dapsone and its related biochemistry

“…The biochemical results showed that dapsone shares with many other anti-inflammatory drugs the property of stabilizing lysosomes and polymorphs although the different results obtained for the rat lysosomes when compared to those of the guinea-pig illustrates the caution advocated by Ignarro (1971) in that the properties of a lysosomal preparation depend largely on its source and mode of preparation. The stabilizing action of dapsone on the polymorphonuclear leucocytes may be relevant since these cells accummulate at the site of inflammation (Hersh & Bodey, 1970) and may be responsible for the release of lysosomal enzymes such as proteases (Weissmann, 1969) which have been reported to cause tissue destruction in joint disease (Dingle, 1962). We have also found that dapsone stabilized a protein, which is a property of many other anti-inflammatory drugs (Mizushima, 1964), but whether this property is responsible for the stabilizing action of the drug on membranes it is not yet possible to say.…”